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The map label for this gene is proA

Identifier: 218904104

GI number: 218904104

Start: 2824584

End: 2825831

Strand: Reverse

Name: proA

Synonym: BCAH820_2988

Alternate gene names: 218904104

Gene position: 2825831-2824584 (Counterclockwise)

Preceding gene: 218904105

Following gene: 218904101

Centisome position: 53.29

GC content: 39.1

Gene sequence:

>1248_bases
ATGAATGAAGTGTTAGCAAAGGGAAAGAAGGCGAAAGAGATCGCTAGAGAGCTAGTGCTTAAATCTACAGAGCAAAAAAA
CGAAGCACTTTCCGCAATAGCTGATCAGTTAATATTAGAAACAGCTTATATTTTAGAAGAAAATAAGAAGGATATTGAAG
AAGGTAAGGCAAAAGGGTTTTCTGATTCTCTCCTTGATCGCCTTATGCTGAATGAACAGCGTATTGTTGATATGACAGAA
GGGATTAAGCAGCTAATTGAATTACGTGATCCTGTAGGAGAATGTGTAAGTGCATGGGAAAGGCCAAATGGACTATCTAT
TCAGGAAATGCGCGTACCACTTGGTGTTGTTGGGATGATTTACGAGGCAAGACCGAATGTAACAGTGGATGCTGCTACAA
TTTGTTTGAAGACAGGAAACGCAGTCATATTACGTGGTAGTTCTTCTGCTATTCATTCTAATAAAGCCATCGTTGCCGTT
ATTCACAGAGCGCTCAAACAAACAAGCTTACCTCAAGAAAGTGTACAGCTTATAGAAGATACAACGCGAGATAGCGCAAA
GCAGTTGTTTACAATGAATGATTATCTAGACGTTCTTATTCCAAGAGGTGGCAAGCAATTAATCGATACTGTTGTGAGGG
AAGCGTCTGTCCCAGTACTTGAAACAGGTGCGGGAAATTGTCATGTTTTCATTGATGAAACAGCGGATAAACAAATGGCA
TTTGATATTATTATAAATGCAAAAACGCAGCGTCCATCTGTATGTAATGCAATTGAAACGATTGTACTTCATGAGAAGTG
GGCAGAGCAATATGGTAGCGAGTTGTTTTCTTCTTTGAAGAAAAGAGGCGTGGAGCTACGTGGTGATCAAAAAGCATTGG
CAATGGATTCATCAATTGTACTTGCTTCAGAAGAAGACTGGGGGACAGAATTTTTATCTCTCACGCTAGCAGTTAAATTA
GTTTCTTCTATAGAAGAAGCGATTCATCACATAAATACGTATGGATCTATGCATTCTGAAGCGATTATTTCAGAAAACGA
GGAAAATGTCAGCAAATTTTTCGTATCTGTTGATGCGGCTGCACTGTATCATAATGCATCAACTCGTTTTACTGATGGAT
CTGAATTCGGATTTGGAGCAGAAATTGGTATCAGTACACAAAAGCTACACGTAAGAGGACCAATGGGGCTTCCTGCATTA
ACTTCTACAAAATACGTCATTCGTGGAAATGGACAAATTCGAAAATAA

Upstream 100 bases:

>100_bases
AACAGATTCAAGCAAGAGGCGAAAGACATAATTATGAAGTCATTCATAGAGATTATTGGGTTTCATTTTAAGAAGATGGA
TCAAAAAGGAGGAAATAAAA

Downstream 100 bases:

>100_bases
AAATAAAAGACACTCAATTCGTTTGGGTGTCTTTTATTTTAAAAATTATTTACCATACAAAAAGCCCAACAAGCATAGCG
CTTAATAAGGAAACAGCCAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYVIRGNGQIRK

Sequences:

>Translated_415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYVIRGNGQIRK
>Mature_415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYVIRGNGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=31.7961165048544, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=31.7961165048544, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=43.7956204379562, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=409, Percent_Identity=34.2298288508557, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17569967, Length=409, Percent_Identity=34.2298288508557, Blast_Score=256, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=37.2365339578454, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=34.0632603406326, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_BACC0 (B7JD15)

Other databases:

- EMBL:   CP001283
- RefSeq:   YP_002451938.1
- ProteinModelPortal:   B7JD15
- SMR:   B7JD15
- EnsemblBacteria:   EBBACT00000087482
- GeneID:   7190841
- GenomeReviews:   CP001283_GR
- KEGG:   bcu:BCAH820_2988
- GeneTree:   EBGT00050000000020
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45598; Mature: 45598

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA