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The map label for this gene is lip2 [H]

Identifier: 218903849

GI number: 218903849

Start: 2595881

End: 2596837

Strand: Direct

Name: lip2 [H]

Synonym: BCAH820_2733

Alternate gene names: 218903849

Gene position: 2595881-2596837 (Clockwise)

Preceding gene: 218903840

Following gene: 218903858

Centisome position: 48.95

GC content: 38.45

Gene sequence:

>957_bases
ATGAAAACTAGAGTAAATCCAGAATTATTACAAGGGTTAGAGATGTTTCCGGATCTCGATTTACGCCCAGAAAATTTGCA
ATCAATCAGAGAAGGAATAGCTCAAATGAGACCACCTACCGTTGTTGATGACTCCCTTTCTTTAATAGATAAAGTCATTG
TTGGGCCTGATGATAATCCGTTACCATTACGAATTTATCGTCCAAAATCAAATCATGAATCTTTACCTGTCTTATTATGG
ATACATGGTGGAGGTTATATCTTAGGGTCTATAGATGATAACGATGATACTTGTATGAGGTTTGCAAAAGAAGCTAGCTG
TGTGGTCGTGTCTGTAGACTACCGCTTAGCACCTGAACACCCTTACCCAGCACCAATTGAGGATTGTTATTCAGCTTTAA
AATGGATTGCTGATAATGCAAAGTCATTAAACATTGATTCGAATCGAATTGGGGTTGCAGGAGTAAGCGCTGGCGGTGGA
CTAACAGCAGCATTATCATTATTAGCACGAGATCGAAAATATCCTTCAATTTGTTTACAAATGCCACTATATCCAATGAT
TGATGACCGAAATAATACACCTTCAGCCAATGAAATTAAAGAAGGATTTGTTTGGAACCAAAGGGCAAATGAAGCTGGCT
GGAAAATGTATTTAGGAGAAATGTATGGAATGGATCAAATCCCTGCATATGCAGCGCCTTCTCGAGCTGAGGATTATAGT
GACTTACCGTATACTTACACATTTGTAGGTCAATTAGATCCATTCCGAAGCGAAACATTAACCTATGTAAGCAAACTAGC
GCAAGCTGGTGTTGATGTCGAGTTTCATTTATATCCAAATGCCTATCACTGGTTTGAAGGGTTAAATCCAAATGCCGATG
TATCTATTTATGCTGTGAACGAAATAGTACAAGCAATAAAAACTGGGTTCAAACGAGTATCTAAGGTTGAGGCTTAA

Upstream 100 bases:

>100_bases
ACATATCCAATTTACAATTTAATTGTGGTGTTCTTTCACAATTAAACTACTTAGAATACACTTCATTTATTTGAAAACAA
TTACAAATAGAGGTGCTAAA

Downstream 100 bases:

>100_bases
TCCCATTACAAGAGAAACACTCATAAATAGTATACATTGGTGAGTGTTATTATCATTTAAATATAATAGCCGATTCTTAT
TTGAAATCGGCTATTATATT

Product: carboxylesterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKTRVNPELLQGLEMFPDLDLRPENLQSIREGIAQMRPPTVVDDSLSLIDKVIVGPDDNPLPLRIYRPKSNHESLPVLLW
IHGGGYILGSIDDNDDTCMRFAKEASCVVVSVDYRLAPEHPYPAPIEDCYSALKWIADNAKSLNIDSNRIGVAGVSAGGG
LTAALSLLARDRKYPSICLQMPLYPMIDDRNNTPSANEIKEGFVWNQRANEAGWKMYLGEMYGMDQIPAYAAPSRAEDYS
DLPYTYTFVGQLDPFRSETLTYVSKLAQAGVDVEFHLYPNAYHWFEGLNPNADVSIYAVNEIVQAIKTGFKRVSKVEA

Sequences:

>Translated_318_residues
MKTRVNPELLQGLEMFPDLDLRPENLQSIREGIAQMRPPTVVDDSLSLIDKVIVGPDDNPLPLRIYRPKSNHESLPVLLW
IHGGGYILGSIDDNDDTCMRFAKEASCVVVSVDYRLAPEHPYPAPIEDCYSALKWIADNAKSLNIDSNRIGVAGVSAGGG
LTAALSLLARDRKYPSICLQMPLYPMIDDRNNTPSANEIKEGFVWNQRANEAGWKMYLGEMYGMDQIPAYAAPSRAEDYS
DLPYTYTFVGQLDPFRSETLTYVSKLAQAGVDVEFHLYPNAYHWFEGLNPNADVSIYAVNEIVQAIKTGFKRVSKVEA
>Mature_318_residues
MKTRVNPELLQGLEMFPDLDLRPENLQSIREGIAQMRPPTVVDDSLSLIDKVIVGPDDNPLPLRIYRPKSNHESLPVLLW
IHGGGYILGSIDDNDDTCMRFAKEASCVVVSVDYRLAPEHPYPAPIEDCYSALKWIADNAKSLNIDSNRIGVAGVSAGGG
LTAALSLLARDRKYPSICLQMPLYPMIDDRNNTPSANEIKEGFVWNQRANEAGWKMYLGEMYGMDQIPAYAAPSRAEDYS
DLPYTYTFVGQLDPFRSETLTYVSKLAQAGVDVEFHLYPNAYHWFEGLNPNADVSIYAVNEIVQAIKTGFKRVSKVEA

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=291, Percent_Identity=28.1786941580756, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI157041239, Length=295, Percent_Identity=26.1016949152542, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI68299767, Length=314, Percent_Identity=26.4331210191083, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI61966717, Length=131, Percent_Identity=30.5343511450382, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI68051721, Length=155, Percent_Identity=31.6129032258064, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21328446, Length=103, Percent_Identity=33.0097087378641, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786682, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540028, Length=132, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17567059, Length=260, Percent_Identity=25.7692307692308, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=133, Percent_Identity=30.8270676691729, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI72001146, Length=149, Percent_Identity=31.5436241610738, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533410, Length=91, Percent_Identity=37.3626373626374, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533412, Length=91, Percent_Identity=37.3626373626374, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656084, Length=105, Percent_Identity=32.3809523809524, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24656076, Length=105, Percent_Identity=32.3809523809524, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20130169, Length=105, Percent_Identity=32.3809523809524, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 35481; Mature: 35481

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRVNPELLQGLEMFPDLDLRPENLQSIREGIAQMRPPTVVDDSLSLIDKVIVGPDDNP
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHEECCCCCC
LPLRIYRPKSNHESLPVLLWIHGGGYILGSIDDNDDTCMRFAKEASCVVVSVDYRLAPEH
CCEEEECCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHCCCEEEEEECCEECCCC
PYPAPIEDCYSALKWIADNAKSLNIDSNRIGVAGVSAGGGLTAALSLLARDRKYPSICLQ
CCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
MPLYPMIDDRNNTPSANEIKEGFVWNQRANEAGWKMYLGEMYGMDQIPAYAAPSRAEDYS
CCCCEEECCCCCCCCHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DLPYTYTFVGQLDPFRSETLTYVSKLAQAGVDVEFHLYPNAYHWFEGLNPNADVSIYAVN
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCCEEEEEHH
EIVQAIKTGFKRVSKVEA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTRVNPELLQGLEMFPDLDLRPENLQSIREGIAQMRPPTVVDDSLSLIDKVIVGPDDNP
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHEECCCCCC
LPLRIYRPKSNHESLPVLLWIHGGGYILGSIDDNDDTCMRFAKEASCVVVSVDYRLAPEH
CCEEEECCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHCCCEEEEEECCEECCCC
PYPAPIEDCYSALKWIADNAKSLNIDSNRIGVAGVSAGGGLTAALSLLARDRKYPSICLQ
CCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
MPLYPMIDDRNNTPSANEIKEGFVWNQRANEAGWKMYLGEMYGMDQIPAYAAPSRAEDYS
CCCCEEECCCCCCCCHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DLPYTYTFVGQLDPFRSETLTYVSKLAQAGVDVEFHLYPNAYHWFEGLNPNADVSIYAVN
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCCEEEEEHH
EIVQAIKTGFKRVSKVEA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]