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The map label for this gene is fes [H]

Identifier: 218903824

GI number: 218903824

Start: 2576617

End: 2578242

Strand: Reverse

Name: fes [H]

Synonym: BCAH820_2708

Alternate gene names: 218903824

Gene position: 2578242-2576617 (Counterclockwise)

Preceding gene: 218903825

Following gene: 218903823

Centisome position: 48.62

GC content: 32.35

Gene sequence:

>1626_bases
GTGACTACAATAATCAGTCCTAAGTTAGAGAAGCTTAAAAATCACTTAAAGAATGGAAATGAAAAAGCTCTTTATACTTT
TTTGCATGAAATCAAGTCAAATCATACACCACTAGTAGAACAATGTCCTATAGATAATCAGTATAAACTTATAACGTATA
TATGGTTAGGTGATCAAAATACTGAAAATGTTTATGTAGTCGGTAGTTTTCCTGGTTGGGATCTGTCTGTAAATCAATTA
CAACGATTGTTACAGACAAATATTTGGTATGTTACGTTTAGGACGAATAAGAGGTTTATTTCAACTTATTATTTTACAGT
AAATGATTTTTTCAAAAATGATTGGATAAAGCGTAGTGAACAGTACCGACTAGACCCATTCAATGAAAATGTATTTGGAG
AAGGTGCCAATAAAGCGTCTGTGTTAAAAATAGATATGGACGTGCAGTATAGCAGTCGTTTTCCTTCAAATCATTATCCA
TCCGGAAAGATTGAAACATATTCTTTTTATAGTTCGATTTTAAATAACACACGTAAAATTCATATTTATACGCCTCATGA
TTATTCTCACAATTCATATCTTCAAGAACTTCTCATTGTATTTGATGGGAATTCATTCATTAATGACCTTTCAATCACAA
AAACACTTAATTATTTAATTTACGAAAAAGAAATCCCATCTTGTATTGCTGTTGCTATAGATCCTGTTGATCGATTAGAA
GAGCTAACTTATAACGATAAAATGAATACATTTTTAATGAAGGAATTACTTCCATGGATTCAAACTAAATATCATGTGTA
TCAAAAAGCAAAACATACAACAATTGCTGGTTTCAGCCTTGGTGGCTTAGCCGCTTTTTATGTAGCACTTCAAAATCCAC
ATATTTTCGGAAATGTGTTGTCAATGTCTGGATCCGTACATTGGAAAAAGGATGATTATGAAAATACAATTCCTTGGATT
GAAAATCAAATTTCATCAATAGATTCTAATGCGACTCATCTCAATTCTTACATAGCAGTAGGTGAACTTGAAAACGAACC
TCTTTTAACGGCTAATAGACGGCTATATAAAGCTTTAGAAGAAAAGAAATACCAAACCACTTATGAAGAGTTTCAAGGCG
GACATGATAGCGTGTGGTGGCGAGAAAAGCTATTCGATGGATTAAGGGCATTAGAACTTACAAAAACGACACTAAAAAAT
AAAAAGGAGAGAGAATCTATGAATCAAGGAGAACTAGATAAAAAACTAAAAAAGCAAGAGATTTTAGTAAAAGATGAGAA
AGTTTGGTCCTATACGTATGAGGATCATATTAGTTCTATCGTTAAAGAGGCAGAAAAGAAAGGGGCTTTCGATCATTTAC
CTGGTAAAGGGAAACCTCTTAATCTTGATAAAGACCTTTCGTACAATCCTGAAAAGCAACTGTATAGAACTTTGAAAAAT
AACCATGTATTACCTAGGTGGATTGAGCTTTCAAAGGAAATTGATGACTTAAAAGAAAAACTAAAAGAAAATACAAATAC
TGCAGAAGCAGCGGATTTAATTCGAACTATTAATAAAAAGGTTTTAGAACATAACCTACTTTGTCCACCAAGTGCGCAAA
AAACGAGGGTGAAAACGGACTTTTAA

Upstream 100 bases:

>100_bases
TCTAATCAATAACTTCTCTAAACACATAACTTACGACTACTTTTATATAGGGATTCTAATGAGAAAACTACATATAGAAT
ACTACAAAGGAGGAAGAGAG

Downstream 100 bases:

>100_bases
CAATTTTTAATAAAGCTATCTCTTGCTATATAATTAAGTAAGGCATTTTCAATTCATTATTAAAGGGAGGCAAATGTGAT
GAAAAATACGTATGAACTTC

Product: hypothetical protein

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSIDSNATHLNSYIAVGELENEPLLTANRRLYKALEEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKN
KKERESMNQGELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF

Sequences:

>Translated_541_residues
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSIDSNATHLNSYIAVGELENEPLLTANRRLYKALEEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKN
KKERESMNQGELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF
>Mature_540_residues
TTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQ
RLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPS
GKIETYSFYSSILNNTRKIHIYTPHDYSHNSYLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEE
LTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIE
NQISSIDSNATHLNSYIAVGELENEPLLTANRRLYKALEEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNK
KERESMNQGELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKNN
HVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=326, Percent_Identity=26.0736196319018, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 63223; Mature: 63092

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEHHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKI
CCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHNSYLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
EEECCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECCHHHHH
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCEEHHH
SMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENEPLLTANRRLYKALE
CCCCCEEECCCCCCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCCCCCCHHHHHHHHHHH
EKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNKKERESMNQGELDKKLKKQE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHH
ILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
HEEECCHHEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
F
C
>Mature Secondary Structure 
TTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEHHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKI
CCCCCCCCCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHNSYLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLE
EEECCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECCHHHHH
ELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCEEHHH
SMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENEPLLTANRRLYKALE
CCCCCEEECCCCCCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCCCCCCHHHHHHHHHHH
EKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNKKERESMNQGELDKKLKKQE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHH
ILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
HEEECCHHEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]