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The map label for this gene is ipdC [H]

Identifier: 218903623

GI number: 218903623

Start: 2379543

End: 2381219

Strand: Reverse

Name: ipdC [H]

Synonym: BCAH820_2507

Alternate gene names: 218903623

Gene position: 2381219-2379543 (Counterclockwise)

Preceding gene: 218903626

Following gene: 218903614

Centisome position: 44.91

GC content: 34.88

Gene sequence:

>1677_bases
TTGAAAACTCAATATACTGTAAGTACATATTTATTAGACCGACTAAGCGAATTAGGAATTGAGCATATTTTTGGTGTCCC
TGGTGATTATAATTTGGCTTTTTTAGATTATGTACTCGCACATAAAAATTTAGAGTGGATTGGCAATTGTAATGAATTAA
ATGCGGCATATGCTGCAGATGGATATGCTCGTATAAAAGGAATAGCAGCTCTTATTACCACCTTTGGCGTTGGAGAATTA
AGCGCCATAAATGGCATTGCTGGTTCATATGCTGAAAATGTACCCGTTATAAAAATAACAGGTACGCCAACAACAACTGT
AATGGAAAATGGGGAGCTCGTTCATCATACGTTAGGCGACGGAAAGTTTAATCACTTTTCCAATATGTATCGAGAAATTA
CTGTTGCACAAACTAATTTAACCCCAGAGCATGCAGTCGAGGAAATTGACCGTGTGTTACGTGCATGTTGGAATGAAAAA
CGTCCTGTTCATATTAATTTACCTATTGATGTGTATAATAAACCAATTAATAAACCTGCAGGACCAATTTTACATAAACC
GATTTTAAGTAATAAAGAAACACTGGATAAAATGCTTCTACATGCCATTTCAAAAATAAATAGCGCAAAGAAACCTATTA
TTTTAGCGGATTTTGAAGTAGATCGTTTTCATGCAAAAGAATATTTATATCAATTTGTAGAAAAAACAGGGTTTCCTATT
GCAACGTTAAGTATGGGAAAAGGAATATTTCCAGAAAAACACCCTCAATTTATAGGGATTTATACTGGTGATGTAAGTTC
TCCATACTTGCGTAAAAGAATTGATGAATCTGACTGTATTATTAGTATTGGTGTGAAGTTAACTGATACTATTACAGGTG
GCTTCACACAAGGTTTTACGAAAGAACAAGTTATTGAAATTCATCCCTACACTGTGAAAATTACAGATAAAAAATACGGG
CCAGTTGTAATGAAAGATGTTTTACAACAGTTAAGTGATGTAATTGAGCATCGAAATGAAGAAACGCTTGATATTAAGCC
ATTTATTTCAGAATCGCTATCTATGACAGAAGAGTTCAATCCAAAAGCACAAATGGTTACACAAAAACGTTTTTGGCAAC
AAATATACCATTTCTTACAAGAAAACGACGTCTTACTTGCAGAGCAAGGAACACCTTTCTTTGGTAGTGCCGCTATCCCT
TTACCAAACGACACTACATATGTAGCGCAACCATTATGGGGATCGATCGGCTATACGTTACCTGCTCTACTTGGTACACA
GCTCGCTAATTTATCGCGGCGCAACATTTTAATTATTGGTGATGGTTCTTTCCAATTAACTGTCCAAGAGTTATCGACCA
TGCTTCGTCAAAATTTAAAACCGATTATATTTTTAATTAATAACAATGGTTATACTGTTGAACGTGCAATTCATGGTCAA
ATTGAACCATATAATGACATACAAATGTGGGAGTACACAAAACTAGCGAACGTATTCGGAACAGAAGAAAAAAGCCAAAC
ATTTAAAGTAGAAAATGAAACAGAGTTACAAGAAGTCTTAACTAAAATAAGTATTGATAAGGATCAACTTACCTTTGTTG
AAGTTGTAATGAGTCAAGGAGATCAGCCTGAATTGTTAGCTAAGCTTGGGAAGAGATTCGGCCAGCAAAATTCTTAA

Upstream 100 bases:

>100_bases
ATGTAAATTATACCACATTCTAGTAATGAATATTTTAATCAATGCTCTAGAGCTGCTTTCGTTTATTACAAGAAAGCAAA
ACGATTAGGAGATGATTCAC

Downstream 100 bases:

>100_bases
TATAAAAAGCATAACCTAATTATATAAAAGGAAAAGGATGGAAGGTGCCACCCTTTTCCTTTTATATATACTATTTTAAG
AACCTTCTTCGACTAACTTC

Product: putative indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPAGPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAQMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAIHGQ
IEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQNS

Sequences:

>Translated_558_residues
MKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPAGPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAQMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAIHGQ
IEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQNS
>Mature_558_residues
MKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGVGEL
SAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEK
RPVHINLPIDVYNKPINKPAGPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
ATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDKKYG
PVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAQMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIP
LPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAIHGQ
IEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQNS

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=558, Percent_Identity=22.7598566308244, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1790104, Length=546, Percent_Identity=21.978021978022, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786717, Length=480, Percent_Identity=23.9583333333333, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1787096, Length=556, Percent_Identity=22.1223021582734, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=25.4132231404959, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=25.4132231404959, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323163, Length=571, Percent_Identity=39.9299474605954, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6323073, Length=571, Percent_Identity=38.5288966725044, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321524, Length=574, Percent_Identity=37.8048780487805, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320123, Length=560, Percent_Identity=35.7142857142857, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6320588, Length=595, Percent_Identity=30.0840336134454, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6323755, Length=521, Percent_Identity=22.4568138195777, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 62805; Mature: 62805

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAAD
CCCEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGD
CHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCC
GKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPINKPA
CCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
GPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
CCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFN
CCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHCC
PKAQMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNDTTYVAQPLWGSIGYTL
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHH
PALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
IEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQG
CCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAAD
CCCEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHHHCC
GYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGD
CHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCC
GKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPINKPA
CCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCCCCC
GPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTGFPI
CCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFT
EEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCC
KEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFN
CCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHCC
PKAQMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNDTTYVAQPLWGSIGYTL
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHH
PALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAIHGQ
HHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCC
IEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQG
CCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCC
DQPELLAKLGKRFGQQNS
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]