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The map label for this gene is tdcB [H]

Identifier: 218903602

GI number: 218903602

Start: 2363055

End: 2364056

Strand: Direct

Name: tdcB [H]

Synonym: BCAH820_2486

Alternate gene names: 218903602

Gene position: 2363055-2364056 (Clockwise)

Preceding gene: 218903601

Following gene: 218903609

Centisome position: 44.56

GC content: 36.83

Gene sequence:

>1002_bases
ATGATAACTAAAAAACTACCATTACATTTAGACGATATTAAAAAAGCTCAAAGCATTCTGGATAGAAATGCTCGTAAAAC
TCCATTAGTAAAATCATTTTATTTGACTAGTAAAACGGGTGGAGAAATTCACTTGAAATTAGAAAACATGCAATTAACAG
GTTCGTTTAAATTCCGTGGTGCGTTTAATAAAATGTCACAGCTGACAGATCAAGAAAAAGAGAGAGGAGTAATTGCTTGT
TCTGCTGGTAATCATGCGCAAGGAATTGCTTTATCTGCTCATTTACTCGGTATTAAAAGTAAAATTGTAATGCCGATTTC
TGCACCTCAGGCGAAAGTTGATGCAACGAAAGGATATGGATCTGAAGTGGTTTTACATGGTGAAACCTTTGATGATGCGA
AGGCAAAATGTGAGGAGATTATTAGAGAAACAGGTGAAACATACTTACATCCATATGACGATGTAGAAGTAATGGCTGGT
CAAGGTACAATAGGATTAGATATTCTTGATGATATGTGGGATGTTGATACGGTCATTGTACCAATTGGTGGAGGAGGAAT
TATTTCTGGAATTGCTGTCGCATTAAAATCTTTTAATCCGTCGATTCATATAATTGGTGTGCAAGCAGAAAATGTTCATG
GGATGAAGGCATCTTATGACAAAGGCAAAATTATAGAACATTATGAGGCACCTACGATAGCAGATGGTTGCGCGGTAAAA
ATACCAGGCAATTTAACTTTTGAAGTTGTAAAAGAATTAGTAGATGATATTGTAACAGTATCAGAAAAAGAGCTGGAAGT
AGCGATGAAAGACTTATTACAACGCGGGAAAGCTGTTGTAGAAGGTGCAGGCGCATTAGCTACGGCTGCTCTACTTGCAG
GGAAAGTGGATACATATATTAAAGAGAAAAAAGTAGTAGCAGTTATATCTGGTGGGAACGTAGACTTACAGCGCATATCG
AGTGTTTGTGAACAATTTTTTGTGGCGAATGAAGTGAAATAG

Upstream 100 bases:

>100_bases
AGGTACATATATAAAGACTTTTTCTTAATATAGATGGTTTCGTATAAAGAAGTTGCTACATACGAAAACTTAGGAAGAGA
ACATTGGAAGAGGTGTTAGT

Downstream 100 bases:

>100_bases
TTTTATGAAAAAGGAGCTAAGTGAAATTATATTAGCTCCTTTTTCATTATGTTTGTGCGGGAGTAAATAATGACTCCATT
TTTACTTTGCTCTTTTCTCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MITKKLPLHLDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Sequences:

>Translated_333_residues
MITKKLPLHLDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK
>Mature_333_residues
MITKKLPLHLDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=35.8730158730159, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=25.705329153605, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=27.1523178807947, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=59.190031152648, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI1790207, Length=304, Percent_Identity=42.4342105263158, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI2367138, Length=269, Percent_Identity=24.5353159851301, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=42.2077922077922, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17537387, Length=318, Percent_Identity=34.5911949685535, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=305, Percent_Identity=29.1803278688525, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=40.5144694533762, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=307, Percent_Identity=37.4592833876222, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=24.1992882562278, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=37.5776397515528, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645328, Length=226, Percent_Identity=38.4955752212389, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35800; Mature: 35800

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKKLPLHLDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTVIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITKKLPLHLDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATKGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTVIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGKIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELEVAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA