Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 218903366

GI number: 218903366

Start: 2140572

End: 2141774

Strand: Direct

Name: adhB [H]

Synonym: BCAH820_2250

Alternate gene names: 218903366

Gene position: 2140572-2141774 (Clockwise)

Preceding gene: 218903365

Following gene: 218903367

Centisome position: 40.37

GC content: 36.16

Gene sequence:

>1203_bases
TTGCAAGAAGTTGCTGAGTTTCGTATGCCGAAGTCTGTATTATATGGAAGAAATTCTCTTGAAAAGCTGTGGGAACAATC
TAAGAAATTCGGGAAAAGAGCGTTTATAGTTACGGATACAATTATGGAGGATTTAGGATATGTTGAGAGGTGTATACAAC
AATTAAATACGAAAGGTATAACTGTTATTACATATAATAAAGTAAATGCTGAGCCTACAAATATACACGTGTTAGAGGCG
TTAACTATTTGTAAAGAAGGAAAGTGTGATTTTATAATCGGTCTTGGTGGTGGAAGTTGTATTGATGCAGCAAAAGCAGT
TGCGGTGTTATATACAAATGGCGGAGAAGTGGAAGATTATGTCCAAAAGGATAGGGAAATAGACAATGATCCGCTACCAC
TTATTGCAATCCCAACAACCTCTGGAACTGGATCGGAAGTAACAAGTGTAGCAGTAATTACGAATAAACGAACAGATGTA
AAAATGATGATGAAGCATCCGAGTTTTACCCCGCAAGTAGCAATTATTGACCCAATTTTAACACGTTCGGTACCACCTCA
CATTACAGCAGCAACAGGGATAGATGCTTTATGTCATGCAGTCGAAGCATATATTTCTAAAGTTTCACAATCACTTACAG
ATGTATTAGCTCTTTCCGCTATTGAAAGTATTATGAAATATTTACGTATTGCATATGAAGATGGAGAGAATATGGAGGCA
AGAGAAGCGATGATGATAGCGTCCTTACAAGCTGGAATTGCATTTTCTAATGCATCTGTTACATTAGTTCATGGCATGTC
GAGACCAGTAGGAGCATTATTTCATGTACCACATGGTATATCGAATGCAATACTATTACCTACAGTTTTAGAGTATACAA
AAGGTAGTGCGGTAAAAAGACTAGCGGAAATTGGCCGCTGTTTAAATAAAGATTTGTATTCCTATTGTGATGAAGAAGTA
GCCGACTACACGCTGGGGGAAATAAAAAAACTTTGTTTTGATCTTCATATTCCAAATTTAAAAGAATACGGAATTGGTGA
GCTTGAGTTTGAAAAAGCTATTTCTAAAATGGCGTCAGATGCAATTGAAAGTGGAAGTCCAGCGAATAACCCACGTGTGC
CATCATATGATGAAATTAAACAGTTGTATCGAGAATGTTTTCATTATAAATATGAAGATTCAATAAAAACATTAGGGAAT
TAA

Upstream 100 bases:

>100_bases
GCTGTGTTTTTAGTTATTGCATTCTATACAGTAACAGGAATTTATTAAATAGATATTTTATAAACGAAAATATGAATTAG
GGTAAGAAGGGGTGGAGTAC

Downstream 100 bases:

>100_bases
TTTCAGAATATTCTTATAAAATTTCCTTGGAAATAGTTAAAACAAGGCTTTATATTTCAAACGTAAAGTCTTGCTTTATT
ATGTATAATATACATAATAA

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQEVAEFRMPKSVLYGRNSLEKLWEQSKKFGKRAFIVTDTIMEDLGYVERCIQQLNTKGITVITYNKVNAEPTNIHVLEA
LTICKEGKCDFIIGLGGGSCIDAAKAVAVLYTNGGEVEDYVQKDREIDNDPLPLIAIPTTSGTGSEVTSVAVITNKRTDV
KMMMKHPSFTPQVAIIDPILTRSVPPHITAATGIDALCHAVEAYISKVSQSLTDVLALSAIESIMKYLRIAYEDGENMEA
REAMMIASLQAGIAFSNASVTLVHGMSRPVGALFHVPHGISNAILLPTVLEYTKGSAVKRLAEIGRCLNKDLYSYCDEEV
ADYTLGEIKKLCFDLHIPNLKEYGIGELEFEKAISKMASDAIESGSPANNPRVPSYDEIKQLYRECFHYKYEDSIKTLGN

Sequences:

>Translated_400_residues
MQEVAEFRMPKSVLYGRNSLEKLWEQSKKFGKRAFIVTDTIMEDLGYVERCIQQLNTKGITVITYNKVNAEPTNIHVLEA
LTICKEGKCDFIIGLGGGSCIDAAKAVAVLYTNGGEVEDYVQKDREIDNDPLPLIAIPTTSGTGSEVTSVAVITNKRTDV
KMMMKHPSFTPQVAIIDPILTRSVPPHITAATGIDALCHAVEAYISKVSQSLTDVLALSAIESIMKYLRIAYEDGENMEA
REAMMIASLQAGIAFSNASVTLVHGMSRPVGALFHVPHGISNAILLPTVLEYTKGSAVKRLAEIGRCLNKDLYSYCDEEV
ADYTLGEIKKLCFDLHIPNLKEYGIGELEFEKAISKMASDAIESGSPANNPRVPSYDEIKQLYRECFHYKYEDSIKTLGN
>Mature_400_residues
MQEVAEFRMPKSVLYGRNSLEKLWEQSKKFGKRAFIVTDTIMEDLGYVERCIQQLNTKGITVITYNKVNAEPTNIHVLEA
LTICKEGKCDFIIGLGGGSCIDAAKAVAVLYTNGGEVEDYVQKDREIDNDPLPLIAIPTTSGTGSEVTSVAVITNKRTDV
KMMMKHPSFTPQVAIIDPILTRSVPPHITAATGIDALCHAVEAYISKVSQSLTDVLALSAIESIMKYLRIAYEDGENMEA
REAMMIASLQAGIAFSNASVTLVHGMSRPVGALFHVPHGISNAILLPTVLEYTKGSAVKRLAEIGRCLNKDLYSYCDEEV
ADYTLGEIKKLCFDLHIPNLKEYGIGELEFEKAISKMASDAIESGSPANNPRVPSYDEIKQLYRECFHYKYEDSIKTLGN

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=381, Percent_Identity=30.1837270341207, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI87082107, Length=390, Percent_Identity=36.6666666666667, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=35.5263157894737, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI1789163, Length=380, Percent_Identity=32.6315789473684, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787493, Length=411, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=23.7430167597765, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17537053, Length=422, Percent_Identity=28.1990521327014, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=393, Percent_Identity=35.8778625954198, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24657991, Length=345, Percent_Identity=30.7246376811594, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 44046; Mature: 44046

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEVAEFRMPKSVLYGRNSLEKLWEQSKKFGKRAFIVTDTIMEDLGYVERCIQQLNTKGI
CCCHHHHCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCE
TVITYNKVNAEPTNIHVLEALTICKEGKCDFIIGLGGGSCIDAAKAVAVLYTNGGEVEDY
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHEEEEEEECCCCHHHH
VQKDREIDNDPLPLIAIPTTSGTGSEVTSVAVITNKRTDVKMMMKHPSFTPQVAIIDPIL
HHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEECHHH
TRSVPPHITAATGIDALCHAVEAYISKVSQSLTDVLALSAIESIMKYLRIAYEDGENMEA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
REAMMIASLQAGIAFSNASVTLVHGMSRPVGALFHVPHGISNAILLPTVLEYTKGSAVKR
HHHHHHHHHHHCEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHH
LAEIGRCLNKDLYSYCDEEVADYTLGEIKKLCFDLHIPNLKEYGIGELEFEKAISKMASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
AIESGSPANNPRVPSYDEIKQLYRECFHYKYEDSIKTLGN
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MQEVAEFRMPKSVLYGRNSLEKLWEQSKKFGKRAFIVTDTIMEDLGYVERCIQQLNTKGI
CCCHHHHCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCE
TVITYNKVNAEPTNIHVLEALTICKEGKCDFIIGLGGGSCIDAAKAVAVLYTNGGEVEDY
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHEEEEEEECCCCHHHH
VQKDREIDNDPLPLIAIPTTSGTGSEVTSVAVITNKRTDVKMMMKHPSFTPQVAIIDPIL
HHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEECHHH
TRSVPPHITAATGIDALCHAVEAYISKVSQSLTDVLALSAIESIMKYLRIAYEDGENMEA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
REAMMIASLQAGIAFSNASVTLVHGMSRPVGALFHVPHGISNAILLPTVLEYTKGSAVKR
HHHHHHHHHHHCEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHH
LAEIGRCLNKDLYSYCDEEVADYTLGEIKKLCFDLHIPNLKEYGIGELEFEKAISKMASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
AIESGSPANNPRVPSYDEIKQLYRECFHYKYEDSIKTLGN
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]