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The map label for this gene is copA [H]

Identifier: 218903054

GI number: 218903054

Start: 1841865

End: 1843514

Strand: Direct

Name: copA [H]

Synonym: BCAH820_1937

Alternate gene names: 218903054

Gene position: 1841865-1843514 (Clockwise)

Preceding gene: 218903053

Following gene: 218903055

Centisome position: 34.73

GC content: 35.15

Gene sequence:

>1650_bases
ATGAAGCGATATATATTAACAGCGGTTACAGTCTCAGTAATATTTTTAATTGCTGCATGTTCTGTGACGACAAATACAAC
AAATGACCATAAAAATAGGAATGATAAAAAAACTAAACAAACTGAAACGGCTACAAAACCATTGGAAATTGTTAAGGGGC
CAGAAGTTACTTTAATAGCGAAAGAAAAAAAGCAAAAATTAAGTAACGGTGTTATTGTTCCGGTCTGGACATTTAATGGC
TCATCTCCTGGTCCGGAAATTCGGGTGAAAAAAGGTGAAAAGGTGAAAGTGACATTAAAAAATGAACTATCTGCACCAGT
ATCTATTCACTGGCATGGGTATCCTGTCCCAAATGACATGGATGGAATTCCAGGTGTGACGCAAGATGCAGTCGAACCAG
GAAAAAGTTTCACTTACGAATTTGAAGCGAACGTACTAGGAACGTACTGGTATCATTCACATCAAGATTCTGTAAATCAA
TTAGATAGAGGATTATATGGTGCTTTCGTTGTAGAAGATACAAATGAAAAGTATGATAAAGATTACACATTAATGTTAGA
TGAATGGATAACGGATAAAGAAGAGATGAATAAACAGTTAAAAGAAATGACAAAAGGAAAAACAGAAAAAGCAGACGGTA
ATAAATCTAGTAAGGGTAATGAAAATACGAAAAAGAATGATGATAAGAACAGCATGGATCATTCTGGTATGGACAGTGAT
AAAAAAGACTCTGGCAATATGGCAGGAATGGACCATGGAAATATGAAGATGGAAGGTCATGATATGAGTATGTATGATTT
ATTCACAATCAACGGAAAAAGTGGTGATTTAGTAGCGCCATTGAAAGTGAATAAGGGAGATAAAGTTCGTCTTCGACTCG
TTAATGCCGGTTATCTATCACATAATATACATGTTCACGGTCATGACATTAAAGTGATTGCAACAGATGGTCAACCAATA
AACGACCCAAAAGTTATAAAGGATAAAGTAATTTCAATCGCACCGGGTGAACGTTATGATGTTGAGTTTACTGCTAATAA
TCCTGGAAAATGGTATGTTGAAGACCATTCAGAAAATAAAGGTGCAAAAGGAATGAAGGCTATTATTGAATATGATGGTA
GCAAAGAGATGAAAGATATAGCAGATGAAAAAGAAAAATTATCGAAATTAGATATGACGAAATATGGTGCTAAAAAATTA
GGTGGTTTCACGTTAAATCAGCAGTATACTGCCACATATAATATGGACTTAAATACGCAAATGAATGGAAATGAAATGGT
ATATACAATTAACGGGAAGGTGTTTCCGGATATTGACCCAGTTCAAGTGAAAAAGGATGATTTAGTAAAAGTGAAATTAG
TAAATCGTTCCAAAATGGATGATCACCCAATGCATTTACATGGTCACTTCTTCCAGGTGTTGAGTAAAGATGGAAAACCG
GTAGAAGGTTCTCCAATTGTAAAAGATACATTGAACTTAAAACCGGGAGAAGAATATGAAGTAGCCTTTGTAGCAGACAA
TCCGGGTGAGTGGATGTTTCATTGTCATGATTTACATCATGCTTCAGCAGGGATGGTAACGGAAGTGAAATATAAAGATT
ATAAATCTGACTATGTTCCAAACCCAAACATTCCTAATAAGCCAGAATAA

Upstream 100 bases:

>100_bases
CAATTTGGGGCGTCCTTTTATTTTTCCCATTTTAAATCTCCTTATTTTCTTGAAAATCATCTTCTAGAATGATTTTGAAA
AAGAAAAGGAGGGATTTTCC

Downstream 100 bases:

>100_bases
TATGAAAAACATGTAGTTTATTAATGATGTAAAGCAGTTATCTTTAATAGGTGGCTGCTTTTATATGTCATGTTGTGAAT
TAGGAATATTATTTTTATAA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDSD
KKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQPI
NDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKL
GGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKP
VEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Sequences:

>Translated_549_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDSD
KKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQPI
NDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKL
GGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKP
VEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE
>Mature_549_residues
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEKKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGAFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDSD
KKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQPI
NDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKL
GGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKP
VEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=518, Percent_Identity=25.0965250965251, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=525, Percent_Identity=24.7619047619048, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321067, Length=506, Percent_Identity=23.9130434782609, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323703, Length=125, Percent_Identity=40, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221330000, Length=304, Percent_Identity=27.6315789473684, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585842, Length=326, Percent_Identity=27.3006134969325, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281360167, Length=326, Percent_Identity=27.3006134969325, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI221329998, Length=326, Percent_Identity=27.3006134969325, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28574104, Length=352, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650186, Length=153, Percent_Identity=34.640522875817, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859919, Length=145, Percent_Identity=33.7931034482759, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 61603; Mature: 61603

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CCCEEEHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEKKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGAFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDSD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLS
CCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCEEE
HNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENK
EEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCCCC
GAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLNTQ
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEECCE
MNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKP
ECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCCCC
VEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVP
CCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCC
NPNIPNKPE
CCCCCCCCC
>Mature Secondary Structure
MKRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CCCEEEHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEKKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGAFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDSD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLS
CCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCEEE
HNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENK
EEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCCCC
GAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLNTQ
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEECCE
MNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKDGKP
ECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHCCCCCC
VEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVP
CCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCC
NPNIPNKPE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]