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The map label for this gene is norM [H]

Identifier: 218902590

GI number: 218902590

Start: 1394034

End: 1395395

Strand: Reverse

Name: norM [H]

Synonym: BCAH820_1472

Alternate gene names: 218902590

Gene position: 1395395-1394034 (Counterclockwise)

Preceding gene: 218902592

Following gene: 218902588

Centisome position: 26.31

GC content: 36.27

Gene sequence:

>1362_bases
ATGAAAGAAACTAATTCATTCTCACAAAAATTAAAGCAATTTGTATTACTATTTTTCCCGATTTTCGTGACGCAAATGTC
ATTATTTGCAATGAGTTTTTTCGATACGACCATGTCAGGACATGCAAGCCCTATTGATTTAGCAGGTGTTGCTATCGGAA
CAAGTATATGGATTCCAGTTAGTACGGGATTAACAGGAATTTTGATGGCTACGACTCCAATTGTTGCACAACTCGTTGGA
TCTAAGAAAAAAGAGGATGTTCCTCACGTTGTCATACAAGCAGTTTATTTAGCAATTTGTGCTAGCTTCGTCGTTATCCT
TATAGGTTTATTTACTGTTACACCTATTTTAAATGGCATGCGATTAGAAGAACCTGTAGAACGTATTGCGGCACAATTTT
TAAGTATTATCGCAATTGGAATTATCCCTTTATTTACTTACACAGTTTTACGCGGATTTATTGATGCATTAGGAAAAACT
CGTACAACGATGATCATTACATTACTATCATTACCAATCAACGTAGTATTAAATTATGTATTAATTTTCGGTAACTTCGG
TTTTCCAAAACTCGGTGGTGTCGGAGCAGCAATTGCTTCTGCAGCAACCTATTGGTGCATTTTAATTATTACCGTTATGA
TTATTCGTACGAAAGAGCCTTTTGCATCTTTCAATATCTTTAAACAATTATATCGTCCTTCCCTTTCGAGTTGGAAAGAA
TTCTTAAAACTTGGCGTCCCTATCGGATTTGCTATCTTTTTTGAAACGAGTATTTTTGCTGCGGTAACACTTATGATGAG
TAATTTTAGTACGACAACAATTGCAGCTCATCAGGCAGCTATGAACTTCGCTTCCTTGCTATATATGACTCCTTTAAGTT
TAGCAATGGCAATGACCATCGCTGTTGGATTTGAAGTTGGAGCGAAACGATATAATAACGCAAAACAGTATGGATTTATC
GGGATTGGATTAGCACTGGCATTCGCCCTATTGTATTCCATTCTTCTTTACTTCTTTGATGATGAAATTGCTTCTATTTA
TACGACAGATATACAAGTTCATCATTTAGCAAAAGAATTTCTTATATTTGCGATTTTATTTCAAATTTCAGATGCAATTG
CAACTCCTGTACAAGGGGCACTACGTGGTTATAAAGATGTAAATGTCGCCTTAATTATGACATTAATCGCCTATTGGGTA
ATAGGTCTCCCTCTCGGTTACATATTAGCAACTTATACTGACTGGGCAGCAAAAGGATATTGGATTGGTCTTATTATCGG
TCTAGCATTTGGAGCAACCTTCCTCCTCATCCGTCTCTTTCAAGTTCAGAGAAAATATACAACGCAAAACAGCCGCTCAT
AA

Upstream 100 bases:

>100_bases
TTTATTGAATTTACATGCTGTATGCGCGTATTTCTTTTCTATTTTTTGATTAAATTGTATGATAGTAAGAGTTTGGTTTT
TTTAGCGGAAAGGGGATTTT

Downstream 100 bases:

>100_bases
TATAGCGGTTGTTTTCTTTATGCATATTTTTTCTTGTAACGTATAACATAATGAAAAAGAAAGGTGGATACATATGGACG
AAAAAGAAAAAAAGCAATCA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKETNSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFNIFKQLYRPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS

Sequences:

>Translated_453_residues
MKETNSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFNIFKQLYRPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS
>Mature_453_residues
MKETNSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFNIFKQLYRPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=450, Percent_Identity=22.4444444444444, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI153792564, Length=408, Percent_Identity=23.7745098039216, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38261960, Length=438, Percent_Identity=22.3744292237443, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI48994890, Length=446, Percent_Identity=35.6502242152466, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI226510954, Length=458, Percent_Identity=22.4890829694323, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=410, Percent_Identity=23.4146341463415, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321821, Length=394, Percent_Identity=22.5888324873096, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49797; Mature: 49797

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA