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The map label for this gene is prsA [H]

Identifier: 218902361

GI number: 218902361

Start: 1189185

End: 1190042

Strand: Reverse

Name: prsA [H]

Synonym: BCAH820_1243

Alternate gene names: 218902361

Gene position: 1190042-1189185 (Counterclockwise)

Preceding gene: 218902362

Following gene: 218902358

Centisome position: 22.44

GC content: 33.68

Gene sequence:

>858_bases
ATGAGAGGGAAACATATTTTCATTATTACTGCACTAATAAGTATATTAATGCTAGCTGCTTGCGGGCAAAAAAATAGCTC
GGCTACAGTCGCTACGGCAACAGACTCAACCATTACGAAGAGCGACTTCGAAAAGCAGTTAAAAGATCGTTACGGAAAAG
ACATGTTATACGAAATGATAGCGCAAGACGTTATCACGAAAAAATATAAAGTATCTGACGATGATGTAGAGAAAGAAGTA
CAAAAAGCGAAAAGTCAATACGGAGATCAATTCAAAAACGTGTTGAAAAACAACGGTTTAAAAGATGAAGCTGATTTTAA
AAATCAAATTAAGTTCAAACTTTCTATGAATAAAGCAATTAAACAAAGTGTTACAGAAAAAGACGTGAAAGACCACTACA
AACCAGAAATTAAAGCGAGCCACATTTTAGTAAGTGACGAAAATGAAGCAAAAGAAATAAAGAAAAAATTAGATGCTGGT
GCTTCATTTGAAGAACTAGCAAAACAAGAATCGCAAGACCTACTATCAAAAGAGAAAGGCGGAGACCTCGGATACTTCCA
TTCAGGTGCAATGACACCTGAATTTGAAACAGCTGCCTACAAACTAAAAATTGGTCAAATTAGTGATCCTGTCCAATCAC
CAAATGGTTATCACATTATTAAACTAACTGGTAAAAAAGATCTAAAACCTTACGATGAGGTAAAAAACTCTATTCGCAAA
AACTTAGAGGAAGAACGTACTGCTGATCCTATATTTGGTAAAAAATTATTACAAAGTGAATTAAAAAAAGCAAATATTAA
AATAAACGATAGTGAGTTGGAAGATACGTTTACTATTGTTTCTCCGCAAGGAAATTAA

Upstream 100 bases:

>100_bases
TGTACTTTTTTACATTTTACAGGAAAAAACATTAAAAATTCACTTCATGTTCACTTCTATATTCTACAATAGCGATAATA
TATTCGGATGAGGTGTTAGC

Downstream 100 bases:

>100_bases
AAAAGCACAACCTTATTTTTTCAGATAAGGTTGTGTTTTTTAATCTTTCATCAATATTTTCAACTTTTTCTTCAAGCTTT
TATAATGCCAATTGATGTGA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVEKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN

Sequences:

>Translated_285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVEKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
>Mature_285_residues
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMIAQDVITKKYKVSDDDVEKEV
QKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAIKQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=166, Percent_Identity=28.3132530120482, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=105, Percent_Identity=43.8095238095238, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32063; Mature: 32063

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMI
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVEKEVQKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHHH
KQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
CCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCC
>Mature Secondary Structure
MRGKHIFIITALISILMLAACGQKNSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMI
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVEKEVQKAKSQYGDQFKNVLKNNGLKDEADFKNQIKFKLSMNKAI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEHHHHHH
KQSVTEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFHSGAMTPEFETAAYKLKIGQISDPVQSPNGYHIIKLTGKKDLKPYDEVKNSIRK
CCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERTADPIFGKKLLQSELKKANIKINDSELEDTFTIVSPQGN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539 [H]