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The map label for this gene is hemH2 [H]

Identifier: 218902353

GI number: 218902353

Start: 1179636

End: 1180595

Strand: Direct

Name: hemH2 [H]

Synonym: BCAH820_1235

Alternate gene names: 218902353

Gene position: 1179636-1180595 (Clockwise)

Preceding gene: 218902352

Following gene: 218902354

Centisome position: 22.25

GC content: 37.19

Gene sequence:

>960_bases
ATGAAAAAGAAAAAAATAGGTTTACTCGTAATGGCGTATGGAACGCCGGATTCATTAGATGAAGTAGAGGCATATTATAC
ACATATTCGTCATGGGCGTAAGCCATCCGAAGAAGCGCTCCAAGATTTAATTGGGCGCTATAAAGCAATTGGCGGAATTT
CACCGCTTGCAAAAATTACGAAAGAGCAAGCGCATAAATTAACAGACTCAATGAATAATATGTTTACAGAGTATGAATTT
AATTGTTACTTAGGCTTAAAACATACTGCTCCGTTTATAGAAGATGCAGTAGAAGAGATGAAGCGCGATGGAATTGAGCA
AGCGATTAGTATCGTATTAGCGCCGCATTATTCTACCTTTAGCATTAAGGCATATAACGAGCGTGCAATTCGTCTTTCGG
AGGAAATAGGTGGTCCTGTTATTGAGCCGATTGACCAATGGTACGATGAACCGAAGTTTATTTCGTATTGGGCAGATCAA
ATAAAAGAAACATTTACAAAAATTGAAGATAAAGGGAAAGCGGTCGTAATTTTTTCAGCGCATAGTTTACCAGAAAAAAT
TATTGCAGCAGGTGACCCTTATGTGGAGCAATTGCAACATACAGCGGATTTAATCGCAGCAGCTGCAAACATCCAAAACT
ATACAATTGGTTGGCAAAGTGCCGGAAATACACCTGATCCATGGATTGGACCGGATGTGCAAGATTTAACGAGAGATTTA
TTTGAAGAGCATAGATATGAATCTTTCATATATTGCCCAGTCGGTTTTGTGGCAGAGCATTTAGAAGTTTTATATGACAA
CGATTACGAGTGTAAAGTTGTGACGGATGAATTAAATGCTGCGTATTTTAGACCAAATATGCCGAATGCGCAATCTACAT
TTATTGATTGTTTAGCTACAATTGTTTCCAGAAAAATGAAAGAAATAGTTGACAAAGAACTAATTTTGAATAATAATTAA

Upstream 100 bases:

>100_bases
TTTAGAATAATTATCTTTACGTACTTATTATTAGTTGTTATAATTGGAAACAAATGTTCTTGAAAAAGATTCTCATTTAT
AAAATTGAGGTGTTATATAG

Downstream 100 bases:

>100_bases
TTTATAATAATTTTAAATAAATAATAATTACTACGAAAGAAAGAGGAGGATCCCCCTAGATGAATCCAAATAATCGCTTA
ACAACAAACCAAGGTGCTCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKGKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN

Sequences:

>Translated_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKGKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN
>Mature_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQ
IKETFTKIEDKGKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEHRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=343, Percent_Identity=28.2798833819242, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI60499021, Length=342, Percent_Identity=28.3625730994152, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1786681, Length=283, Percent_Identity=22.9681978798587, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=22.8658536585366, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=26.8882175226586, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=26.0700389105058, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=30.1775147928994, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36269; Mature: 36269

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQIKETFTKIEDKGKAVVIFSA
EEEECCCHHEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEHRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKMKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIEPIDQWYDEPKFISYWADQIKETFTKIEDKGKAVVIFSA
EEEECCCHHEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEHRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKMKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]