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The map label for this gene is ntdR [H]

Identifier: 218902282

GI number: 218902282

Start: 1112469

End: 1113482

Strand: Direct

Name: ntdR [H]

Synonym: BCAH820_1164

Alternate gene names: 218902282

Gene position: 1112469-1113482 (Clockwise)

Preceding gene: 218902281

Following gene: 218902284

Centisome position: 20.98

GC content: 38.76

Gene sequence:

>1014_bases
GTGTCGACTATAGAGGACGTGGCGAAATTAGCGGGGTTATCAAGGACAACGGTTTCTAGGGTGATTAATAATCATCCATA
TGTTTCAGATGAGAAGAAAAAAAGGGTTCAATTAGCAATGAAGCATTTAGGTTTCGTTCCTAATTCTGCGGCGAGAAGGC
TTCGTAAACAAAAGACGGAAACAATTGCGGTGCTAGTTCCAAGGATTACAAATCCTTTCTTCAGTAGATTTATTGAAGCA
ATCGAGATTGCTGCTTCTGAACATAAATATAAACTGATTATTTGTCAAACAAGATATTTACCAGAAAAAGAGATGGAGTA
CTTACAATTATTATCTACGAAACAAGTGGATGGGATTATTCTATGTTCACTAGAAAATCCATGGGAAGATGTAGAGCCAT
ACTTACAACACGGTCCAATCGTGTTATGTAATGAATATATTGAGGAAGCAAATATTCCAACAGTGAAGTTCGATCATGCG
CAAGGAGCATACATAGCTGCGAAGCATGTGTTAGAACAAGGATATCGTAATCTTATTTTTTGCCGTGGTAACGAAACCAA
AGTGGTTAGCCAACAGCGAAAAATGGGCTTTTTACGTGCCATAACGGAAAAGAGCCGCCAAGTAGAAGCAATCGATTTTC
TTGAAAACGCTTTCTCTTGGGAGGATGGAAAACGAATATTCCATGAAGTATTAAAGGACAAAAAAAATCCTACCGCGATT
TTGGCAGGAGGCGATGAGGTAGCAGCTGGAATTATTTCAGAGGCGAAACGCCATGATTGGAGCATTCCAGATGATCTCGC
TGTTATCGGTTTTGATAATCAAATTTTATCACAGATTACAGAACCAGGTATTACGACAATTGAACAGCCAATCGATGAGA
TGGCCCGAAAAGTTGTCGACCTAATGATGGATAAAATCCATACGAAAAATTATCGAAAAAAAGAATTGTATGAGTTTGAA
CTGGAGCTCTTGGTGAAAGGTTCAACGATGAAGGATACGATGTTATTAGCCTAG

Upstream 100 bases:

>100_bases
TATTAATATAGTAAAATCATAAGAAGCCGTATTGCAGTTTCCAATAATATACTATATAATCAATTTAAGAAAACGTTTTC
ATGCAAAGGGGGAGAATTTC

Downstream 100 bases:

>100_bases
TAGACTATGTCTGCTAGGTTTTTTTCTGTTCACAAACTACTATTCTTCGTGAACGCAGTCATCACATTTGTTATGATAAG
CTTCGTGCTGCTCATCAATT

Product: sugar-binding transcriptional regulator, LacI family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEA
IEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHA
QGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAI
LAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFE
LELLVKGSTMKDTMLLA

Sequences:

>Translated_337_residues
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEA
IEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHA
QGAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAI
LAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFE
LELLVKGSTMKDTMLLA
>Mature_336_residues
STIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTETIAVLVPRITNPFFSRFIEAI
EIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGIILCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQ
GAYIAAKHVLEQGYRNLIFCRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAIL
AGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVDLMMDKIHTKNYRKKELYEFEL
ELLVKGSTMKDTMLLA

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=329, Percent_Identity=31.9148936170213, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787948, Length=316, Percent_Identity=31.3291139240506, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=27.3584905660377, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=30.2325581395349, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788474, Length=304, Percent_Identity=27.9605263157895, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI48994940, Length=329, Percent_Identity=24.3161094224924, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789068, Length=327, Percent_Identity=23.5474006116208, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=26.4984227129338, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=22.884012539185, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786268, Length=333, Percent_Identity=24.6246246246246, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790689, Length=312, Percent_Identity=23.7179487179487, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786540, Length=325, Percent_Identity=24, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787906, Length=324, Percent_Identity=20.9876543209877, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789456, Length=317, Percent_Identity=22.0820189274448, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38518; Mature: 38387

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTE
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGII
EEEEEECHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
LCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQGAYIAAKHVLEQGYRNLIF
EEECCCCHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEE
CRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEE
LAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVD
EECCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
HHHHHHHCCCCHHHHHHHHEEHHEEECCCCCCHHCCC
>Mature Secondary Structure 
STIEDVAKLAGLSRTTVSRVINNHPYVSDEKKKRVQLAMKHLGFVPNSAARRLRKQKTE
CCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TIAVLVPRITNPFFSRFIEAIEIAASEHKYKLIICQTRYLPEKEMEYLQLLSTKQVDGII
EEEEEECHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEE
LCSLENPWEDVEPYLQHGPIVLCNEYIEEANIPTVKFDHAQGAYIAAKHVLEQGYRNLIF
EEECCCCHHHHHHHHHCCCEEEEHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEE
CRGNETKVVSQQRKMGFLRAITEKSRQVEAIDFLENAFSWEDGKRIFHEVLKDKKNPTAI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEE
LAGGDEVAAGIISEAKRHDWSIPDDLAVIGFDNQILSQITEPGITTIEQPIDEMARKVVD
EECCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LMMDKIHTKNYRKKELYEFELELLVKGSTMKDTMLLA
HHHHHHHCCCCHHHHHHHHEEHHEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]