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The map label for this gene is hemE [H]

Identifier: 218902270

GI number: 218902270

Start: 1098009

End: 1099055

Strand: Direct

Name: hemE [H]

Synonym: BCAH820_1152

Alternate gene names: 218902270

Gene position: 1098009-1099055 (Clockwise)

Preceding gene: 218902269

Following gene: 218902271

Centisome position: 20.71

GC content: 39.45

Gene sequence:

>1047_bases
TTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTGATTATGTGCCAGCATGGTATATGCG
TCAAGCAGGTCGTTCGCAGCCGGAATATAGAAAGATCAAAGAAAAGTATTCTTTATTTGAAATTACACATAATCCAGAGT
TATGTGCTTACGTTACAAAACTACCAGTTGATCAATATAACGTAGACGCAGCAATTCTTTATAAAGATATTATGTCACCA
CTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGATAATCCAATCCGTTCTTTACAAGA
CGTAGAAAAACTAGGGGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATACAATTCGTTTATTAACGACTGAAA
TGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTATATGATTGAAGGCGGTCCATCTCGT
AACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTTGCTTTAATGGATAAGCTAGCAGATATGGT
TATTACATATTTGAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCGATTCTTGGGTTGGAACAGTAAACG
TAGCAGATTACCGCGTATTTATTAAACCAGCAATGGAGCGTATTTTTGCAGAAGTTCGCACGATGGGTGTACCGATGATT
ATGCACGGCGTAGGAGCTCCACACTTAGTGAATGAGTGGCACGACTTACCGCTTGATGTAGTCGGTTTAGACTGGCGTTT
ACCAATTGAAGAAGCACGTGCACGCGGCGTTCACAAGGCGGTACAAGGGAATATGGATCCGTCATTCTTACTTGCACCAT
GGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAGCAGCCAGGTTATATCTTTAACTTAGGTCAC
GGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAGTTAGC
GAAGTAA

Upstream 100 bases:

>100_bases
GTACATAATATTATGCATTTTGTTTTTACAAGCTGTATAGTAAAAAAAGATAAATATCGAACGTATTCGAAGCATTGTGG
TAAGGAAGGGAGCTAGGGTC

Downstream 100 bases:

>100_bases
AGGAGCATTGCTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATATGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAPHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Sequences:

>Translated_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAPHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK
>Mature_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAPHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=36.2857142857143, Blast_Score=218, Evalue=4e-57,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=40, Blast_Score=246, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=32.4786324786325, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=33.4302325581395, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=33.4302325581395, Blast_Score=204, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39239; Mature: 39239

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALM
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAPHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALM
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAPHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA