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The map label for this gene is lmrB [H]

Identifier: 218902234

GI number: 218902234

Start: 1067482

End: 1068930

Strand: Direct

Name: lmrB [H]

Synonym: BCAH820_1116

Alternate gene names: 218902234

Gene position: 1067482-1068930 (Clockwise)

Preceding gene: 218902233

Following gene: 218902238

Centisome position: 20.13

GC content: 39.06

Gene sequence:

>1449_bases
ATGAATGCTCAAACTGCACCTGTTTCTTCGCAGTCAAAGGAGTTTGACAATGTGAAAAGACTCCCCATTTTAATATCGAT
GATCATTGGGGCATTTTTTACCATTTTGAATGAAACATTATTGAACGTTGCTTTTCCGCAATTGATGATTGAGTTGAATG
TAACACCGTCAACTCTTCAATGGCTTTCAACAGGGTACATGCTTGTAGTTGCTGTGCTAATTCCAGCTTCTGCTTTATTA
GTACAATGGTTTACAACAAGACAAGTATTCATAGGTGCTATGGTAGTCTTTACTTTCGGTACACTTGTAAGTGCAATTGC
GCCTGGATTTTCTATATTATTAATGGGGCGCTTGTTACAAGCAGCAGGTACGGGATTAATAATGCCCGTATTAATGAATA
CGATTCTCCTTCTATATCCTCCTGAAAAGAGAGGAGCGGCAATGGGGAGTATTGGGCTTGTAATCATGTTCGCTCCTGCT
ATTGGACCGACACTTTCAGGTATCATTTTGGAAACGTTGAACTGGAGATGGCTATTTTATATCGTTCTTCCATTCGCTAT
TTTTTCTATCGTTTTTGCGTTTATTTATTTAAAAAATGTCTCAGAGCCTACTAAACCAAAGGTAGATGTGTTATCTATTC
TTTTATCTACAATTGGATTTGGCGGGATTGTTTATGGATTCAGTAGCTCAGGTGAAGGTTGGGATAGTTTCCAGGTGTAT
GGAATCATTCTAATTGGCCTTGTAGCACTTCTATTTTTCGTATTACGTCAATTGAAATTGAAAGAGCCATTACTAGACCT
TAGTGCATTTAAGTATCCGATGTTTACGCTAACGACAATTTTATTGACAATCATGATGATGACGATGTTCTCGACAATGA
CGTTACTACCATTTCTATTCCAAGGTGCTTTAGGCTTAACTGTCTATGCAACTGGTCTTATCATGCTTCCAGGTAGCCTG
TTAAATGGTCTGCTTTCTCCAGTTTCAGGGAAGCTTTTTGATAAATTTGGTCCAAGAGCGCTCATTATTCCTGGTACGAT
ATTATTAGCAGGTGTGATGTGGTTCTTTACACAAGTAACGGCAGATACGTCTAAAATAACTTTCATCCTATTACATGTCA
CTATGATGGTATCCATTTCAATGATTATGATGCCGGCGCAAACGAACGGTTTGAACCAACTTCCGAAGCGATTTTATCCT
CACGGAACAGCTATTTTGAATACTCTATCACAAGTAGCGGGTGCGGTAGGAGTTGCGTTCTTTATTAGCGTTATGACTTC
CGGACAGAAGAAATATTTGGATGCATCTTCAAATCCGACTGACCCAGCTCAATTGACAGAAGCAATGGTTTCAGGCGTGC
ATAACGCATTTACAATTGGCTTTGGTTTGGCACTACTTGCAGTTGTTGTAGCTTTGTTTATAAAACGTTCGCAGACTTCA
GAAAGTTAA

Upstream 100 bases:

>100_bases
GTTATGCTGTATCGTTTTCAATTTGGTACGGGCGTTTCTACGTTAAATATGACTAGCAAAGTTAATAAAAATTTATAAAA
GAATACAAGGAGGTTTATGT

Downstream 100 bases:

>100_bases
GGGGCGAAGTAAAGAGGGGATGCCGAGGGCTACCCTCTTTATTATTTTGTTCCTACATAGTAATTTGATTTGGGTTCCTT
CTTATTAAAATAGTATTTTT

Product: drug resistance transporter, EmrB/QacA family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNAQTAPVSSQSKEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLIMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLAGVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
ES

Sequences:

>Translated_482_residues
MNAQTAPVSSQSKEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLIMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLAGVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
ES
>Mature_482_residues
MNAQTAPVSSQSKEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLIMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLAGVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
ES

Specific function: Proton-dependent transporter. May mediate the efflux of lincomycin [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=409, Percent_Identity=25.1833740831296, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789042, Length=459, Percent_Identity=24.1830065359477, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788710, Length=420, Percent_Identity=25, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790195, Length=347, Percent_Identity=27.3775216138329, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788392, Length=394, Percent_Identity=27.4111675126904, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325455, Length=250, Percent_Identity=25.6, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52270; Mature: 52270

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQTAPVSSQSKEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
WLSTGYMLVVAVLIPASALLVQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AAGTGLIMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPAIGPTLSGIILETLNWRWLFY
HHCCCHHHHHHHHHHEEEECCCHHCCCCCCHHHHHEECCCCCCHHHHHHHHHCCHHHHHH
IVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALGLTVYATGLIMLPGSLLNGLLSPVSGKLFDKFGPRALIIPGTILLAGVMWFFTQVT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
ADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYPHGTAILNTLSQVAGAVGVAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
HHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ES
CC
>Mature Secondary Structure
MNAQTAPVSSQSKEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
WLSTGYMLVVAVLIPASALLVQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AAGTGLIMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPAIGPTLSGIILETLNWRWLFY
HHCCCHHHHHHHHHHEEEECCCHHCCCCCCHHHHHEECCCCCCHHHHHHHHHCCHHHHHH
IVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALGLTVYATGLIMLPGSLLNGLLSPVSGKLFDKFGPRALIIPGTILLAGVMWFFTQVT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
ADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYPHGTAILNTLSQVAGAVGVAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
HHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ES
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377 [H]