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The map label for this gene is kgtP [H]

Identifier: 218902121

GI number: 218902121

Start: 969755

End: 971080

Strand: Reverse

Name: kgtP [H]

Synonym: BCAH820_1003

Alternate gene names: 218902121

Gene position: 971080-969755 (Counterclockwise)

Preceding gene: 218902135

Following gene: 218902120

Centisome position: 18.31

GC content: 42.99

Gene sequence:

>1326_bases
ATGGCTCAAGCAAAATCTAATCGAGTCGCCGGCAATATTTTCAAAGGTTCTATCGGCAATTTAATCGAATGGTACGACTG
GTACGTTTACTCTGCTTTTGCTGTTTATTTTTCAGCGGAGTTCTTTCCTAAAGGCGATCCAACGAGTCAATTATTGAACA
CAGCAGCTATTTTCGCAGTTGGATTTTTAATGCGCCCTATCGGAAGTTTATTAATGGGACGTTATGCAGATCGGCACGGA
CGCCGGGCAGCATTAACGCTTTCGATTACGGTTATGGCCGGTGGTTCTTTAATTATCGCCTGTACACCTAGTTACGAAAG
CATCGGTATTATGGCACCTATTATTTTAGTTCTTGCTCGTTTACTACAAGGATTATCACTTGGCGGAGAGTACGGAACTT
CCGCAACATATTTATCTGAAATGGCTAGTAGTGGTCGCCGCGGTTTTTATTCAAGTTTCCAATATGTAACGCTCGTTGCG
GGGCAAATGGTTGCATTAGGCGTTCAAATTGTTCTTCAGCAATTACTAAGCGAACCAGATATGAAAGCTTGGGGATGGCG
TATTCCATTCATTATTGGAGCGATGGGCGCAGTAGCTGTATTATGGCTTCGCCGCACGATGGATGAATCGGAGCAGTTCG
CAAACGTAAAATCACAAAATCGCGAAAGCGCAGGAACCGTTCGCGCGCTTATGAAACATCCTAAAGCAGTATTAACAGTA
GTCGGCCTAACACTCGGAGGCACTGTCGCATTCTATACGTACACAACATATTTACAAAAGTTCATGGTAAACACAGTCGG
TCTTCCGAAAGAAGTTGTAAGCTGGATTAACTTTGTCGCACTACTTATTTTCGTCGTACTTCAACCAATTGCGGGGCTAT
TATCCGATAAAATTGGACGACGCCCACTATTAATGGCATTCGGTATTCTCGGAACGTTACTAACAGCACCAATCTTCTTC
TTTATGGAAAAAACGACAGAACCAATCGTAGCATTTTTACTTATGATGGTCGGCCTTATTATCGTTACTGGTTACACTTC
CATTAACGCAATTGTAAAAGCAGAGCTCTTCCCAACTGAAATTCGTGCACTTGGCGTAGGTTTACCATATGCACTAACCG
TTGCGATATTCGGCGGAACAGCTGAGTTCATCGCATTATGGCTAAAAAGTATCGGAATGGAATCACTATTCTACTTCTAC
GTAGCTGGATGTATCGCCATCAGCTTTATTACGTATTGGCGTATGGATGAATCATCGAAGACTTCGCAGATTGAGGCGGA
GCTTGGTGGTGGGGATAGTTTGAAGAATGGTACTAGTTTAAAATAA

Upstream 100 bases:

>100_bases
TCATAATATTGAGATTTCGTTCCGTAGACAGTACAATTCAAATACATTGAACGCGCTTTCATAATTATCATTTTATTTAT
AAGCAAGAGGAGGAATGATT

Downstream 100 bases:

>100_bases
TAAAGTGCGATTGGTCACCTTGAAAAGAGGTGGCCTTTTGTATACTTTTTCAAAGAATCTAACATCAAAAAACACTTTCC
ACTGCCAAATTAAAACCATC

Product: alpha-ketoglutarate permease

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAQAKSNRVAGNIFKGSIGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHG
RRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVA
GQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANVKSQNRESAGTVRALMKHPKAVLTV
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFF
FMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFY
VAGCIAISFITYWRMDESSKTSQIEAELGGGDSLKNGTSLK

Sequences:

>Translated_441_residues
MAQAKSNRVAGNIFKGSIGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHG
RRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVA
GQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANVKSQNRESAGTVRALMKHPKAVLTV
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFF
FMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFY
VAGCIAISFITYWRMDESSKTSQIEAELGGGDSLKNGTSLK
>Mature_440_residues
AQAKSNRVAGNIFKGSIGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGR
RAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAG
QMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANVKSQNRESAGTVRALMKHPKAVLTVV
GLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFF
MEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYV
AGCIAISFITYWRMDESSKTSQIEAELGGGDSLKNGTSLK

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=420, Percent_Identity=50.2380952380952, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1790550, Length=428, Percent_Identity=28.0373831775701, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788292, Length=427, Percent_Identity=29.5081967213115, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1789941, Length=404, Percent_Identity=34.1584158415842, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082231, Length=255, Percent_Identity=27.0588235294118, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082404, Length=326, Percent_Identity=24.8466257668712, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48029; Mature: 47898

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAKSNRVAGNIFKGSIGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLAR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHH
LLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPD
HHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANVKSQNRESAGTVRALMKHPKAVLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTE
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
IRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWRMDESSK
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSQIEAELGGGDSLKNGTSLK
CCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AQAKSNRVAGNIFKGSIGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GFLMRPIGSLLMGRYADRHGRRAALTLSITVMAGGSLIIACTPSYESIGIMAPIILVLAR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHH
LLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPD
HHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANVKSQNRESAGTVRALMKHPKAVLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEVVSWINFVALLIFVVLQPIAGLLSDKIGR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTE
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
IRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWRMDESSK
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSQIEAELGGGDSLKNGTSLK
CCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]