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The map label for this gene is sph [H]

Identifier: 218901872

GI number: 218901872

Start: 710101

End: 711102

Strand: Direct

Name: sph [H]

Synonym: BCAH820_0733

Alternate gene names: 218901872

Gene position: 710101-711102 (Clockwise)

Preceding gene: 218901871

Following gene: 218901873

Centisome position: 13.39

GC content: 36.03

Gene sequence:

>1002_bases
GTGAAAGGTAAATTGCTAAAAGGTGTACTTAGTTTTGGGATTGGTTTAGGAGTTTTATACGGAGGATCCTCAGCTCAAGC
AGATACGTCTACAAATCAAAACAATACTTTGAAAGTGATGACGCATAACGTGTACATGCTATCAACTAACTTATATCCGA
ATTGGGGACAAAGTGAGCGTGCTGATTTAATTGGGGCGGCAGATTATATTAAGAATCAAGACGTTGTTATATTAAATGAA
GTGTTTGATAATAGTGCTTCAGATCGCCTTTTAGGAAATTTGAAGAAAGAATACCCAAATCAAACAGCTGTATTAGGTCG
TAGCAACGGAAATGAATGGGATAAAACGTTAGGTAGCTATTCATCTGCAACTCCTGAAGATGGAGGCGTTGCAATCGTTA
GCAAATGGCCGATCGTTGAAAAGGTTCAATATGTATTTGCAAATGGATGTGGACCAGATAATTTATCGAATAAAGGATTT
GTATACACGAAAATTAAGAAAAATGATCGTTTCGTTCATGTAATTGGGACGCATTTGCAGGCTGAAGATAGTATGTGCGG
AAAAACTTCACCTGCATCTGTACGTACAAACCAGTTAAAAGAAATTCAAGATTTTATTAAAAATAAAAATATACCAAATG
ACGAGTACGTCCTATTTGGTGGTGATATGAATGTGAATAAAATAAATGCTGAGAACAATAGTGACTCAGAATACGCATCA
ATGTTCAAAACATTGCACGCTTCTATTCCATCTTATACAGGACATACAGCAACTTGGGATGCAACGACAAACAGTATTGC
AAAATATAATTTCCCTGATAGCCCTGCCGAGTATTTAGATTATATTATTGCAAGTAAGGACCATGCGAATCCGTCATTTA
TAGAGAATAAAGTATTACAACCGAAATCTCCACAGTGGACTGTTACATCATGGCTCAAAAAATATACATATAATGATTAC
TCTGATCATTATCCTGTCGAGGCGACTATTTCTATGAAGTAG

Upstream 100 bases:

>100_bases
TGGTTTGATACGTACGGAGATCGTTAAGGATTTAAAAAAGGTCAAATCTCACAATAGAGTATTTGACCTTTTTATTACTA
TACACATGGAGGTATGGAAC

Downstream 100 bases:

>100_bases
TCTTAAAAAGTTTCTTCTTAATAGGAAGAAACTTTTTTATTTTGTAGAGGAAATTTCAACTTTCTTTCCAATATGTATAA
GACATATTGAAAAGAGGAGA

Product: sphingomyelin phosphodiesterase C

Products: NA

Alternate protein names: SMase; Cereolysin B; SMPLC; Sphingomyelin phosphodiesterase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKGKLLKGVLSFGIGLGVLYGGSSAQADTSTNQNNTLKVMTHNVYMLSTNLYPNWGQSERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSATPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYAS
MFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQPKSPQWTVTSWLKKYTYNDY
SDHYPVEATISMK

Sequences:

>Translated_333_residues
MKGKLLKGVLSFGIGLGVLYGGSSAQADTSTNQNNTLKVMTHNVYMLSTNLYPNWGQSERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSATPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYAS
MFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQPKSPQWTVTSWLKKYTYNDY
SDHYPVEATISMK
>Mature_333_residues
MKGKLLKGVLSFGIGLGVLYGGSSAQADTSTNQNNTLKVMTHNVYMLSTNLYPNWGQSERADLIGAADYIKNQDVVILNE
VFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSATPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGF
VYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYAS
MFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQPKSPQWTVTSWLKKYTYNDY
SDHYPVEATISMK

Specific function: Required, with sphingomyelinase, to effect target cell lysis (hemolysis) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 36935; Mature: 36935

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKLLKGVLSFGIGLGVLYGGSSAQADTSTNQNNTLKVMTHNVYMLSTNLYPNWGQSER
CCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCH
ADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSY
HHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
SSATPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQ
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEE
AEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYAS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCCCHHHHH
MFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQ
HHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCC
PKSPQWTVTSWLKKYTYNDYSDHYPVEATISMK
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKGKLLKGVLSFGIGLGVLYGGSSAQADTSTNQNNTLKVMTHNVYMLSTNLYPNWGQSER
CCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCH
ADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSY
HHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
SSATPEDGGVAIVSKWPIVEKVQYVFANGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQ
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEE
AEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYAS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCCCHHHHH
MFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQ
HHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCC
PKSPQWTVTSWLKKYTYNDYSDHYPVEATISMK
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2848222; 8387306; 3137122 [H]