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The map label for this gene is capL [H]

Identifier: 218901645

GI number: 218901645

Start: 475672

End: 476913

Strand: Direct

Name: capL [H]

Synonym: BCAH820_0487

Alternate gene names: 218901645

Gene position: 475672-476913 (Clockwise)

Preceding gene: 218901644

Following gene: 218901646

Centisome position: 8.97

GC content: 35.1

Gene sequence:

>1242_bases
ATGAATAGTAGTAAAGTAGCTATTATTGGCTTAGGGTATGTTGGCCTTCCTTTAGCAGTCCATTTTGCAGAGAGAGGGCA
TACAGTACTTGGGTTAGATAAAGATATTAGAAAAATAGAATCAATTATAAAAGGAGAAAGTTATATTCCGGACGTTTCTT
CTAAAGAGTTACAAAGTTTATTGATGAAAAAAAAATTAATAGTGAACACACCGGATCAAGGCATTGCTGATTTTCAAAAT
AGTGATTATGTTATTGTTACTGTCCCGACTCCAATTAATGAACAAAGAGAACCAGACTTAAGTGCCCTCATTTCAGCCTC
ACATTATATACAACAAAACCTTCAAAAAGGACAAACCTTCATTTTTGAAAGCTCCACATATCCAGGTACACTCGAGGAAG
TTATTATTCCTATTATTTCTCAAACAGGTAAAAAGGCAGGAGAAGATTTCTATATCGGATATTCCCCTGAGAGAATTGAT
CCAGCAAATAGTCAATATTCAGTTCAAACGATTCCAAAAGTTATTAGTGGACAAACAGAAAAGTGTAAACAAAAAGTACA
GGCTTTGTATAGCACTATTTTTGATGTAGTTGTTCCAGTTAGTTCTCCGAAAGTAGCGGAGATGTGTAAGCTATTCGAAA
ACATTCAGCGCCTAGTTAATATTTCGTTAGTCAATGAGCTAAACACACTATGTGAAAGTTTAGGAATTGATTTTTATGAG
GCGCTTGAAGCGGCATCTACAAAACCATTTGGATTTACTCCATATTGGCCAGGTCCAGGGATAGGAGGACACTGTATTCC
AGTAGACCCTTTATATTTTCAATGGAGAATAAAAAAGAATGGTGCAATAAGTCAATTGATTGAAGCAGCGCATGTAATTA
ATGAAGAAATGCCAGAGAAAATGGTCCAGAAAGTAAAAGGTGTGGTGCAACCACCTGCAACGGTTTTAATTGTAGGGATT
GCATATAAGAAAGATGTAAATGACTTAAGAGAATCACCAGCGTTGCCAATTATTGAATTGTTAATAAAAGAAGGATACGA
GATAGAATATCACGATCCATATATTTCTTCGGCAAAATTTGGAGATAAGGTGTACCAATCTGTTTCTTTAAATGAACAAG
CCGTTAACCAAGCGAGTTGTATTTTAATTTTAACGGATCATTCTAATATTGATTGGAAGCTTTTTAAAGGAATAAAGCGA
GTAGTAGATACACGTGGGATTGTAAAGAAGGTGAGTAAATGA

Upstream 100 bases:

>100_bases
GCGTATTTATTACAATGTACGGACGAACGCGGTGGCTTTACGGATGGAGATAGAGATAGAGATATCATTCAACAATTGAG
AAGGGAAGAAGAGAATACAA

Downstream 100 bases:

>100_bases
GTAAGAAATGTTTAATTACAGGCGGAGCAGGATTTATTGGATCCCATTTAGCTGAAGAGTTGGTGGGAAGAGGTTATAAT
GTCACGATTGTTGATAACTT

Product: putative polysaccharide biosynthesis protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIESIIKGESYIPDVSSKELQSLLMKKKLIVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERID
PANSQYSVQTIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
ALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVGI
AYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKR
VVDTRGIVKKVSK

Sequences:

>Translated_413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIESIIKGESYIPDVSSKELQSLLMKKKLIVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERID
PANSQYSVQTIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
ALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVGI
AYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKR
VVDTRGIVKKVSK
>Mature_413_residues
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIESIIKGESYIPDVSSKELQSLLMKKKLIVNTPDQGIADFQN
SDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTFIFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERID
PANSQYSVQTIPKVISGQTEKCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
ALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVGI
AYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKR
VVDTRGIVKKVSK

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=428, Percent_Identity=23.5981308411215, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994968, Length=435, Percent_Identity=30.8045977011494, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=21.2121212121212, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=394, Percent_Identity=24.6192893401015, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17136908, Length=397, Percent_Identity=23.9294710327456, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45842; Mature: 45842

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIESIIKGESYIPDVSSKELQSL
CCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LMKKKLIVNTPDQGIADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTF
HHHHHHEECCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
IFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERIDPANSQYSVQTIPKVISGQTE
EEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHH
KCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHVINEEMPEK
HHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKF
HHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHH
GDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKRVVDTRGIVKKVSK
HHHHHHHHCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSSKVAIIGLGYVGLPLAVHFAERGHTVLGLDKDIRKIESIIKGESYIPDVSSKELQSL
CCCCCEEEEEECHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LMKKKLIVNTPDQGIADFQNSDYVIVTVPTPINEQREPDLSALISASHYIQQNLQKGQTF
HHHHHHEECCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
IFESSTYPGTLEEVIIPIISQTGKKAGEDFYIGYSPERIDPANSQYSVQTIPKVISGQTE
EEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHH
KCKQKVQALYSTIFDVVVPVSSPKVAEMCKLFENIQRLVNISLVNELNTLCESLGIDFYE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAISQLIEAAHVINEEMPEK
HHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKF
HHHHHHHCCCCCCEEEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHH
GDKVYQSVSLNEQAVNQASCILILTDHSNIDWKLFKGIKRVVDTRGIVKKVSK
HHHHHHHHCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]