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The map label for this gene is fumA [H]

Identifier: 218901627

GI number: 218901627

Start: 459548

End: 461068

Strand: Direct

Name: fumA [H]

Synonym: BCAH820_0469

Alternate gene names: 218901627

Gene position: 459548-461068 (Clockwise)

Preceding gene: 218901626

Following gene: 218901628

Centisome position: 8.67

GC content: 39.64

Gene sequence:

>1521_bases
ATGGAAAAGCTTCAAGAAAGCATGTATCAACTAATTGTTGAAACGTCAACGAACTTACCGAAAGATGTTCGTCGTGCGAT
TCAACAAGCGAAAGAGCGAGAAAATGCAGGGACTCGCTCTGCAATGGCACTTGGCACAATTACAAATAATATTAAAATGG
CTGATGATAACATCTCACCAATTTGCCAAGATACAGGGATGCCAACGTTTAAAATTTATACACCAGTTGGTGTGAATCAA
TTAAAGTTGAAGGAAGCTATCTATCATGCGCTTGAGCGGGCGACAAAAGATGGTAAACTTCGTCCAAATTCTGTTGATTC
TCTTTTTGGAGACAATAGTGGAAATAATTTAGGACCAGGTACACCGGTGATTAAGTTTGAACAATGGGAAAAAGATTATA
TTGATGCACGTTTAATTCTAAAGGGTGGTGGCTGTGAGAATAAAAATATTCAGTATAGCTTACCATGTGAATTAGAAGGA
CTTGGACGCGCAGGCCGTGATTTAGAAGGGATTCGTAAATGCCTTCTTCATGCAGTGTATCAAGCGCAAGGTCAAGGATG
TAGTGCAGGTGTAATTGGTGTTGGTATCGGGGGAGACCGCACATCAGGTTACGAATTAGCAAAAAATCAATTATTCCGTA
CATTAGATGATGTTAATCCAATTCCAGAATTACAACAACTTGAAGAATATGTCTTAGAAAATGCGAATAAGCTTGGCATT
GGTACGATGGGATTTGGCGGAGAAACAACTTTACTTGGCTGTAAAATTGGCGTGTATAATCGTCTGCCGGCTAGCTTCTA
CGTATCTGTGGCGTATAATTGCTGGGCATATCGCCGCCTTGGCGTAACAATTCACCCTGAAACAGGTGAAATTATGGATT
GGTTATATCAAGAAGGTGACGATACACTTCAGCAAGAAGCGCAAGAAAAAACAGAGCAACGTGAGATTGTATTACAAGCA
CCAATTACAGAAGAGCAAATTCGTGAACTTCGCGTTGGTGATGTTGTAACAATTAATGGCATGATGTATACAGGTCGTGA
CGCAATCCATAAGCATTTAATGGATAACGATTGTCCAGTAGATTTAAATGGACAAGTTATTTATCACTGTGGTCCAGTTG
TCGTGAAAGATGAAAATGACAATTGGCAAATTAAAGCGGCAGGTCCAACGACAAGTATTCGTGAAGAACCGTACCAAGGC
GATATTATGAAGAAATTCGGTATTCGCGCTGTCATTGGAAAAGGTGGTATGGGTGCGAAAACTTTAGCGTCTTTAGAAGA
ACACGGCGGTGTATATTTAAACGCAATCGGTGGTGCAGCGCAATATTATGCTGAATGTATTAAAGAAGTGAAAGATGTTG
ATTTCTTACAATTTGGTATTCCAGAGGCAATGTGGCACTTACGTATTGAAGGGTTTAAAGCAGTTGTAACGATGGATTCT
CATGGTAATAGCTTACATGCAGATGTTGATAAAACATCACTTGAAAAATTAGCGAGCTTTAAAGAGCCAGTATTTAAGTA
A

Upstream 100 bases:

>100_bases
GCTTGAATAGCGTGAAACAAATAAAAAGCGAAAGAACATAACGATGGAATTTTTAGCTCATAACGTTTTGGTAGCGTTCA
CAATTGAGGGGGAAGTAACA

Downstream 100 bases:

>100_bases
ACAAAAATGCATCTCGAATGATTCGAGATGCATTTTTTTGGTATATATAGAAAAACATGTTCAGCATGAAAGAATGTGCG
GCAACAAAAACTACAAGTAC

Product: fumarate hydratase, class I

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYHALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPIPELQQLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMDWLYQEGDDTLQQEAQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLASLEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIEGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK

Sequences:

>Translated_506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYHALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPIPELQQLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMDWLYQEGDDTLQQEAQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLASLEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIEGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK
>Mature_506_residues
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISPICQDTGMPTFKIYTPVGVNQ
LKLKEAIYHALERATKDGKLRPNSVDSLFGDNSGNNLGPGTPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEG
LGRAGRDLEGIRKCLLHAVYQAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPIPELQQLEEYVLENANKLGI
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMDWLYQEGDDTLQQEAQEKTEQREIVLQA
PITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPVDLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQG
DIMKKFGIRAVIGKGGMGAKTLASLEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIEGFKAVVTMDS
HGNSLHADVDKTSLEKLASFKEPVFK

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=183, Percent_Identity=34.9726775956284, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789442, Length=289, Percent_Identity=27.681660899654, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790564, Length=467, Percent_Identity=24.6252676659529, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1787897, Length=475, Percent_Identity=24.8421052631579, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 55932; Mature: 55932

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEECCEEECCCCCCC
ICQDTGMPTFKIYTPVGVNQLKLKEAIYHALERATKDGKLRPNSVDSLFGDNSGNNLGPG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCC
TPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVY
CCEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPIPELQQLEEYVLENANKLGI
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCE
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMDWLYQEGD
EEECCCCCCEEEEEEECCCCCCCHHEEEEEHHCCEEEEEECEEECCCCCHHHHHHHHCCC
DTLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPV
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCEEECCHHHHHHHHCCCCCCC
DLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAK
CCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCHH
TLASLEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIEGFKAVVTMDS
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHEEEECEEEEEEECC
HGNSLHADVDKTSLEKLASFKEPVFK
CCCEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKLQESMYQLIVETSTNLPKDVRRAIQQAKERENAGTRSAMALGTITNNIKMADDNISP
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEEECCEEECCCCCCC
ICQDTGMPTFKIYTPVGVNQLKLKEAIYHALERATKDGKLRPNSVDSLFGDNSGNNLGPG
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCC
TPVIKFEQWEKDYIDARLILKGGGCENKNIQYSLPCELEGLGRAGRDLEGIRKCLLHAVY
CCEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QAQGQGCSAGVIGVGIGGDRTSGYELAKNQLFRTLDDVNPIPELQQLEEYVLENANKLGI
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCE
GTMGFGGETTLLGCKIGVYNRLPASFYVSVAYNCWAYRRLGVTIHPETGEIMDWLYQEGD
EEECCCCCCEEEEEEECCCCCCCHHEEEEEHHCCEEEEEECEEECCCCCHHHHHHHHCCC
DTLQQEAQEKTEQREIVLQAPITEEQIRELRVGDVVTINGMMYTGRDAIHKHLMDNDCPV
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCEEEECCEEECCHHHHHHHHCCCCCCC
DLNGQVIYHCGPVVVKDENDNWQIKAAGPTTSIREEPYQGDIMKKFGIRAVIGKGGMGAK
CCCCEEEEEECCEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCHH
TLASLEEHGGVYLNAIGGAAQYYAECIKEVKDVDFLQFGIPEAMWHLRIEGFKAVVTMDS
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHEEEECEEEEEEECC
HGNSLHADVDKTSLEKLASFKEPVFK
CCCEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]