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The map label for this gene is gyrA [H]

Identifier: 218901212

GI number: 218901212

Start: 6596

End: 9067

Strand: Direct

Name: gyrA [H]

Synonym: BCAH820_0006

Alternate gene names: 218901212

Gene position: 6596-9067 (Clockwise)

Preceding gene: 218901211

Following gene: 218901214

Centisome position: 0.12

GC content: 36.61

Gene sequence:

>2472_bases
ATGTCAGACAATCAACAACAAGCACGAATTCGAGAAATTAATATTAGCCATGAAATGCGTACCTCATTTTTAGATTACGC
AATGAGTGTTATCGTATCTCGTGCATTACCAGATGTTCGTGATGGATTAAAACCTGTGCATCGTAGGGTTTTATATGCGA
TGAATGATTTAGGAATTACGGCTGATAAAGCGTATAAAAAATCAGCACGTATTGTTGGTGAAGTAATCGGTAAGTATCAC
CCTCATGGTGATTCAGCTGTTTATGAAACGATGGTACGTATGGCGCAAGATTTCAGTCAACGTTATATGCTTGTTGATGG
GCATGGTAACTTTGGATCTGTCGATGGAGATTCAGCGGCAGCAATGCGTTATACAGAAGCAAGAATGTCTAAAATCTCTA
TGGAATTAATACGTGATATTTCAAAAAATACAATTGATTATCAAGATAACTATGATGGTTCTGAAAGAGAGCCGATTGTG
TTACCAGCGCGTTTTCCTAACTTACTAGTAAATGGTACGACAGGTATTGCAGTTGGTATGGCAACAAATATTCCGCCGCA
TCAACTTGGTGAAGTAATTGATGGCGTATTGGCATTAAGTCATAATCCCGATATTACTATTGCAGAATTAATGGAGTGCA
TTCCAGGACCAGATTTCCCGACGGCAGGTTTAATTTTAGGAAGAAGTGGTATTCGTAGAGCTTATGAAACAGGACGCGGG
TCTATTATACTTCGTGCTAAAGTTGAAATTGAAGAGAAGTCAAATGGCAAACAATCTATTATCGTAACGGAACTACCTTA
TCAAGTGAATAAGGCGCGATTGATTGAAAAAATTGCAGAATTAGTTCGCGATAAGAAAATTGAAGGTATTACAGATTTAC
GTGATGAATCAGATCGAAATGGTATGCGTATTGTTATGGAAGTACGTCGTGATGCCAATGCTAATGTATTATTAAATAAC
TTATATAAACATACAGCACTTCAAACAAGTTTTGGTATTAACATGCTGTCTCTTGTAAATGGAGAACCACAAGTACTGAA
TTTAAAACAAAATTTATATCATTACTTGGAACATCAAAAGGTAGTAATTCGTAGACGTACTGCTTATGAACTTGAAAAGG
CAGAAGCACGTGCTCATATCTTAGAAGGATTACGAATTGCTTTAGACCATCTGGATGAAGTTATTACATTAATTCGTAAT
TCGAAAACAGCGGAAATTGCAAAGCAAGGTTTAATGGAACGTTTTGGCTTAAGTGAAAAACAAGCGCAAGCTATTTTAGA
TATGCGTCTGCAACGCTTAACAGGATTAGAACGCGAAAAAATTGAACAAGAATATCAAGATTTAATGAAGTTAATCGCTG
AATTAAAAGCAATCTTAGCAGATGAAGAAAAGGTTCTTGAGATTATTCGTGAAGAATTAACAGAAGTAAAAGAGCGCTTC
AATGATAAGAGACGTACAGAAATTACAATTGGTGGTATGGAGTCTATTGAAGATGAAGACTTGATTCCAGAACAAAACAT
CGCCATTACGTTAACTCATAATGGTTATATTAAGAGGTTGCCAGCTTCTACGTACAAAACACAGAACCGTGGTGGACGTG
GTGTGCAGGGAATGGGAACAAATGATGATGATTTCGTAGAGCATTTATTAACCACTTCTACGCATGATCATATTCTATTC
TTCACTAATAAGGGGAAAGTATACCGTACGAAAGGATATGAAATCCCAGAGTATAGTCGTACAGCGAAAGGTATACCTAT
TATTAACTTATTAGGTGTAGATAAGGGTGAATGGATTAACGCCATTATTCCAATTCGTGAATTTGGTGACGATGAATTCT
TATTCTTCACAACAAAACAAGGTATCTCTAAGAGAACACCACTTTCATCATTTGCGAATATACGTACAAATGGTTTAATT
GCAATTTCTCTTCGTGAAGAGGATGAAGTAATATCTGTACGTTTAACATCTGGTGATAAGGATATTATTGTAGGTACAAG
CAATGGTATGCTAATTCGTTTTAACGAGCAAGATGTACGTTCTATGGGACGTAATGCGGCTGGTGTAAAAGCAATTACAT
TAGGTGAAGAAGATCAAGTTGTAGGTATGGAAATTGTCGAAGAGGATGTAAATGTTTTAATTGTAACGAAAAATGGTTAT
GGAAAACGTACGCCGATTGATGAATATCGCTTGCAAAGCCGTGGTGGTAAAGGTCTGAAGACTTGTAATATTACAGATAA
AAACGGTAAGTTAGTAGCTGTTAAATCTGTAACAGGTGAAGAAGATATCATGTTAATTACAGCAGCAGGTGTTATTATTC
GTATGCCAGTTGATCAAATCTCTCAAATGGGACGTAATACACAAGGTGTTCGTCTAATTCGATTAGAGGATGAGCAAGAG
GTAGCGACAGTAGCAAAAGCACAAAAAGATGATGAGGAAGAAACGAGCGAAGAGGTTTCTTCAGAAGAATAA

Upstream 100 bases:

>100_bases
CTTGATATTTAAATGAGTAATGACAGGAATCTGAGTATTCCTGTCTTCTACATATAAATCAATGTATGTGTAACGGAAAT
GTAAGAGGAGGTGCTCGTTG

Downstream 100 bases:

>100_bases
GAGAGGAGATATCTCCTCTCTTTATTTTTTTATAATAATACTTGCATGGGGAAGAGAAAGTCTATATAATAGGCAGAGTC
AGCAAATGAGAGATACAAGT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYH
PHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIV
LPARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRG
SIILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLNN
LYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRN
SKTAEIAKQGLMERFGLSEKQAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERF
NDKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILF
FTNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWINAIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLI
AISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGY
GKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQISQMGRNTQGVRLIRLEDEQE
VATVAKAQKDDEEETSEEVSSEE

Sequences:

>Translated_823_residues
MSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYH
PHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIV
LPARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRG
SIILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLNN
LYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRN
SKTAEIAKQGLMERFGLSEKQAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERF
NDKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILF
FTNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWINAIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLI
AISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGY
GKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQISQMGRNTQGVRLIRLEDEQE
VATVAKAQKDDEEETSEEVSSEE
>Mature_822_residues
SDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYHP
HGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVL
PARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRGS
IILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLNNL
YKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRNS
KTAEIAKQGLMERFGLSEKQAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERFN
DKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILFF
TNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWINAIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLIA
ISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGYG
KRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQISQMGRNTQGVRLIRLEDEQEV
ATVAKAQKDDEEETSEEVSSEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.7861635220126, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913406, Length=317, Percent_Identity=25.2365930599369, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788562, Length=850, Percent_Identity=52.9411764705882, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=695, Percent_Identity=37.2661870503597, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17535065, Length=212, Percent_Identity=30.6603773584906, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=204, Percent_Identity=29.9019607843137, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=200, Percent_Identity=28, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92366; Mature: 92235

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGIT
CCCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
AMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVLPARFPNLLVNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEE
ATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRG
ECCCCHHHHHHHHHHHHEECCCCCEEHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCC
SIILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRN
CEEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCC
GMRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQK
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHH
VVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRNSKTAEIAKQGLMERFGLSEK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
QAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NDKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGT
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCC
NDDDFVEHLLTTSTHDHILFFTNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWIN
CHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCEE
AIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLIAISLREEDEVISVRLTSGDK
EEEEHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC
DIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGY
EEEEECCCCEEEEECHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHCCCCCEEEEEECCC
GKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQI
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEECCHHHH
SQMGRNTQGVRLIRLEDEQEVATVAKAQKDDEEETSEEVSSEE
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGIT
CCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
AMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVLPARFPNLLVNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEE
ATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRG
ECCCCHHHHHHHHHHHHEECCCCCEEHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCC
SIILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRN
CEEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCC
GMRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQK
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHH
VVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRNSKTAEIAKQGLMERFGLSEK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
QAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NDKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGT
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCC
NDDDFVEHLLTTSTHDHILFFTNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWIN
CHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCEE
AIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLIAISLREEDEVISVRLTSGDK
EEEEHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC
DIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGY
EEEEECCCCEEEEECHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHCCCCCEEEEEECCC
GKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQI
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEECCHHHH
SQMGRNTQGVRLIRLEDEQEVATVAKAQKDDEEETSEEVSSEE
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]