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The map label for this gene is glmS [H]

Identifier: 218884709

GI number: 218884709

Start: 1300347

End: 1302185

Strand: Reverse

Name: glmS [H]

Synonym: DKAM_1398

Alternate gene names: 218884709

Gene position: 1302185-1300347 (Counterclockwise)

Preceding gene: 218884712

Following gene: 218884706

Centisome position: 95.38

GC content: 46.22

Gene sequence:

>1839_bases
TTGTGCGGAATAATAGGTTTATGCCTACACGATAAGAATACTTTAAGGCTAGGGGAGGCCATATACAGGGGTCTTCTTAG
GCTTGAGTACCGTGGATACGACTCGGCAGGCATAGCTGTAATCAGTGATAACGGGCTCATTATTTTAAAGGGCAAGGGTA
AACTGAACGAGCTTGAAGGCAAGTATTCTTTCACAAGCCTTGAAGGTATAACCGGGATAGGTCATACCAGGTGGGCCACA
CATGGTGCTCCAAACGATGTAAACGCGCATCCCCACACTGATTGCAACAACATGTTTGCGATAGTACATAATGGCGTCAT
AGAGAACTATATGGAGTTGAAAAAGATCCTTGCCTTAAAGGGGCATGTCTTCAAGAGTGAAACAGATACAGAGATAGTGG
CACACCTGATTGAGGAATATTATAAGGAGACGGGGAGTGTTTACCAAGCCTTTAAGAAGGCTATATCATCACTGAGAGGT
ACATACGCGATCCTCCTGATTACACCACTTGAACCCCATAAGATATTCTACGCTAGAAAGGATAGTCCTCTGGTAATAGG
GGTGGGCAACGGATACAATGCCGTGGCAAGCGATATACCAGCCCTGCTAGAGCACACGAGGAGAGTAATAGTCATAAGGG
ATGGATGGATCGGCTACATTACTCCATCAGAGATACATATCGAGGAACTAGATACGGGCCGCATACTCGAGTCAAGCAGG
TATATCAGGGTGGTTGAATGGGATCTAAAAGACGCCGAGAAGGAGGGATACCCATTCTTCATGATTAAAGAGATATATGA
GCAGCCAAGGGCCCTTAGAAGCACTATCCATGGATTAGTAAATGATGTAATAATTGATGAAGCAGTTAAGCTACTAGCTG
ATGCCGACAAGGTATTTATAACTGGAGCTGGCACGAGTTACCATGCCTCAGAATACTTCGCGTTAACAACGATGAAGCTA
TCTGGGAAACCAGTTATACCCTTCATAGCCAGCGAGTATGAGGTATATGCTGGGGTAGTTGGTTCCAGCGACATACTCAT
AGCTGTCAGCCAGAGCGGGGAGACAATGGATACTATGAAGGCTGTGAGAGCCTTCAAGGCGAAGGGGTGTAGAATCATTA
GCTTAACAAATGTAGTCGACTCAGCCATAGCTAGGGAAAGCGATATAGCTCTCTACACTAGGGCCGGGCCAGAGATAGGG
GTAGCTGCCACCAAGACCTTCCTAACTCAAACCCTATTCCTCTCATGGATATCCATTCTATTAGCCGGTGAGACAGGTAG
ATTAAACAGTAATGAAGCAGCCAAGCTACTGGAGGAGCTGAGAAATGCACCTAGATATGTTGAGGAATCATTATCGATGA
GTAGTGAAACCGTGAAGAAGCTAGCTGAGAAACTGGTCCCAGTTAAAAGCATGTACTATCTCAGCAGGGATATCGGGCTA
CCGGTTGCCAGAGAGGGAGCCCTCAAGATAAAGGAGATCGCATATATACATGCTGAAGCGTATCCAGCCGGCGAATCCAA
GCATGGTCCCATAGCATTGGTGGAGCCTTCATTCCCAGTAGTATTCACAGTACCAAGTGATAGAAAGCTTGAGAAACTAT
TATTGGGGAACATAGAGGAGATGAAGGCTAGAGGCGGATTCGTAATCAGTGTTGCTCCACAGGGATTCAACTTAAATGAG
AGAGCAGACATAGTGATAGAAGTCCCAAGGACGCATTGGATACTGACGTCTCTAACCCATACACCACCGCTTCAACTACT
CGCATACTATGTCGCCACGATGAAGGGCCTTGACCCGGATAAGCCGAGAAACCTGGCTAAAACCGTTACAGTGGAATAG

Upstream 100 bases:

>100_bases
ACCCGTTATCTTTAGGACAAGCACATCTCTCATCTTCACCACCGTCTTTTTTAAACATGCCCTGATATTTTAATATCGTA
CCTTGGGAGGATAGTTGGGT

Downstream 100 bases:

>100_bases
CTCTTAAGTCATCATCGATTCCTCAACGATCTCGATGACTTTACCCTCAAGCATTATCAATAGCCTTCAGCTTCTCTATG
TTCTCTACCTCAGATGAATC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIIGLCLHDKNTLRLGEAIYRGLLRLEYRGYDSAGIAVISDNGLIILKGKGKLNELEGKYSFTSLEGITGIGHTRWAT
HGAPNDVNAHPHTDCNNMFAIVHNGVIENYMELKKILALKGHVFKSETDTEIVAHLIEEYYKETGSVYQAFKKAISSLRG
TYAILLITPLEPHKIFYARKDSPLVIGVGNGYNAVASDIPALLEHTRRVIVIRDGWIGYITPSEIHIEELDTGRILESSR
YIRVVEWDLKDAEKEGYPFFMIKEIYEQPRALRSTIHGLVNDVIIDEAVKLLADADKVFITGAGTSYHASEYFALTTMKL
SGKPVIPFIASEYEVYAGVVGSSDILIAVSQSGETMDTMKAVRAFKAKGCRIISLTNVVDSAIARESDIALYTRAGPEIG
VAATKTFLTQTLFLSWISILLAGETGRLNSNEAAKLLEELRNAPRYVEESLSMSSETVKKLAEKLVPVKSMYYLSRDIGL
PVAREGALKIKEIAYIHAEAYPAGESKHGPIALVEPSFPVVFTVPSDRKLEKLLLGNIEEMKARGGFVISVAPQGFNLNE
RADIVIEVPRTHWILTSLTHTPPLQLLAYYVATMKGLDPDKPRNLAKTVTVE

Sequences:

>Translated_612_residues
MCGIIGLCLHDKNTLRLGEAIYRGLLRLEYRGYDSAGIAVISDNGLIILKGKGKLNELEGKYSFTSLEGITGIGHTRWAT
HGAPNDVNAHPHTDCNNMFAIVHNGVIENYMELKKILALKGHVFKSETDTEIVAHLIEEYYKETGSVYQAFKKAISSLRG
TYAILLITPLEPHKIFYARKDSPLVIGVGNGYNAVASDIPALLEHTRRVIVIRDGWIGYITPSEIHIEELDTGRILESSR
YIRVVEWDLKDAEKEGYPFFMIKEIYEQPRALRSTIHGLVNDVIIDEAVKLLADADKVFITGAGTSYHASEYFALTTMKL
SGKPVIPFIASEYEVYAGVVGSSDILIAVSQSGETMDTMKAVRAFKAKGCRIISLTNVVDSAIARESDIALYTRAGPEIG
VAATKTFLTQTLFLSWISILLAGETGRLNSNEAAKLLEELRNAPRYVEESLSMSSETVKKLAEKLVPVKSMYYLSRDIGL
PVAREGALKIKEIAYIHAEAYPAGESKHGPIALVEPSFPVVFTVPSDRKLEKLLLGNIEEMKARGGFVISVAPQGFNLNE
RADIVIEVPRTHWILTSLTHTPPLQLLAYYVATMKGLDPDKPRNLAKTVTVE
>Mature_612_residues
MCGIIGLCLHDKNTLRLGEAIYRGLLRLEYRGYDSAGIAVISDNGLIILKGKGKLNELEGKYSFTSLEGITGIGHTRWAT
HGAPNDVNAHPHTDCNNMFAIVHNGVIENYMELKKILALKGHVFKSETDTEIVAHLIEEYYKETGSVYQAFKKAISSLRG
TYAILLITPLEPHKIFYARKDSPLVIGVGNGYNAVASDIPALLEHTRRVIVIRDGWIGYITPSEIHIEELDTGRILESSR
YIRVVEWDLKDAEKEGYPFFMIKEIYEQPRALRSTIHGLVNDVIIDEAVKLLADADKVFITGAGTSYHASEYFALTTMKL
SGKPVIPFIASEYEVYAGVVGSSDILIAVSQSGETMDTMKAVRAFKAKGCRIISLTNVVDSAIARESDIALYTRAGPEIG
VAATKTFLTQTLFLSWISILLAGETGRLNSNEAAKLLEELRNAPRYVEESLSMSSETVKKLAEKLVPVKSMYYLSRDIGL
PVAREGALKIKEIAYIHAEAYPAGESKHGPIALVEPSFPVVFTVPSDRKLEKLLLGNIEEMKARGGFVISVAPQGFNLNE
RADIVIEVPRTHWILTSLTHTPPLQLLAYYVATMKGLDPDKPRNLAKTVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=33.5766423357664, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=33.1386861313869, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1790167, Length=625, Percent_Identity=41.28, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788651, Length=204, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082251, Length=369, Percent_Identity=22.7642276422764, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=32.7146171693735, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=32.5581395348837, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=32.5581395348837, Blast_Score=225, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6322745, Length=431, Percent_Identity=33.4106728538283, Blast_Score=213, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=26.8691588785047, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=39.5121951219512, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=32.0289855072464, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24659598, Length=259, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573187, Length=265, Percent_Identity=27.1698113207547, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24659604, Length=238, Percent_Identity=27.7310924369748, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67568; Mature: 67568

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGLCLHDKNTLRLGEAIYRGLLRLEYRGYDSAGIAVISDNGLIILKGKGKLNELEG
CCCEEEEEEECCCHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCC
KYSFTSLEGITGIGHTRWATHGAPNDVNAHPHTDCNNMFAIVHNGVIENYMELKKILALK
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GHVFKSETDTEIVAHLIEEYYKETGSVYQAFKKAISSLRGTYAILLITPLEPHKIFYARK
CCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEC
DSPLVIGVGNGYNAVASDIPALLEHTRRVIVIRDGWIGYITPSEIHIEELDTGRILESSR
CCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEECCCEEEEEECCCCCEECCCC
YIRVVEWDLKDAEKEGYPFFMIKEIYEQPRALRSTIHGLVNDVIIDEAVKLLADADKVFI
EEEEEEECCCCCCCCCCCEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TGAGTSYHASEYFALTTMKLSGKPVIPFIASEYEVYAGVVGSSDILIAVSQSGETMDTMK
EECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHH
AVRAFKAKGCRIISLTNVVDSAIARESDIALYTRAGPEIGVAATKTFLTQTLFLSWISIL
HHHHHHHCCEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LAGETGRLNSNEAAKLLEELRNAPRYVEESLSMSSETVKKLAEKLVPVKSMYYLSRDIGL
HCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
PVAREGALKIKEIAYIHAEAYPAGESKHGPIALVEPSFPVVFTVPSDRKLEKLLLGNIEE
CCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCHHH
MKARGGFVISVAPQGFNLNERADIVIEVPRTHWILTSLTHTPPLQLLAYYVATMKGLDPD
HHHCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
KPRNLAKTVTVE
CCCCCCCEEECC
>Mature Secondary Structure
MCGIIGLCLHDKNTLRLGEAIYRGLLRLEYRGYDSAGIAVISDNGLIILKGKGKLNELEG
CCCEEEEEEECCCHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCC
KYSFTSLEGITGIGHTRWATHGAPNDVNAHPHTDCNNMFAIVHNGVIENYMELKKILALK
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GHVFKSETDTEIVAHLIEEYYKETGSVYQAFKKAISSLRGTYAILLITPLEPHKIFYARK
CCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEC
DSPLVIGVGNGYNAVASDIPALLEHTRRVIVIRDGWIGYITPSEIHIEELDTGRILESSR
CCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCEEEEECCCEEEEEECCCCCEECCCC
YIRVVEWDLKDAEKEGYPFFMIKEIYEQPRALRSTIHGLVNDVIIDEAVKLLADADKVFI
EEEEEEECCCCCCCCCCCEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TGAGTSYHASEYFALTTMKLSGKPVIPFIASEYEVYAGVVGSSDILIAVSQSGETMDTMK
EECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHH
AVRAFKAKGCRIISLTNVVDSAIARESDIALYTRAGPEIGVAATKTFLTQTLFLSWISIL
HHHHHHHCCEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LAGETGRLNSNEAAKLLEELRNAPRYVEESLSMSSETVKKLAEKLVPVKSMYYLSRDIGL
HCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
PVAREGALKIKEIAYIHAEAYPAGESKHGPIALVEPSFPVVFTVPSDRKLEKLLLGNIEE
CCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCHHH
MKARGGFVISVAPQGFNLNERADIVIEVPRTHWILTSLTHTPPLQLLAYYVATMKGLDPD
HHHCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
KPRNLAKTVTVE
CCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]