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The map label for this gene is fen [H]

Identifier: 218884379

GI number: 218884379

Start: 1012615

End: 1013706

Strand: Reverse

Name: fen [H]

Synonym: DKAM_1068

Alternate gene names: 218884379

Gene position: 1013706-1012615 (Counterclockwise)

Preceding gene: 218884380

Following gene: 218884376

Centisome position: 74.25

GC content: 45.7

Gene sequence:

>1092_bases
ATGTATATTGATCAGCATAATGGTGTAGATATGGGAGTAGACTTAAAAGACATTATACCAGGCGAAGCTAAAACGGTTAT
CGAGGATCTCAGGATCCTACATGGCAAGATTATAGTGATAGATGGCTATAACGCATTATACCAGTTCCTAGCTGCAATCA
GACAACCGGATGGGACCCCTCTAATGGATAACAACGGGAGGATCACGAGTCATTTAAGCGGTTTATTCTATAGAACCATA
AATATCGTTGAGGCAGGGATAAAACCAGTCTACGTGTTTGATGGTAAACCCCCTGAATTGAAGGCGAGGGAGATAGAGAG
GAGGAAAGCCGTTAAGGAGGAGGCAGCAAAGAAGTACGAGGAAGCCGTTCAATCCGGAGACCTCGAGCTCGCGAGGAGAT
ACGCAATGATGTCGGCCAAGCTGACAGAGGAAATGGTGAGGGATGCTAAATCATTACTAGACGCAATGGGTATTCCATGG
GTTCAAGCACCAGCGGAGGGCGAGGCTCAGGCAGCCTATATTGTTAAGAAGGGGGATGCCTATGCATCCGCCTCACAGGA
TTACGATAGCTTGCTATTCGGCTCCCCTAAGCTCGTTAGAAACCTGACCATAAGCGGTAGGAGAAAGCTACCGAGAAAAA
ACGAGTATGTTGAAGTAAAGCCGGAGCTCATAGAGCTCGACAAACTCCTTGTTCAGCTAGGTATAACCCTTGAGAACCTC
ATCGATATAGGTATACTCCTGGGGACAGATTACAATCCAGACGGCTTCGAAGGCATAGGCCCCAAGAAGGCTCTTCAACT
AGTTAAGGCATACGGGGGAATCGAGAAGATACCGAAACCCATTTTGAAGTCGCCGATAGAAGTAGATGTTATAGCAATAA
AGAAATACTTCCTTCAACCACAGGTAACAGACAACTACAGGATTGAATGGCATACCCCCGATCCCGATGCAGTGAAAAGA
ATATTGGTGGATGAACATGATTTCAGTATAGATAGAGTTAGCACAGCGCTTGAGAGATACGTGAAGGCCTTTAAAGAAAA
TATACGGGGAGAACAGAAAGGTCTCTCTAAATGGTTCAGTAAGCCGAAGTAG

Upstream 100 bases:

>100_bases
TAATACAGGTTGAACCAGTTGGGAAGGAGTTCTTCGTGAAATTGTCTCCCAGGTTCAATGAGTATATAAAGTAACCTCTT
CGAGTTAAATATTTAACACC

Downstream 100 bases:

>100_bases
TTGGGTTTCCAGGATTTCTGCAGCAACTGTTTCCCGCTCTAAGTCGTTGTAGGTTTTGCCGGGACCGGTTGTGCCTCTGC
TCACGCTTCACCGTGGGCAT

Product: flap endonuclease-1

Products: NA

Alternate protein names: FEN-1; Flap structure-specific endonuclease 1 [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MYIDQHNGVDMGVDLKDIIPGEAKTVIEDLRILHGKIIVIDGYNALYQFLAAIRQPDGTPLMDNNGRITSHLSGLFYRTI
NIVEAGIKPVYVFDGKPPELKAREIERRKAVKEEAAKKYEEAVQSGDLELARRYAMMSAKLTEEMVRDAKSLLDAMGIPW
VQAPAEGEAQAAYIVKKGDAYASASQDYDSLLFGSPKLVRNLTISGRRKLPRKNEYVEVKPELIELDKLLVQLGITLENL
IDIGILLGTDYNPDGFEGIGPKKALQLVKAYGGIEKIPKPILKSPIEVDVIAIKKYFLQPQVTDNYRIEWHTPDPDAVKR
ILVDEHDFSIDRVSTALERYVKAFKENIRGEQKGLSKWFSKPK

Sequences:

>Translated_363_residues
MYIDQHNGVDMGVDLKDIIPGEAKTVIEDLRILHGKIIVIDGYNALYQFLAAIRQPDGTPLMDNNGRITSHLSGLFYRTI
NIVEAGIKPVYVFDGKPPELKAREIERRKAVKEEAAKKYEEAVQSGDLELARRYAMMSAKLTEEMVRDAKSLLDAMGIPW
VQAPAEGEAQAAYIVKKGDAYASASQDYDSLLFGSPKLVRNLTISGRRKLPRKNEYVEVKPELIELDKLLVQLGITLENL
IDIGILLGTDYNPDGFEGIGPKKALQLVKAYGGIEKIPKPILKSPIEVDVIAIKKYFLQPQVTDNYRIEWHTPDPDAVKR
ILVDEHDFSIDRVSTALERYVKAFKENIRGEQKGLSKWFSKPK
>Mature_363_residues
MYIDQHNGVDMGVDLKDIIPGEAKTVIEDLRILHGKIIVIDGYNALYQFLAAIRQPDGTPLMDNNGRITSHLSGLFYRTI
NIVEAGIKPVYVFDGKPPELKAREIERRKAVKEEAAKKYEEAVQSGDLELARRYAMMSAKLTEEMVRDAKSLLDAMGIPW
VQAPAEGEAQAAYIVKKGDAYASASQDYDSLLFGSPKLVRNLTISGRRKLPRKNEYVEVKPELIELDKLLVQLGITLENL
IDIGILLGTDYNPDGFEGIGPKKALQLVKAYGGIEKIPKPILKSPIEVDVIAIKKYFLQPQVTDNYRIEWHTPDPDAVKR
ILVDEHDFSIDRVSTALERYVKAFKENIRGEQKGLSKWFSKPK

Specific function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymeras

COG id: COG0258

COG function: function code L; 5'-3' exonuclease (including N-terminal domain of PolI)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758356, Length=349, Percent_Identity=36.676217765043, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI194018535, Length=250, Percent_Identity=27.6, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194018531, Length=250, Percent_Identity=27.6, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17510005, Length=349, Percent_Identity=35.8166189111748, Blast_Score=215, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322736, Length=346, Percent_Identity=38.150289017341, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6324607, Length=251, Percent_Identity=27.0916334661355, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321697, Length=197, Percent_Identity=28.9340101522843, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320469, Length=277, Percent_Identity=25.9927797833935, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647423, Length=321, Percent_Identity=39.5638629283489, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24658219, Length=211, Percent_Identity=28.436018957346, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020045
- InterPro:   IPR019973
- InterPro:   IPR008918
- InterPro:   IPR006086
- InterPro:   IPR006085
- InterPro:   IPR006084 [H]

Pfam domain/function: PF00867 XPG_I; PF00752 XPG_N [H]

EC number: 3.-.-.-

Molecular weight: Translated: 40822; Mature: 40822

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00841 XPG_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIDQHNGVDMGVDLKDIIPGEAKTVIEDLRILHGKIIVIDGYNALYQFLAAIRQPDGTP
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCC
LMDNNGRITSHLSGLFYRTINIVEAGIKPVYVFDGKPPELKAREIERRKAVKEEAAKKYE
EECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
EAVQSGDLELARRYAMMSAKLTEEMVRDAKSLLDAMGIPWVQAPAEGEAQAAYIVKKGDA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCC
YASASQDYDSLLFGSPKLVRNLTISGRRKLPRKNEYVEVKPELIELDKLLVQLGITLENL
HHCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCHHHH
IDIGILLGTDYNPDGFEGIGPKKALQLVKAYGGIEKIPKPILKSPIEVDVIAIKKYFLQP
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHHHHCCCCCEEHHHHHHHHCCC
QVTDNYRIEWHTPDPDAVKRILVDEHDFSIDRVSTALERYVKAFKENIRGEQKGLSKWFS
CCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
KPK
CCC
>Mature Secondary Structure
MYIDQHNGVDMGVDLKDIIPGEAKTVIEDLRILHGKIIVIDGYNALYQFLAAIRQPDGTP
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCC
LMDNNGRITSHLSGLFYRTINIVEAGIKPVYVFDGKPPELKAREIERRKAVKEEAAKKYE
EECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
EAVQSGDLELARRYAMMSAKLTEEMVRDAKSLLDAMGIPWVQAPAEGEAQAAYIVKKGDA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCC
YASASQDYDSLLFGSPKLVRNLTISGRRKLPRKNEYVEVKPELIELDKLLVQLGITLENL
HHCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCHHHH
IDIGILLGTDYNPDGFEGIGPKKALQLVKAYGGIEKIPKPILKSPIEVDVIAIKKYFLQP
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHHHHCCCCCEEHHHHHHHHCCC
QVTDNYRIEWHTPDPDAVKRILVDEHDFSIDRVSTALERYVKAFKENIRGEQKGLSKWFS
CCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
KPK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA