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The map label for this gene is 218884369

Identifier: 218884369

GI number: 218884369

Start: 1005213

End: 1006064

Strand: Reverse

Name: 218884369

Synonym: DKAM_1058

Alternate gene names: NA

Gene position: 1006064-1005213 (Counterclockwise)

Preceding gene: 218884372

Following gene: 218884368

Centisome position: 73.69

GC content: 43.08

Gene sequence:

>852_bases
GTGGTGGGGGACTTGATCAGGTTTAATCATGAGAGAGCCTGCTTCATAGGTAGGAGAATAAGTATGCTTAAACATGTTAT
TGAGATATTAAGGCATACCGATCCTCAGTTTAAAGCTGTTGAGTCCCTAATCAGCTCGCGAGGTGTAAATGAGGCATCGA
TATTAATCATAGCTAATAGTTTAATCAGTTACCAGCTAAGTGTGAAGGGTGAGGAGTATTGGGTCATGTTCTCCCACTAC
TTCAGTGATAAAGGCAAGAGTGTGGGCTTAAACGAGTTCACTAGTTTCATGGGTTTAAGTGGGAACACTAGGCTCCTGGA
TCAAAAGAAGCGGAGGCTTGCTAGGTTCCTCTCATCCAGTATTGTGAGAGAGCTTTCGGACGATGGATTAAAATACTGCG
TAGATCTCTTGGAGCTAAATAGGCAACTATCCATGCTCTACGGTGGTGACTACTCTAAAACCGTGGTCTTCGCTGTTAAA
ATGTACAGTTACCTCTGTGAGGCCTCAGGAGTGAAGCCACTTACAGCCGGCATTAAACCCCCATTAGACATGAGGAATGC
TTTGTTCCTCTTATCCTCCTGTATTGTTGAGGGATGCGGTGCTGATACTGAATGCGTAGGTAAAATAATGAGTGGGCGAC
ACAGGAATGAGGCGGTTAACGCGTTGTTAAAGGTGTGTGAATGCGGTGGATTAAATTGTATAGAATTAGACGTGTTCACC
TGGCTTGTAACAGGAGTTCTAAGAGATACCGGGTTTAATGTCTATAAGTCCAGTAGATTGATCAAAGAGAGATATGGTGT
TGAAATACCCGTCGATACTCTACAAGAGATATCTCTATGTGTTAAGAGTTAA

Upstream 100 bases:

>100_bases
GGGACCCCCACTCTTTAGGGCGGGGTGGAGGTCAGCTTGAATCGTTAAGCAGGGTTAGAGTTTAAGTTAAAGATTATTTT
GAGAATTTCTTCTAGTTGAT

Downstream 100 bases:

>100_bases
TGCGTTAAATGGTGATCATGGATGAGTAGTAAGGGTTTACAGGATGTGGTGAACATTCTTGAGAAGATATGTAGGGTATT
ATATGATGACTCCCTGGATC

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; AGOG; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MVGDLIRFNHERACFIGRRISMLKHVIEILRHTDPQFKAVESLISSRGVNEASILIIANSLISYQLSVKGEEYWVMFSHY
FSDKGKSVGLNEFTSFMGLSGNTRLLDQKKRRLARFLSSSIVRELSDDGLKYCVDLLELNRQLSMLYGGDYSKTVVFAVK
MYSYLCEASGVKPLTAGIKPPLDMRNALFLLSSCIVEGCGADTECVGKIMSGRHRNEAVNALLKVCECGGLNCIELDVFT
WLVTGVLRDTGFNVYKSSRLIKERYGVEIPVDTLQEISLCVKS

Sequences:

>Translated_283_residues
MVGDLIRFNHERACFIGRRISMLKHVIEILRHTDPQFKAVESLISSRGVNEASILIIANSLISYQLSVKGEEYWVMFSHY
FSDKGKSVGLNEFTSFMGLSGNTRLLDQKKRRLARFLSSSIVRELSDDGLKYCVDLLELNRQLSMLYGGDYSKTVVFAVK
MYSYLCEASGVKPLTAGIKPPLDMRNALFLLSSCIVEGCGADTECVGKIMSGRHRNEAVNALLKVCECGGLNCIELDVFT
WLVTGVLRDTGFNVYKSSRLIKERYGVEIPVDTLQEISLCVKS
>Mature_283_residues
MVGDLIRFNHERACFIGRRISMLKHVIEILRHTDPQFKAVESLISSRGVNEASILIIANSLISYQLSVKGEEYWVMFSHY
FSDKGKSVGLNEFTSFMGLSGNTRLLDQKKRRLARFLSSSIVRELSDDGLKYCVDLLELNRQLSMLYGGDYSKTVVFAVK
MYSYLCEASGVKPLTAGIKPPLDMRNALFLLSSCIVEGCGADTECVGKIMSGRHRNEAVNALLKVCECGGLNCIELDVFT
WLVTGVLRDTGFNVYKSSRLIKERYGVEIPVDTLQEISLCVKS

Specific function: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates [H]

COG id: COG4047

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR023170
- InterPro:   IPR015254
- InterPro:   IPR016544 [H]

Pfam domain/function: PF09171 DUF1886 [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 31681; Mature: 31681

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGDLIRFNHERACFIGRRISMLKHVIEILRHTDPQFKAVESLISSRGVNEASILIIANS
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEHH
LISYQLSVKGEEYWVMFSHYFSDKGKSVGLNEFTSFMGLSGNTRLLDQKKRRLARFLSSS
HHHEEEEECCCEEEEEHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IVRELSDDGLKYCVDLLELNRQLSMLYGGDYSKTVVFAVKMYSYLCEASGVKPLTAGIKP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PLDMRNALFLLSSCIVEGCGADTECVGKIMSGRHRNEAVNALLKVCECGGLNCIELDVFT
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHHHH
WLVTGVLRDTGFNVYKSSRLIKERYGVEIPVDTLQEISLCVKS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVGDLIRFNHERACFIGRRISMLKHVIEILRHTDPQFKAVESLISSRGVNEASILIIANS
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEHH
LISYQLSVKGEEYWVMFSHYFSDKGKSVGLNEFTSFMGLSGNTRLLDQKKRRLARFLSSS
HHHEEEEECCCEEEEEHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IVRELSDDGLKYCVDLLELNRQLSMLYGGDYSKTVVFAVKMYSYLCEASGVKPLTAGIKP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PLDMRNALFLLSSCIVEGCGADTECVGKIMSGRHRNEAVNALLKVCECGGLNCIELDVFT
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHHHH
WLVTGVLRDTGFNVYKSSRLIKERYGVEIPVDTLQEISLCVKS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]