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The map label for this gene is tfbB [H]

Identifier: 218884233

GI number: 218884233

Start: 878091

End: 878879

Strand: Reverse

Name: tfbB [H]

Synonym: DKAM_0922

Alternate gene names: 218884233

Gene position: 878879-878091 (Counterclockwise)

Preceding gene: 218884234

Following gene: 218884230

Centisome position: 64.38

GC content: 42.46

Gene sequence:

>789_bases
GTGGTTGAGGAGAAGCTTACCTATCAGGGTTTCGAGGGCTTCTTGAAGAATAACAATACCCCACGGTACAGTGGCATGTT
TACAAACATGGTTCATGACCATGGTGTAGGAGGGACTGAGATATCTGGTTACTTCATGCGACACCTGAAACAAGGAAGGA
GCTGGGTTAGAGTTAACAGTGAGATAAAGGTTGAGAAGAAGGATAGGAAGCTTAAAAAAGCGCTGCAGGAGTTAAACGAG
TATCTGAAGCTCATTAATCCTCCGCCAGCTGTAAAGGAGACAGCTGCAAAACTTGTCCATGAAGCGGTAAAGGATAAGAA
TTACAAGGAGAGTACATTGAGAAAGATAATCATAGCAGCTATCTATTTATCATATAGGATTAATGATACCCCTAAGTCTT
TAAAGGTATTTATATCAGAGCTAAACGTCGATGAGAAAGACTTATGGGAGGGAGTGAGGTTAATACGTGAATCTAATAGC
AATATAAAGATTTCCAGGGAAAACTTTGATCCGAGGCGTTACGTGGGTTATATTATACGCAAGCTGAATGCTCCACCGAT
CGTTGAGACTATGGCGAACTATATTATATCAGTGACCGAGGAACAGGGATTTATAAGCGGTAAAAGCCCGACGAGCCTGG
CAGCCGCAGCAGTATATCTAGCAGGGATTCTCACCAATAATAAGAGGAACCAGGTTGAGGTTGCTGAAACCGTGGGCCTT
AGCGATGTAGCTATAAGGAACGCGTATGGCTCAATCATAAAAGACGTTGACATAGAGGTTTTACTTTAA

Upstream 100 bases:

>100_bases
ATAAAAGGAGTGAGAGACGTTGAAGTGTCCCCACTGCGGCAGCACAAACATAATATTCGATCCAGATTCAAACAGCTATA
TATGCCAGTCATGCGGCTTG

Downstream 100 bases:

>100_bases
GCACGAACATTAAAGTAGTCTATGGATGCACCAAGCAACTTGGCCGCTGCCACTAGATCATCCATATAATCCCCTATTAT
TAAGGCATAGTGATTCCCGA

Product: transcription initiation factor TFIIIB

Products: NA

Alternate protein names: TFIIB 2 [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVEEKLTYQGFEGFLKNNNTPRYSGMFTNMVHDHGVGGTEISGYFMRHLKQGRSWVRVNSEIKVEKKDRKLKKALQELNE
YLKLINPPPAVKETAAKLVHEAVKDKNYKESTLRKIIIAAIYLSYRINDTPKSLKVFISELNVDEKDLWEGVRLIRESNS
NIKISRENFDPRRYVGYIIRKLNAPPIVETMANYIISVTEEQGFISGKSPTSLAAAAVYLAGILTNNKRNQVEVAETVGL
SDVAIRNAYGSIIKDVDIEVLL

Sequences:

>Translated_262_residues
MVEEKLTYQGFEGFLKNNNTPRYSGMFTNMVHDHGVGGTEISGYFMRHLKQGRSWVRVNSEIKVEKKDRKLKKALQELNE
YLKLINPPPAVKETAAKLVHEAVKDKNYKESTLRKIIIAAIYLSYRINDTPKSLKVFISELNVDEKDLWEGVRLIRESNS
NIKISRENFDPRRYVGYIIRKLNAPPIVETMANYIISVTEEQGFISGKSPTSLAAAAVYLAGILTNNKRNQVEVAETVGL
SDVAIRNAYGSIIKDVDIEVLL
>Mature_262_residues
MVEEKLTYQGFEGFLKNNNTPRYSGMFTNMVHDHGVGGTEISGYFMRHLKQGRSWVRVNSEIKVEKKDRKLKKALQELNE
YLKLINPPPAVKETAAKLVHEAVKDKNYKESTLRKIIIAAIYLSYRINDTPKSLKVFISELNVDEKDLWEGVRLIRESNS
NIKISRENFDPRRYVGYIIRKLNAPPIVETMANYIISVTEEQGFISGKSPTSLAAAAVYLAGILTNNKRNQVEVAETVGL
SDVAIRNAYGSIIKDVDIEVLL

Specific function: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) [H]

COG id: COG1405

COG function: function code K; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TFIIB-type zinc finger [H]

Homologues:

Organism=Homo sapiens, GI4504193, Length=186, Percent_Identity=24.7311827956989, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17564892, Length=184, Percent_Identity=22.2826086956522, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17136758, Length=186, Percent_Identity=25.2688172043011, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006670
- InterPro:   IPR011028
- InterPro:   IPR013763
- InterPro:   IPR000812
- InterPro:   IPR013150
- InterPro:   IPR013137 [H]

Pfam domain/function: PF00382 TFIIB; PF08271 TFIIB_Zn_Ribbon [H]

EC number: NA

Molecular weight: Translated: 29708; Mature: 29708

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEEKLTYQGFEGFLKNNNTPRYSGMFTNMVHDHGVGGTEISGYFMRHLKQGRSWVRVNS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECC
EIKVEKKDRKLKKALQELNEYLKLINPPPAVKETAAKLVHEAVKDKNYKESTLRKIIIAA
EEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IYLSYRINDTPKSLKVFISELNVDEKDLWEGVRLIRESNSNIKISRENFDPRRYVGYIIR
HHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
KLNAPPIVETMANYIISVTEEQGFISGKSPTSLAAAAVYLAGILTNNKRNQVEVAETVGL
HCCCCHHHHHHHHHHEEECCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
SDVAIRNAYGSIIKDVDIEVLL
HHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure
MVEEKLTYQGFEGFLKNNNTPRYSGMFTNMVHDHGVGGTEISGYFMRHLKQGRSWVRVNS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECC
EIKVEKKDRKLKKALQELNEYLKLINPPPAVKETAAKLVHEAVKDKNYKESTLRKIIIAA
EEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IYLSYRINDTPKSLKVFISELNVDEKDLWEGVRLIRESNSNIKISRENFDPRRYVGYIIR
HHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
KLNAPPIVETMANYIISVTEEQGFISGKSPTSLAAAAVYLAGILTNNKRNQVEVAETVGL
HCCCCHHHHHHHHHHEEECCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
SDVAIRNAYGSIIKDVDIEVLL
HHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]