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The map label for this gene is pepQ [H]

Identifier: 218884226

GI number: 218884226

Start: 870324

End: 871430

Strand: Reverse

Name: pepQ [H]

Synonym: DKAM_0915

Alternate gene names: 218884226

Gene position: 871430-870324 (Counterclockwise)

Preceding gene: 218884228

Following gene: 218884224

Centisome position: 63.83

GC content: 45.71

Gene sequence:

>1107_bases
ATGAGTAGGGAATTAAGGATAGGGAAACTCGTAAGTCTCATGGAGTCCCATGGATTACAGGACATAGTATTGGTCTCCCC
TGAAAATATAGAGTATTATACTGGTGTGGAGACGGTGGCCGATGCCACGCTACTGCTACATGCGACCAGAGGTGGAGGTG
TAAGTATATATGTCCCGCTCCTCGAATACTATAGATACAGGGATTCACTTCCGGGAGAAGTAGAGGTATATGCCTACTCG
AAAACCCTGAAGCCTAGTGATGCAAGGATAGTTGAAAAAGACTACAGGGAGATCCTGAAGGAAATAATCGATAAAAGCAG
CAAGATAGGTATTGACAAACAGCTTCAAGACACCCCGATCCAGCAGGAAACCCATAGCGATAGAGTAGTCGATATCTCAG
GAGACGTGTGGAAGCATAGAATGATTAAGGACGAGAAGGAAATAGAGGCCATCAGGAAGGCAGTTGATATAACCATAAAG
GGGATAAAGACGATCCAGGACAATATATCGGAGGGCGTTACAGAGGCCGAGCTCGCAGGTTTCTTTGAGGAAAGAGTGAG
AAGGGAAGGAGTGAAGAAGTACGCGTTCGACCCAATTATAGCATTTAAACCAGGTAATAGCTATCCCCATATTCTACCAG
GTAGTAAGAAGCTGGGTAGGAGAGATCTCGTGTTAATTGATGTTGGTGTTAAATACAGGGGTAGATGCAGTGATTTAACG
AGGATGATTACATGGGGCAGACCCACCCCTGATGAAAGAAGGAGCCTGGAAGCAGTAGAGGAGGCGCTCTGGGAATCCAT
TGACAGTATCTACCCAGGCATTAAAGCTGGTGATGTTGCTGAGAAAGCTGTTAAAAAACTTGAGAAATATGGCTTACATG
AGAGATTCATACATGGGTTAGGCCATGGAATAGGTATAGCTGTACATGAACCCCCATATCTTAGGCTTGGAGGCTCGACA
CTGCTTGAGCCAGGGATGGTCTTCACTATTGAGCCAGGCGTGTATTTTAACGGTAGGTATGGCGTGAGAATGGAGGAAGA
TGTATTGGTGACCAGGAAGGGTGTTAGAGTGCTTTCACGCAGGCTTAAACCATTGCTGATGCTATAG

Upstream 100 bases:

>100_bases
TACCTCAATGCTCAAGTATATCACCACGCATTCACAATACCTCCATAGTTTATATTTGTTTCAAGCATTAATAACTCATT
GATTACTAGGGTTGAATGAT

Downstream 100 bases:

>100_bases
TTTTTCAACTAGCGAACCATTTTCTCCTTATTTCATTAATTATTGAATCGTTACTTGGGCCGATTACAAGCCTCCTTACT
ATCTCCACTTTATCTACCCG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSRELRIGKLVSLMESHGLQDIVLVSPENIEYYTGVETVADATLLLHATRGGGVSIYVPLLEYYRYRDSLPGEVEVYAYS
KTLKPSDARIVEKDYREILKEIIDKSSKIGIDKQLQDTPIQQETHSDRVVDISGDVWKHRMIKDEKEIEAIRKAVDITIK
GIKTIQDNISEGVTEAELAGFFEERVRREGVKKYAFDPIIAFKPGNSYPHILPGSKKLGRRDLVLIDVGVKYRGRCSDLT
RMITWGRPTPDERRSLEAVEEALWESIDSIYPGIKAGDVAEKAVKKLEKYGLHERFIHGLGHGIGIAVHEPPYLRLGGST
LLEPGMVFTIEPGVYFNGRYGVRMEEDVLVTRKGVRVLSRRLKPLLML

Sequences:

>Translated_368_residues
MSRELRIGKLVSLMESHGLQDIVLVSPENIEYYTGVETVADATLLLHATRGGGVSIYVPLLEYYRYRDSLPGEVEVYAYS
KTLKPSDARIVEKDYREILKEIIDKSSKIGIDKQLQDTPIQQETHSDRVVDISGDVWKHRMIKDEKEIEAIRKAVDITIK
GIKTIQDNISEGVTEAELAGFFEERVRREGVKKYAFDPIIAFKPGNSYPHILPGSKKLGRRDLVLIDVGVKYRGRCSDLT
RMITWGRPTPDERRSLEAVEEALWESIDSIYPGIKAGDVAEKAVKKLEKYGLHERFIHGLGHGIGIAVHEPPYLRLGGST
LLEPGMVFTIEPGVYFNGRYGVRMEEDVLVTRKGVRVLSRRLKPLLML
>Mature_367_residues
SRELRIGKLVSLMESHGLQDIVLVSPENIEYYTGVETVADATLLLHATRGGGVSIYVPLLEYYRYRDSLPGEVEVYAYSK
TLKPSDARIVEKDYREILKEIIDKSSKIGIDKQLQDTPIQQETHSDRVVDISGDVWKHRMIKDEKEIEAIRKAVDITIKG
IKTIQDNISEGVTEAELAGFFEERVRREGVKKYAFDPIIAFKPGNSYPHILPGSKKLGRRDLVLIDVGVKYRGRCSDLTR
MITWGRPTPDERRSLEAVEEALWESIDSIYPGIKAGDVAEKAVKKLEKYGLHERFIHGLGHGIGIAVHEPPYLRLGGSTL
LEPGMVFTIEPGVYFNGRYGVRMEEDVLVTRKGVRVLSRRLKPLLML

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=308, Percent_Identity=26.6233766233766, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI93141226, Length=240, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI149589008, Length=283, Percent_Identity=26.1484098939929, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI260593665, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI264681563, Length=189, Percent_Identity=31.7460317460317, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788728, Length=233, Percent_Identity=36.0515021459227, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789275, Length=268, Percent_Identity=27.9850746268657, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786364, Length=237, Percent_Identity=27.4261603375527, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71989583, Length=319, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321118, Length=279, Percent_Identity=28.673835125448, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920384, Length=255, Percent_Identity=29.0196078431373, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583427, Length=259, Percent_Identity=24.7104247104247, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=25.2032520325203, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 41618; Mature: 41486

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRELRIGKLVSLMESHGLQDIVLVSPENIEYYTGVETVADATLLLHATRGGGVSIYVPL
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEECCHHHHHCEEEEEEEECCCCEEEEHHH
LEYYRYRDSLPGEVEVYAYSKTLKPSDARIVEKDYREILKEIIDKSSKIGIDKQLQDTPI
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QQETHSDRVVDISGDVWKHRMIKDEKEIEAIRKAVDITIKGIKTIQDNISEGVTEAELAG
CCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFEERVRREGVKKYAFDPIIAFKPGNSYPHILPGSKKLGRRDLVLIDVGVKYRGRCSDLT
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHH
RMITWGRPTPDERRSLEAVEEALWESIDSIYPGIKAGDVAEKAVKKLEKYGLHERFIHGL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHC
GHGIGIAVHEPPYLRLGGSTLLEPGMVFTIEPGVYFNGRYGVRMEEDVLVTRKGVRVLSR
CCCCEEEEECCCEEEECCCHHCCCCEEEEECCCEEECCEECCEECCCHHHHHHHHHHHHH
RLKPLLML
HHHHHHCC
>Mature Secondary Structure 
SRELRIGKLVSLMESHGLQDIVLVSPENIEYYTGVETVADATLLLHATRGGGVSIYVPL
CCCCHHHHHHHHHHHCCCCEEEEECCCCCEEECCHHHHHCEEEEEEEECCCCEEEEHHH
LEYYRYRDSLPGEVEVYAYSKTLKPSDARIVEKDYREILKEIIDKSSKIGIDKQLQDTPI
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
QQETHSDRVVDISGDVWKHRMIKDEKEIEAIRKAVDITIKGIKTIQDNISEGVTEAELAG
CCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFEERVRREGVKKYAFDPIIAFKPGNSYPHILPGSKKLGRRDLVLIDVGVKYRGRCSDLT
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHH
RMITWGRPTPDERRSLEAVEEALWESIDSIYPGIKAGDVAEKAVKKLEKYGLHERFIHGL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHC
GHGIGIAVHEPPYLRLGGSTLLEPGMVFTIEPGVYFNGRYGVRMEEDVLVTRKGVRVLSR
CCCCEEEEECCCEEEECCCHHCCCCEEEEECCCEEECCEECCEECCCHHHHHHHHHHHHH
RLKPLLML
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]