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The map label for this gene is upp [H]

Identifier: 218884141

GI number: 218884141

Start: 800591

End: 801256

Strand: Direct

Name: upp [H]

Synonym: DKAM_0830

Alternate gene names: 218884141

Gene position: 800591-801256 (Clockwise)

Preceding gene: 218884140

Following gene: 218884145

Centisome position: 58.64

GC content: 45.8

Gene sequence:

>666_bases
ATGTTCGAGGTTAGATTAGTCAATAGGAAGTATGCCCAGGCCATCCTCACTACTCTACGTGACAAGAACACCAGCCAGAT
AGAGTTCCGCAAGGGACTAGTGAGGTTGGGACGGATACTTGGATTAGAAATAATTGAGGATCTTGAATGCGAAACAATTG
AGGTTGAAACACCGCTGGGTGCCAGGGTACATGGCTGTAGGATAAAGGATTTAGACAACGTTATAATAATAACAGTGCTT
AGAGCAGCCTGGCCTCTAACCGAGGGATTAATTAAGATCCTGTATACAGCTAGACAGGGGGTAGTCGTTGCCAGGCGTGT
AGAGGAGAAAGGAATGAAGGCTGGTTCCTTCGAGATAGAAGTATCCTATGTGAAAACACCGAGGATAACAAACAGGGATA
TAATTGTCATAAGCGATGTAATGATTGCCACAGCTTCGACACTGGTGAACGTGCTGGAGAAATTAAGGGAGAGGGGGACG
GCTAAGAAATACTATGTAGCATCAGTTATAACGACACCATACGCTATAAGCAGGTTGAAGAAATATGCCGAGGAATCCGG
AGTGGACTTAAAACTATACACTATCGCGGTTGACCCAGAGGTGAATGAAAAAGGATACATAGTCCCCGGTCTCGGGGACG
CTGGAGATAGGGCATTCGGCTCTTAG

Upstream 100 bases:

>100_bases
AATGGGCTCCCAGATAACACTATATATTATGAGGCACTCTACACAGAGCACTAGTCATAGTTTTAAAAAATTCCCATGGC
ATATTTAAACAAGGGTATAG

Downstream 100 bases:

>100_bases
CCAAATACCCGTGTAATCCACTCCATATCCAGTTTTTTATATCTCTCAAGGCTTCCCACGTCAAACCATTCTCCATTATA
TATGTATGCCTTGACCCGGT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MFEVRLVNRKYAQAILTTLRDKNTSQIEFRKGLVRLGRILGLEIIEDLECETIEVETPLGARVHGCRIKDLDNVIIITVL
RAAWPLTEGLIKILYTARQGVVVARRVEEKGMKAGSFEIEVSYVKTPRITNRDIIVISDVMIATASTLVNVLEKLRERGT
AKKYYVASVITTPYAISRLKKYAEESGVDLKLYTIAVDPEVNEKGYIVPGLGDAGDRAFGS

Sequences:

>Translated_221_residues
MFEVRLVNRKYAQAILTTLRDKNTSQIEFRKGLVRLGRILGLEIIEDLECETIEVETPLGARVHGCRIKDLDNVIIITVL
RAAWPLTEGLIKILYTARQGVVVARRVEEKGMKAGSFEIEVSYVKTPRITNRDIIVISDVMIATASTLVNVLEKLRERGT
AKKYYVASVITTPYAISRLKKYAEESGVDLKLYTIAVDPEVNEKGYIVPGLGDAGDRAFGS
>Mature_221_residues
MFEVRLVNRKYAQAILTTLRDKNTSQIEFRKGLVRLGRILGLEIIEDLECETIEVETPLGARVHGCRIKDLDNVIIITVL
RAAWPLTEGLIKILYTARQGVVVARRVEEKGMKAGSFEIEVSYVKTPRITNRDIIVISDVMIATASTLVNVLEKLRERGT
AKKYYVASVITTPYAISRLKKYAEESGVDLKLYTIAVDPEVNEKGYIVPGLGDAGDRAFGS

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Escherichia coli, GI87082118, Length=206, Percent_Identity=30.5825242718447, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=207, Percent_Identity=25.6038647342995, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24657; Mature: 24657

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEVRLVNRKYAQAILTTLRDKNTSQIEFRKGLVRLGRILGLEIIEDLECETIEVETPLG
CEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ARVHGCRIKDLDNVIIITVLRAAWPLTEGLIKILYTARQGVVVARRVEEKGMKAGSFEIE
CCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCEEEE
VSYVKTPRITNRDIIVISDVMIATASTLVNVLEKLRERGTAKKYYVASVITTPYAISRLK
EEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCHHHHHHHH
KYAEESGVDLKLYTIAVDPEVNEKGYIVPGLGDAGDRAFGS
HHHHHCCCEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MFEVRLVNRKYAQAILTTLRDKNTSQIEFRKGLVRLGRILGLEIIEDLECETIEVETPLG
CEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ARVHGCRIKDLDNVIIITVLRAAWPLTEGLIKILYTARQGVVVARRVEEKGMKAGSFEIE
CCCCCCEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCEEEE
VSYVKTPRITNRDIIVISDVMIATASTLVNVLEKLRERGTAKKYYVASVITTPYAISRLK
EEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCHHHHHHHH
KYAEESGVDLKLYTIAVDPEVNEKGYIVPGLGDAGDRAFGS
HHHHHCCCEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA