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The map label for this gene is mtaD [H]

Identifier: 218883554

GI number: 218883554

Start: 226040

End: 227455

Strand: Direct

Name: mtaD [H]

Synonym: DKAM_0243

Alternate gene names: 218883554

Gene position: 226040-227455 (Clockwise)

Preceding gene: 218883552

Following gene: 218883555

Centisome position: 16.56

GC content: 46.54

Gene sequence:

>1416_bases
ATGTGGGTGGGCTATTTGGCGGATATATATATTAGAGGCGGCTGGATAATAACCATGGATTCCTCGAGAAGGATAATTCG
TGACGGTGCTGTAGCAGTAGAGGATGGAGAGGTCAGAGCTGTAGGTAAAAGGGAGGTGCTTGACAAGGATTACCGTTATT
ACTCAGATATAGTAATCAATGCCGAGAGAGACATAGTGATGCCAGGGCTAATCAACACGCATGTACACCTAGCCCAAGGT
CTGCTAAGGGCATGCGCAGACTACCTACCTCTAATCCCCTGGTTGAAGGATAGAGTTTGGCCGCTTCAGGGTAACTATAG
ACCTGAGGAGGCATTAGCATCAGCTAAACTAGTAACCCTTGAAATGATTAAATCGGGGACAACGGCTTTCCTTGAGACAG
GGCTGGTGGGACGCTATGGTGTGGATAATATAGTGGAATTCCTACACGGCTCAGGGATAAGGGCTGCTATTGCTAGACAT
GTAATGGATTTGAAAGGTTATGCATTAGAGGAAAACATCCTGCACGAGGGACTAGTTGAGCCAGGGGACACTAGTTTCAA
TGACACGCTGAGACTACATAGCAAATATCATGGATGGGATAATAGGATATGGATATGGTTTGGGCCAAGAACCCCTGGAG
CCGTAAGCCTTGAACTCTATAGAAAAATCTCTGAGAAAGCCAAGGAGTTGAAGACAGGTATAACAATGCACCTCGCAGAA
GTAAGAGATGACGTTGAATACACCATTAAGACATTTGGTAAAAAACCGGTTGAATTCGCTCACTGGCTAGGATTAACAGG
GTCAAACGCTGTCCTGGTGCACGTAGTATGGGTTAGCGATGAGGAGATAAGGCTTCTCGGTGAAACCGGTACTTCTGTCA
GCCATAATCCATCAAGCAATATGAAGCTGGCTAGTGGGGCAGCCAGGGTCTCGGATATGCTGTCTAATGGGGTTAACGTG
GCCTTGGGGACCGATGGTGGTCCAAGTAATAACACGTATGACTTGGTAAGGGAGATGAAGCATGCTGCACTGCTTCAACC
CCTTAGAACGCTGAGGGCTGACGCGATAAGGGCTGAGCAGGTCCTTGAGATGGCTACTATAAATGGTGCACGGGCATTAA
TGATCGGTAATATTACTGGGAGCATAGAGATCGGTAAAAGGGCGGATATAATAGTGATTGACTACTGGAACCCGCATTTA
CACCCATTAAACAACCCTGTCTCACACATTGTTTATGCTGCCTCGGGACATGATGTAAAACACAGTATTATAGATGGGAG
ATTAGTAATGTTTGATAGGAAAACACTCACGTTAGACGAGGAGGAGATAATAGAGGAGGCAGAGAAGGCGGCTTGGAATC
TGTATAATCGTGCCGGGATATGTGGGAAGCCTGATGTAATATGGCCGCTGGTTTAG

Upstream 100 bases:

>100_bases
GTTGAAACTCGCGAAGTAGGATGGCAATCAACCACCTTTAGCCCTTTTTGATGTATTTCTCACTATGCAGGGTTATTAAC
TTTTATGAAATAAACCAATT

Downstream 100 bases:

>100_bases
CCTTCAATATACAAACAAAAGGGGTTCTGTACACTCTTAATAGACAAGTTTAATCACTGATTCATAAACTATAACACAAT
ATTTTTAATTGAAACAATAG

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MWVGYLADIYIRGGWIITMDSSRRIIRDGAVAVEDGEVRAVGKREVLDKDYRYYSDIVINAERDIVMPGLINTHVHLAQG
LLRACADYLPLIPWLKDRVWPLQGNYRPEEALASAKLVTLEMIKSGTTAFLETGLVGRYGVDNIVEFLHGSGIRAAIARH
VMDLKGYALEENILHEGLVEPGDTSFNDTLRLHSKYHGWDNRIWIWFGPRTPGAVSLELYRKISEKAKELKTGITMHLAE
VRDDVEYTIKTFGKKPVEFAHWLGLTGSNAVLVHVVWVSDEEIRLLGETGTSVSHNPSSNMKLASGAARVSDMLSNGVNV
ALGTDGGPSNNTYDLVREMKHAALLQPLRTLRADAIRAEQVLEMATINGARALMIGNITGSIEIGKRADIIVIDYWNPHL
HPLNNPVSHIVYAASGHDVKHSIIDGRLVMFDRKTLTLDEEEIIEEAEKAAWNLYNRAGICGKPDVIWPLV

Sequences:

>Translated_471_residues
MWVGYLADIYIRGGWIITMDSSRRIIRDGAVAVEDGEVRAVGKREVLDKDYRYYSDIVINAERDIVMPGLINTHVHLAQG
LLRACADYLPLIPWLKDRVWPLQGNYRPEEALASAKLVTLEMIKSGTTAFLETGLVGRYGVDNIVEFLHGSGIRAAIARH
VMDLKGYALEENILHEGLVEPGDTSFNDTLRLHSKYHGWDNRIWIWFGPRTPGAVSLELYRKISEKAKELKTGITMHLAE
VRDDVEYTIKTFGKKPVEFAHWLGLTGSNAVLVHVVWVSDEEIRLLGETGTSVSHNPSSNMKLASGAARVSDMLSNGVNV
ALGTDGGPSNNTYDLVREMKHAALLQPLRTLRADAIRAEQVLEMATINGARALMIGNITGSIEIGKRADIIVIDYWNPHL
HPLNNPVSHIVYAASGHDVKHSIIDGRLVMFDRKTLTLDEEEIIEEAEKAAWNLYNRAGICGKPDVIWPLV
>Mature_471_residues
MWVGYLADIYIRGGWIITMDSSRRIIRDGAVAVEDGEVRAVGKREVLDKDYRYYSDIVINAERDIVMPGLINTHVHLAQG
LLRACADYLPLIPWLKDRVWPLQGNYRPEEALASAKLVTLEMIKSGTTAFLETGLVGRYGVDNIVEFLHGSGIRAAIARH
VMDLKGYALEENILHEGLVEPGDTSFNDTLRLHSKYHGWDNRIWIWFGPRTPGAVSLELYRKISEKAKELKTGITMHLAE
VRDDVEYTIKTFGKKPVEFAHWLGLTGSNAVLVHVVWVSDEEIRLLGETGTSVSHNPSSNMKLASGAARVSDMLSNGVNV
ALGTDGGPSNNTYDLVREMKHAALLQPLRTLRADAIRAEQVLEMATINGARALMIGNITGSIEIGKRADIIVIDYWNPHL
HPLNNPVSHIVYAASGHDVKHSIIDGRLVMFDRKTLTLDEEEIIEEAEKAAWNLYNRAGICGKPDVIWPLV

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=441, Percent_Identity=24.4897959183673, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789249, Length=436, Percent_Identity=25.2293577981651, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082177, Length=447, Percent_Identity=26.1744966442953, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540282, Length=448, Percent_Identity=23.4375, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319963, Length=397, Percent_Identity=23.1738035264484, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643849, Length=403, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 52452; Mature: 52452

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVGYLADIYIRGGWIITMDSSRRIIRDGAVAVEDGEVRAVGKREVLDKDYRYYSDIVIN
CCEEEEEEEEEECCEEEEECCCCEEEECCCEEEECCCEEECCHHHHHHHHHHEEEEEEEE
AERDIVMPGLINTHVHLAQGLLRACADYLPLIPWLKDRVWPLQGNYRPEEALASAKLVTL
CCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EMIKSGTTAFLETGLVGRYGVDNIVEFLHGSGIRAAIARHVMDLKGYALEENILHEGLVE
HHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCC
PGDTSFNDTLRLHSKYHGWDNRIWIWFGPRTPGAVSLELYRKISEKAKELKTGITMHLAE
CCCCCCCCCEEEEHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHH
VRDDVEYTIKTFGKKPVEFAHWLGLTGSNAVLVHVVWVSDEEIRLLGETGTSVSHNPSSN
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
MKLASGAARVSDMLSNGVNVALGTDGGPSNNTYDLVREMKHAALLQPLRTLRADAIRAEQ
CEEHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLEMATINGARALMIGNITGSIEIGKRADIIVIDYWNPHLHPLNNPVSHIVYAASGHDVK
HHHHHHCCCCEEEEEECCCCEEEECCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCCC
HSIIDGRLVMFDRKTLTLDEEEIIEEAEKAAWNLYNRAGICGKPDVIWPLV
HHHCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCC
>Mature Secondary Structure
MWVGYLADIYIRGGWIITMDSSRRIIRDGAVAVEDGEVRAVGKREVLDKDYRYYSDIVIN
CCEEEEEEEEEECCEEEEECCCCEEEECCCEEEECCCEEECCHHHHHHHHHHEEEEEEEE
AERDIVMPGLINTHVHLAQGLLRACADYLPLIPWLKDRVWPLQGNYRPEEALASAKLVTL
CCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EMIKSGTTAFLETGLVGRYGVDNIVEFLHGSGIRAAIARHVMDLKGYALEENILHEGLVE
HHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCC
PGDTSFNDTLRLHSKYHGWDNRIWIWFGPRTPGAVSLELYRKISEKAKELKTGITMHLAE
CCCCCCCCCEEEEHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHH
VRDDVEYTIKTFGKKPVEFAHWLGLTGSNAVLVHVVWVSDEEIRLLGETGTSVSHNPSSN
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
MKLASGAARVSDMLSNGVNVALGTDGGPSNNTYDLVREMKHAALLQPLRTLRADAIRAEQ
CEEHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLEMATINGARALMIGNITGSIEIGKRADIIVIDYWNPHLHPLNNPVSHIVYAASGHDVK
HHHHHHCCCCEEEEEECCCCEEEECCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCCC
HSIIDGRLVMFDRKTLTLDEEEIIEEAEKAAWNLYNRAGICGKPDVIWPLV
HHHCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]