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The map label for this gene is tmk [H]

Identifier: 218883455

GI number: 218883455

Start: 128484

End: 129104

Strand: Reverse

Name: tmk [H]

Synonym: DKAM_0141

Alternate gene names: 218883455

Gene position: 129104-128484 (Counterclockwise)

Preceding gene: 218883456

Following gene: 218883453

Centisome position: 9.46

GC content: 42.35

Gene sequence:

>621_bases
ATGCATGGTAAGGGATGCTTTATTGTGCTGGAGGGACTCGATGGAGCCGGGAAAACAACGGTAGCACGTAGGCTTGTAGA
GGATCTATCCAGTAGAGGGATCCCGGCTTCATACACTTATGAGCCAACAGATTCCGAAATAGTTAGAGTCATCAAGTCTA
CTTATAACAATTTAAGGGACGCGTACATCGATGCATTAGCATTTGCTCTGGATAGATTAATACATGTGAAAAACTGGGTT
AAACCCCTTCTGGATAAGGGTGTAACGGTTATTTCCGATAGATACTTCTATAGTAGTGTTGCATATCAATCAGCTAGTGG
AGCACCGTTTGAATGGGTTATAGAGGTAAATAAGTTCGCCATGAAGCCTGATGTAGCAATCTACCTTGACATAGAGCCTG
AAGAGGGTTTATCCAGGAAGCACATGCATACATCAAGGTTTCCAGAGTACGAGGAGAAGGAGTTCCTACAAAGGGTTAGG
AGCATGTATCTGAGAATGGTGGAGATGGGTCTCTTAATATATATTGATGCATCGAAACCCCTTAGTGAAGTATATGGTAG
GATATGGGATATAGTATATGGGAGACTGATCAGTATGAACAGCCGGGTTTATGATACTTAA

Upstream 100 bases:

>100_bases
ATACCCTTACTAGTGGTAGAGGAGTATGATAACTTCGCAGGCACCCTTAAAAATAAAAACCATCGATATGTAAGATACAC
CCGCGGCTCGGGGATCCTTT

Downstream 100 bases:

>100_bases
GCTTCTTTACGGGGTATCCCGCTTCCTAGCAATAATCTTTAATCGTGCAACCCTTTCAAGTACTTCAAGCCATTTAATTA
TCTCAGTTGAATCGATATCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MHGKGCFIVLEGLDGAGKTTVARRLVEDLSSRGIPASYTYEPTDSEIVRVIKSTYNNLRDAYIDALAFALDRLIHVKNWV
KPLLDKGVTVISDRYFYSSVAYQSASGAPFEWVIEVNKFAMKPDVAIYLDIEPEEGLSRKHMHTSRFPEYEEKEFLQRVR
SMYLRMVEMGLLIYIDASKPLSEVYGRIWDIVYGRLISMNSRVYDT

Sequences:

>Translated_206_residues
MHGKGCFIVLEGLDGAGKTTVARRLVEDLSSRGIPASYTYEPTDSEIVRVIKSTYNNLRDAYIDALAFALDRLIHVKNWV
KPLLDKGVTVISDRYFYSSVAYQSASGAPFEWVIEVNKFAMKPDVAIYLDIEPEEGLSRKHMHTSRFPEYEEKEFLQRVR
SMYLRMVEMGLLIYIDASKPLSEVYGRIWDIVYGRLISMNSRVYDT
>Mature_206_residues
MHGKGCFIVLEGLDGAGKTTVARRLVEDLSSRGIPASYTYEPTDSEIVRVIKSTYNNLRDAYIDALAFALDRLIHVKNWV
KPLLDKGVTVISDRYFYSSVAYQSASGAPFEWVIEVNKFAMKPDVAIYLDIEPEEGLSRKHMHTSRFPEYEEKEFLQRVR
SMYLRMVEMGLLIYIDASKPLSEVYGRIWDIVYGRLISMNSRVYDT

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=188, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1787340, Length=197, Percent_Identity=32.994923857868, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17535647, Length=159, Percent_Identity=31.4465408805031, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322517, Length=206, Percent_Identity=27.6699029126214, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573735, Length=208, Percent_Identity=33.6538461538462, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23667; Mature: 23667

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGKGCFIVLEGLDGAGKTTVARRLVEDLSSRGIPASYTYEPTDSEIVRVIKSTYNNLRD
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AYIDALAFALDRLIHVKNWVKPLLDKGVTVISDRYFYSSVAYQSASGAPFEWVIEVNKFA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCEEEEEEEHHHC
MKPDVAIYLDIEPEEGLSRKHMHTSRFPEYEEKEFLQRVRSMYLRMVEMGLLIYIDASKP
CCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
LSEVYGRIWDIVYGRLISMNSRVYDT
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHGKGCFIVLEGLDGAGKTTVARRLVEDLSSRGIPASYTYEPTDSEIVRVIKSTYNNLRD
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AYIDALAFALDRLIHVKNWVKPLLDKGVTVISDRYFYSSVAYQSASGAPFEWVIEVNKFA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCEEEEEEEHHHC
MKPDVAIYLDIEPEEGLSRKHMHTSRFPEYEEKEFLQRVRSMYLRMVEMGLLIYIDASKP
CCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCC
LSEVYGRIWDIVYGRLISMNSRVYDT
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA