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The map label for this gene is arcB [H]

Identifier: 218883451

GI number: 218883451

Start: 125553

End: 126497

Strand: Reverse

Name: arcB [H]

Synonym: DKAM_0137

Alternate gene names: 218883451

Gene position: 126497-125553 (Counterclockwise)

Preceding gene: 218883453

Following gene: 218883450

Centisome position: 9.27

GC content: 45.5

Gene sequence:

>945_bases
ATGGTGACTAGTCTTAAAGGTAGACACTTCCTAACGCTAGCCGAGTATAGTAGGGAAGAATTATTATTTATGATCAGGAC
AGCAATGCAGTTCAAGCAGAGGTATCTAGCTGGAGAGAGGATAATACCCCTGCTGGTGGGGCGTCACCTAGCGATGATTT
TCGAGAAACCCAGTACTAGAACTAGGATCAGCTTTGAAACAGCCATGAAGGAGCTGGGAGGCGACGCTATATACTTGAGC
GCCAGCGAGCTACAATTAGCCAGAGGCGAGACCATCGAGGACACTGCACGTGTTTTATCAAGGTATGTCGATGTGATAAT
GGCCCGCGTTTATGAACACTATAAGATCGAGAAGCTCGCACAGTACAGTAGGGTCCCAGTAATAAATGGGCTAAGTGATC
TACATCACCCAGCCCAAGCACTAAGCGATGTCTTAACAATAATGGAGAAAAAAGGTGGGGATATCACTAGGCTGAAAATA
GTTTTCGTTGGTGATGGAGGCGATAATGTCCTACATAGCCTGATGCTCGCCACAGGGATACTAGGCGGAAAGATAATCAT
TGCCTCGCCCAAAGGCTATGAGCCACATCCAAGTGTTGTAAAACTTTTCAATGAACACGCCTCACCGAATGGGGGCTCCT
ATGAGATAGAGAGAGATCCATTTAAAGCAGTTGAAAATGCTGACGTAGTATACACTGATGTATGGGTCAGCATGGGACAG
GAAAAGGAGAAGGAGAAGAGGATAAAGGATCTAGAACCATACAGGGTCACAGTAGAGTTAATGAACCATGCAAAGCCAGA
CGCGATATTCATGCATTGTTTACCAGCTCATAGAGGAGAAGAAGTAGTCAACGAAGTCATTGATGGTAAATGGAGTGTTG
TATGGGATCAAGCAGAAAACAGGAAGCACGCACAGAAAGCAATACTAGCCCTCCTAACTCCATAG

Upstream 100 bases:

>100_bases
AAAGTTGCAGCACGAATAACTATTTTCTCCATAAATCCACCCTGCTATCTTTAAATACGTTCCTCCTATTTAAGAAAACG
GTGTAAACAGGTGGGTAGTC

Downstream 100 bases:

>100_bases
AGATTATCCCACTAAGGTTTTTTACTACATTCTATCATACCGTTACTAGTCAGGACCATGATAGATGGGTGCTGTGAATG
AGTGTTAATGAAGCCGTGTC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MVTSLKGRHFLTLAEYSREELLFMIRTAMQFKQRYLAGERIIPLLVGRHLAMIFEKPSTRTRISFETAMKELGGDAIYLS
ASELQLARGETIEDTARVLSRYVDVIMARVYEHYKIEKLAQYSRVPVINGLSDLHHPAQALSDVLTIMEKKGGDITRLKI
VFVGDGGDNVLHSLMLATGILGGKIIIASPKGYEPHPSVVKLFNEHASPNGGSYEIERDPFKAVENADVVYTDVWVSMGQ
EKEKEKRIKDLEPYRVTVELMNHAKPDAIFMHCLPAHRGEEVVNEVIDGKWSVVWDQAENRKHAQKAILALLTP

Sequences:

>Translated_314_residues
MVTSLKGRHFLTLAEYSREELLFMIRTAMQFKQRYLAGERIIPLLVGRHLAMIFEKPSTRTRISFETAMKELGGDAIYLS
ASELQLARGETIEDTARVLSRYVDVIMARVYEHYKIEKLAQYSRVPVINGLSDLHHPAQALSDVLTIMEKKGGDITRLKI
VFVGDGGDNVLHSLMLATGILGGKIIIASPKGYEPHPSVVKLFNEHASPNGGSYEIERDPFKAVENADVVYTDVWVSMGQ
EKEKEKRIKDLEPYRVTVELMNHAKPDAIFMHCLPAHRGEEVVNEVIDGKWSVVWDQAENRKHAQKAILALLTP
>Mature_314_residues
MVTSLKGRHFLTLAEYSREELLFMIRTAMQFKQRYLAGERIIPLLVGRHLAMIFEKPSTRTRISFETAMKELGGDAIYLS
ASELQLARGETIEDTARVLSRYVDVIMARVYEHYKIEKLAQYSRVPVINGLSDLHHPAQALSDVLTIMEKKGGDITRLKI
VFVGDGGDNVLHSLMLATGILGGKIIIASPKGYEPHPSVVKLFNEHASPNGGSYEIERDPFKAVENADVVYTDVWVSMGQ
EKEKEKRIKDLEPYRVTVELMNHAKPDAIFMHCLPAHRGEEVVNEVIDGKWSVVWDQAENRKHAQKAILALLTP

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=310, Percent_Identity=42.5806451612903, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI18105007, Length=316, Percent_Identity=27.2151898734177, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1790703, Length=323, Percent_Identity=38.390092879257, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1786469, Length=329, Percent_Identity=37.0820668693009, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI2367364, Length=324, Percent_Identity=27.1604938271605, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994908, Length=323, Percent_Identity=26.0061919504644, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=172, Percent_Identity=32.5581395348837, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=310, Percent_Identity=36.1290322580645, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322331, Length=313, Percent_Identity=30.3514376996805, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24642586, Length=318, Percent_Identity=28.3018867924528, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 35406; Mature: 35406

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSLKGRHFLTLAEYSREELLFMIRTAMQFKQRYLAGERIIPLLVGRHLAMIFEKPSTR
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
TRISFETAMKELGGDAIYLSASELQLARGETIEDTARVLSRYVDVIMARVYEHYKIEKLA
EEEEHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYSRVPVINGLSDLHHPAQALSDVLTIMEKKGGDITRLKIVFVGDGGDNVLHSLMLATGI
HHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHC
LGGKIIIASPKGYEPHPSVVKLFNEHASPNGGSYEIERDPFKAVENADVVYTDVWVSMGQ
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHHHHHCCCCEEEEHHHHHCCC
EKEKEKRIKDLEPYRVTVELMNHAKPDAIFMHCLPAHRGEEVVNEVIDGKWSVVWDQAEN
HHHHHHHHHCCCCCEEHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCC
RKHAQKAILALLTP
HHHHHHHHHHHCCC
>Mature Secondary Structure
MVTSLKGRHFLTLAEYSREELLFMIRTAMQFKQRYLAGERIIPLLVGRHLAMIFEKPSTR
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
TRISFETAMKELGGDAIYLSASELQLARGETIEDTARVLSRYVDVIMARVYEHYKIEKLA
EEEEHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QYSRVPVINGLSDLHHPAQALSDVLTIMEKKGGDITRLKIVFVGDGGDNVLHSLMLATGI
HHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHC
LGGKIIIASPKGYEPHPSVVKLFNEHASPNGGSYEIERDPFKAVENADVVYTDVWVSMGQ
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHHHHHCCCCEEEEHHHHHCCC
EKEKEKRIKDLEPYRVTVELMNHAKPDAIFMHCLPAHRGEEVVNEVIDGKWSVVWDQAEN
HHHHHHHHHCCCCCEEHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCC
RKHAQKAILALLTP
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA