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The map label for this gene is mvk [H]

Identifier: 218883445

GI number: 218883445

Start: 119401

End: 120351

Strand: Reverse

Name: mvk [H]

Synonym: DKAM_0131

Alternate gene names: 218883445

Gene position: 120351-119401 (Counterclockwise)

Preceding gene: 218883447

Following gene: 218883444

Centisome position: 8.82

GC content: 47.0

Gene sequence:

>951_bases
ATGACCTGTAGTATAGCACCTGGCAAGATCATCTTATTCGGCGAGCACTTCGTTGTAGAAGGCTATCCAGCGATCGGCCT
AGCTGTGGGGCTCTACGCTAGAACATGCGTTGAGGAAGGGGATTTAAAAATCTACTCTAGGCAACTGGGGCCAATAGATC
CCTCCTCCAAGGAGGCGAAACCATATATGAGGATCATTGAGGAGGCAAGTATAAGATATGGTTGCAGAGACAGGTATAGG
ATATATATAGACTCCGAAATACCCGTTGGAGCTGGAATGGGTTCTTCAGCAGCTGTAAACGTCTCCCTAGCTCACTCCCT
ACTGGAAACATGTGGCGTGGAGTTCACTAAGGAGGATGTCAGTAGAATAGCCTACCTGGGGGAAACCATGGTCCATGGTA
AGCCAAGTGGCGTAGATAACACGTTATCCACTTACGGTGGACTCGTATACTACAGGCAGGGCTTATTCAAGCGCCTTAAC
ACATCTTTACCAGAGAATACAGCACTAATAGTAGCTGACACAGGTGTTAAAAGGGATACAGGCCTAGTGGTTAGAGAAGT
ATTAGAGAGATATAGGAGACTAGGAGGGCTTGGCAAGGCGATTTATGAAGTAGCTGGCAGACTAGTCGAAGAAGCAGCAG
TAGCCATCGAGAAAGGCGACGTAAGTAGGCTGGGTGAATTAATGATCGTTAACCATGGATTACTCTTCGCGATGGGTGCC
TCAGCCTGGATAAACGACTACCTTGTCTACAAAATGATTAACAATGGTGCTCAAGGAGCAAAGCTGAGTGGTGCTGGGAG
GGGGGGTATAGTTATAGGGATAGCAAGACTGGAGAACACTGGTAAAATAATGGAGGCACTGAAGACCGAGAAGGTTAACG
CATACCTGGTTAAACCGGATTATGATGGTGTCCGCTCAATAAATACTAGGGTTTCCCCCATGAAGCATTAA

Upstream 100 bases:

>100_bases
CGTTTCTCCCCGCTACTACTCATTAACATGCACCATGGCAATCATTTATAACCATGTTATCTCACTATACTCTTAAATAG
TTTAAGGGTGCGTAGAGTAA

Downstream 100 bases:

>100_bases
ATAAAGCCGATGTCATTATTTAAATGAGAATGATGAATATAGTGGTCTATGAGACGTGATTAGACTCCCATGGGCTGACC
CCTATGATGGATGAGAATAA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTCSIAPGKIILFGEHFVVEGYPAIGLAVGLYARTCVEEGDLKIYSRQLGPIDPSSKEAKPYMRIIEEASIRYGCRDRYR
IYIDSEIPVGAGMGSSAAVNVSLAHSLLETCGVEFTKEDVSRIAYLGETMVHGKPSGVDNTLSTYGGLVYYRQGLFKRLN
TSLPENTALIVADTGVKRDTGLVVREVLERYRRLGGLGKAIYEVAGRLVEEAAVAIEKGDVSRLGELMIVNHGLLFAMGA
SAWINDYLVYKMINNGAQGAKLSGAGRGGIVIGIARLENTGKIMEALKTEKVNAYLVKPDYDGVRSINTRVSPMKH

Sequences:

>Translated_316_residues
MTCSIAPGKIILFGEHFVVEGYPAIGLAVGLYARTCVEEGDLKIYSRQLGPIDPSSKEAKPYMRIIEEASIRYGCRDRYR
IYIDSEIPVGAGMGSSAAVNVSLAHSLLETCGVEFTKEDVSRIAYLGETMVHGKPSGVDNTLSTYGGLVYYRQGLFKRLN
TSLPENTALIVADTGVKRDTGLVVREVLERYRRLGGLGKAIYEVAGRLVEEAAVAIEKGDVSRLGELMIVNHGLLFAMGA
SAWINDYLVYKMINNGAQGAKLSGAGRGGIVIGIARLENTGKIMEALKTEKVNAYLVKPDYDGVRSINTRVSPMKH
>Mature_315_residues
TCSIAPGKIILFGEHFVVEGYPAIGLAVGLYARTCVEEGDLKIYSRQLGPIDPSSKEAKPYMRIIEEASIRYGCRDRYRI
YIDSEIPVGAGMGSSAAVNVSLAHSLLETCGVEFTKEDVSRIAYLGETMVHGKPSGVDNTLSTYGGLVYYRQGLFKRLNT
SLPENTALIVADTGVKRDTGLVVREVLERYRRLGGLGKAIYEVAGRLVEEAAVAIEKGDVSRLGELMIVNHGLLFAMGAS
AWINDYLVYKMINNGAQGAKLSGAGRGGIVIGIARLENTGKIMEALKTEKVNAYLVKPDYDGVRSINTRVSPMKH

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=241, Percent_Identity=32.3651452282158, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557769, Length=241, Percent_Identity=32.3651452282158, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323864, Length=248, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707210, Length=211, Percent_Identity=33.6492890995261, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34287; Mature: 34156

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCSIAPGKIILFGEHFVVEGYPAIGLAVGLYARTCVEEGDLKIYSRQLGPIDPSSKEAK
CCCCCCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCH
PYMRIIEEASIRYGCRDRYRIYIDSEIPVGAGMGSSAAVNVSLAHSLLETCGVEFTKEDV
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHH
SRIAYLGETMVHGKPSGVDNTLSTYGGLVYYRQGLFKRLNTSLPENTALIVADTGVKRDT
HHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
GLVVREVLERYRRLGGLGKAIYEVAGRLVEEAAVAIEKGDVSRLGELMIVNHGLLFAMGA
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCHHEEECC
SAWINDYLVYKMINNGAQGAKLSGAGRGGIVIGIARLENTGKIMEALKTEKVNAYLVKPD
HHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEEECCHHHHHHHHHHCCCEEEEECCC
YDGVRSINTRVSPMKH
CCCHHHHCCCCCCCCC
>Mature Secondary Structure 
TCSIAPGKIILFGEHFVVEGYPAIGLAVGLYARTCVEEGDLKIYSRQLGPIDPSSKEAK
CCCCCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCH
PYMRIIEEASIRYGCRDRYRIYIDSEIPVGAGMGSSAAVNVSLAHSLLETCGVEFTKEDV
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHH
SRIAYLGETMVHGKPSGVDNTLSTYGGLVYYRQGLFKRLNTSLPENTALIVADTGVKRDT
HHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
GLVVREVLERYRRLGGLGKAIYEVAGRLVEEAAVAIEKGDVSRLGELMIVNHGLLFAMGA
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCHHEEECC
SAWINDYLVYKMINNGAQGAKLSGAGRGGIVIGIARLENTGKIMEALKTEKVNAYLVKPD
HHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEEEECCHHHHHHHHHHCCCEEEEECCC
YDGVRSINTRVSPMKH
CCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]