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The map label for this gene is dhaT [H]

Identifier: 218883441

GI number: 218883441

Start: 115308

End: 116486

Strand: Reverse

Name: dhaT [H]

Synonym: DKAM_0127

Alternate gene names: 218883441

Gene position: 116486-115308 (Counterclockwise)

Preceding gene: 218883442

Following gene: 218883439

Centisome position: 8.53

GC content: 44.02

Gene sequence:

>1179_bases
GTGGATAAAATGAGATATTATAGTCAAACATATAGATTCAGATATAATGATGCATGCTTATTCTTTGGTAGCGGTGTTCT
CCGTGAGAAACTCGGAGAAAACGTGAAAAACCATAGAAAGGCATTACTCATCACCAGTAAAAATGCAGCAAAGGTTTCAG
GAGCACTCGACACAGTGGTTGAAGCCTTGAAGAGAGAGAACATAGAGTATTTCATTTATGATGGGGTCAAAGCGAATCCT
TATACAAGTATGGCTGACGAAGCTGGTAGAATAGCTGCCGAGAACAGGGTTGACTTGGTAATAGCTATAGGTGGGGGCAG
CGTAATAGATACTGCTAAATTCGCCTCGATAATTGCCACTACAGGCTTTAAGGCTGTAGAAATCCTGACAAATCCATCCC
TGTCATCGAATGTCACGCGCTTACCACTGATAGCCGTGAACCTCACCCATGGAACAGGCAGCGAGATAGATAGATACGCC
GTATTAACAATCGATGGAACCATTGAGAAAAGAGGGGTAGCCGTGAGATACCCGGATGTAAGTTTCGACGACCCGCTTTA
CAGCAGGACCCTCAGTAAGGATCAAACAATATATACAAGCCTGGATGCATTCTATCATTCATATGAGGCAGCTACATCAG
CATTCTCCAACTTACTATCAATAACTCTCTCCAAGGAGGCTATAGAGATAATCGCGGAAACCCTGCCTAAAATACTTGGA
GACCTAGATAACATAGAGTACAGGACCAAACTACTATATGCATCGATGATAGCCGGCATAGCTATCGATCAATCAATGAC
TCATTTAAACCACGCTCTTGAACACGCTTTCAGTGGATTACACCCGGAGCTACCCCATGGGGCAGGTCTCGCCATACTGG
GACCCATGGTCGTATACTACACGCATAAAGCTGTCCCTGAGGTCTCAGCTCAACTATTAAAACCATTGGATCCGGGAATT
AAACCGGTGAGTGAGGATGCCGAGAAGGCATATAAAGCCGTCAGAGACTTCCAGTCATCAGTAGGCCTCGATAAGAGGTT
AAGTGATTATGGAATAGATAGGAGGGATGTTGAGAAAGCAATAGAGTTCGCCGTGAGAATGATCAACACGCGGTATACGT
CTATACCATTTAAACCCAGTAGCGATGTCTTAAGAGATATAATTGAGAAATCCCTCTAA

Upstream 100 bases:

>100_bases
TTCATAGAGGCTTCATCAAGGATTTATGGATTAATCGAGGTAAGCGATTTCATAGTAATAGATAAAAACTAGGACAATTA
TAGTAGAACCTATCTATAGG

Downstream 100 bases:

>100_bases
TCTCCTGAGGCATCTAGATACCGTAGTTTTATCTTGCCTGCAAACGATGCCAATTTCTTCAGCATATATTCCCTCTCCTT
ATTCCCCGTTTTTAAATCGC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDKMRYYSQTYRFRYNDACLFFGSGVLREKLGENVKNHRKALLITSKNAAKVSGALDTVVEALKRENIEYFIYDGVKANP
YTSMADEAGRIAAENRVDLVIAIGGGSVIDTAKFASIIATTGFKAVEILTNPSLSSNVTRLPLIAVNLTHGTGSEIDRYA
VLTIDGTIEKRGVAVRYPDVSFDDPLYSRTLSKDQTIYTSLDAFYHSYEAATSAFSNLLSITLSKEAIEIIAETLPKILG
DLDNIEYRTKLLYASMIAGIAIDQSMTHLNHALEHAFSGLHPELPHGAGLAILGPMVVYYTHKAVPEVSAQLLKPLDPGI
KPVSEDAEKAYKAVRDFQSSVGLDKRLSDYGIDRRDVEKAIEFAVRMINTRYTSIPFKPSSDVLRDIIEKSL

Sequences:

>Translated_392_residues
MDKMRYYSQTYRFRYNDACLFFGSGVLREKLGENVKNHRKALLITSKNAAKVSGALDTVVEALKRENIEYFIYDGVKANP
YTSMADEAGRIAAENRVDLVIAIGGGSVIDTAKFASIIATTGFKAVEILTNPSLSSNVTRLPLIAVNLTHGTGSEIDRYA
VLTIDGTIEKRGVAVRYPDVSFDDPLYSRTLSKDQTIYTSLDAFYHSYEAATSAFSNLLSITLSKEAIEIIAETLPKILG
DLDNIEYRTKLLYASMIAGIAIDQSMTHLNHALEHAFSGLHPELPHGAGLAILGPMVVYYTHKAVPEVSAQLLKPLDPGI
KPVSEDAEKAYKAVRDFQSSVGLDKRLSDYGIDRRDVEKAIEFAVRMINTRYTSIPFKPSSDVLRDIIEKSL
>Mature_392_residues
MDKMRYYSQTYRFRYNDACLFFGSGVLREKLGENVKNHRKALLITSKNAAKVSGALDTVVEALKRENIEYFIYDGVKANP
YTSMADEAGRIAAENRVDLVIAIGGGSVIDTAKFASIIATTGFKAVEILTNPSLSSNVTRLPLIAVNLTHGTGSEIDRYA
VLTIDGTIEKRGVAVRYPDVSFDDPLYSRTLSKDQTIYTSLDAFYHSYEAATSAFSNLLSITLSKEAIEIIAETLPKILG
DLDNIEYRTKLLYASMIAGIAIDQSMTHLNHALEHAFSGLHPELPHGAGLAILGPMVVYYTHKAVPEVSAQLLKPLDPGI
KPVSEDAEKAYKAVRDFQSSVGLDKRLSDYGIDRRDVEKAIEFAVRMINTRYTSIPFKPSSDVLRDIIEKSL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=336, Percent_Identity=26.7857142857143, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI48994951, Length=351, Percent_Identity=29.3447293447293, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082107, Length=262, Percent_Identity=32.4427480916031, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789163, Length=378, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787493, Length=301, Percent_Identity=27.906976744186, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=26.536312849162, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=29.03981264637, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321181, Length=380, Percent_Identity=28.1578947368421, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24657991, Length=428, Percent_Identity=26.8691588785047, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 43260; Mature: 43260

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKMRYYSQTYRFRYNDACLFFGSGVLREKLGENVKNHRKALLITSKNAAKVSGALDTVV
CCCHHHHHHHHEEEECCEEEEECCHHHHHHHHCHHHHCCEEEEEECCCCHHHHHHHHHHH
EALKRENIEYFIYDGVKANPYTSMADEAGRIAAENRVDLVIAIGGGSVIDTAKFASIIAT
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCEEECCCEEEEEEECCCCHHHHHHHHHHHHH
TGFKAVEILTNPSLSSNVTRLPLIAVNLTHGTGSEIDRYAVLTIDGTIEKRGVAVRYPDV
CCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEECCCC
SFDDPLYSRTLSKDQTIYTSLDAFYHSYEAATSAFSNLLSITLSKEAIEIIAETLPKILG
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLDNIEYRTKLLYASMIAGIAIDQSMTHLNHALEHAFSGLHPELPHGAGLAILGPMVVYY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
THKAVPEVSAQLLKPLDPGIKPVSEDAEKAYKAVRDFQSSVGLDKRLSDYGIDRRDVEKA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
IEFAVRMINTRYTSIPFKPSSDVLRDIIEKSL
HHHHHHHHHHHEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDKMRYYSQTYRFRYNDACLFFGSGVLREKLGENVKNHRKALLITSKNAAKVSGALDTVV
CCCHHHHHHHHEEEECCEEEEECCHHHHHHHHCHHHHCCEEEEEECCCCHHHHHHHHHHH
EALKRENIEYFIYDGVKANPYTSMADEAGRIAAENRVDLVIAIGGGSVIDTAKFASIIAT
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCEEECCCEEEEEEECCCCHHHHHHHHHHHHH
TGFKAVEILTNPSLSSNVTRLPLIAVNLTHGTGSEIDRYAVLTIDGTIEKRGVAVRYPDV
CCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEECCCC
SFDDPLYSRTLSKDQTIYTSLDAFYHSYEAATSAFSNLLSITLSKEAIEIIAETLPKILG
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLDNIEYRTKLLYASMIAGIAIDQSMTHLNHALEHAFSGLHPELPHGAGLAILGPMVVYY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
THKAVPEVSAQLLKPLDPGIKPVSEDAEKAYKAVRDFQSSVGLDKRLSDYGIDRRDVEKA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
IEFAVRMINTRYTSIPFKPSSDVLRDIIEKSL
HHHHHHHHHHHEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]