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The map label for this gene is rnhB [H]

Identifier: 218883330

GI number: 218883330

Start: 12997

End: 13764

Strand: Reverse

Name: rnhB [H]

Synonym: DKAM_0016

Alternate gene names: 218883330

Gene position: 13764-12997 (Counterclockwise)

Preceding gene: 218883332

Following gene: 218883329

Centisome position: 1.01

GC content: 43.49

Gene sequence:

>768_bases
GTGGGTAAGCCTGAGATTATAGAAATAGGTGTTGATGAAGCCGGAAGAGGACCATTTATAGGGGACATGGTGATAGCTGG
TGTAATTGGTTTAAGTAGCGCGTTTGAATCGCTGGTTTCTATAGGATTAAGGGATAGCAAGCTCCTCGAACCCTTGAAGA
GACTTATGATATTAAATAACATGCTCTCACTGGACATAGATATTGTTGCAACCTATGTAAGCCCTATCCACATAGACAGA
AGTAACATGAATATGCTTGAATACACCGTGATATGTAGTATCCTCAAGTATCTATCCTACAGCCATATCCTAAGACAACA
CCAGGGTACCGGGGTAAGGATATATATTGATGAAGTGAAGGGCTACAATGATAAAATAGGGGAATGTGCTAGAGGACTGT
ACAGGGGTAATGTAGAAATATTCATTGAATCCAGGGCAGACGCGAAATACCCGGCTGTTTCTGCTGCAAGCGTAGTAGCG
AAAATACTCAGGGACAGTAATATTAAGGCACTACAAGTAATAGCGGGTGAAACGGGCTCCGGATACCCTAGCGATCCAGT
CTCTAGGAGATGGCTTGCTAATATGTATAGAGATGATGGCGAACCCCCTGTATACATCAGGAAAAGTTGGGGCATAGTGA
AGGATCTAGCCCCCAGCTGGTACGTTAGTAAACAAGTGAAGCATGGTAAAAAGGAGGGATCCTTACTAGACTATATTAGA
AGGGGAGTAACCTATGGTAACCAACCTACCAGCGGAAGCAAAGGCTAA

Upstream 100 bases:

>100_bases
TACTGGGAGCCACTTAATCTAAAAAATTAATTAAATATTAAGAGGATGGGGAATAATTAAAATCTCTTAAAGAGGATACA
GCAGATAATGGGAAGGAGTA

Downstream 100 bases:

>100_bases
ATGGCTAAAGGTAATGGAGGCTAAAACACCAGAGGAAAAGATGAAGGCACTAGAGGACTTCTTATCCAGTGTGCCCAAGC
ATAAGGGCACAGAGAAACTA

Product: Ribonuclease HII

Products: NA

Alternate protein names: RNase HII [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MGKPEIIEIGVDEAGRGPFIGDMVIAGVIGLSSAFESLVSIGLRDSKLLEPLKRLMILNNMLSLDIDIVATYVSPIHIDR
SNMNMLEYTVICSILKYLSYSHILRQHQGTGVRIYIDEVKGYNDKIGECARGLYRGNVEIFIESRADAKYPAVSAASVVA
KILRDSNIKALQVIAGETGSGYPSDPVSRRWLANMYRDDGEPPVYIRKSWGIVKDLAPSWYVSKQVKHGKKEGSLLDYIR
RGVTYGNQPTSGSKG

Sequences:

>Translated_255_residues
MGKPEIIEIGVDEAGRGPFIGDMVIAGVIGLSSAFESLVSIGLRDSKLLEPLKRLMILNNMLSLDIDIVATYVSPIHIDR
SNMNMLEYTVICSILKYLSYSHILRQHQGTGVRIYIDEVKGYNDKIGECARGLYRGNVEIFIESRADAKYPAVSAASVVA
KILRDSNIKALQVIAGETGSGYPSDPVSRRWLANMYRDDGEPPVYIRKSWGIVKDLAPSWYVSKQVKHGKKEGSLLDYIR
RGVTYGNQPTSGSKG
>Mature_254_residues
GKPEIIEIGVDEAGRGPFIGDMVIAGVIGLSSAFESLVSIGLRDSKLLEPLKRLMILNNMLSLDIDIVATYVSPIHIDRS
NMNMLEYTVICSILKYLSYSHILRQHQGTGVRIYIDEVKGYNDKIGECARGLYRGNVEIFIESRADAKYPAVSAASVVAK
ILRDSNIKALQVIAGETGSGYPSDPVSRRWLANMYRDDGEPPVYIRKSWGIVKDLAPSWYVSKQVKHGKKEGSLLDYIRR
GVTYGNQPTSGSKG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0164

COG function: function code L; Ribonuclease HII

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase HII family [H]

Homologues:

Organism=Homo sapiens, GI38455391, Length=224, Percent_Identity=30.8035714285714, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17536263, Length=206, Percent_Identity=31.5533980582524, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24580635, Length=224, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004649
- InterPro:   IPR001352
- InterPro:   IPR020787
- InterPro:   IPR023160
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01351 RNase_HII [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 28157; Mature: 28026

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKPEIIEIGVDEAGRGPFIGDMVIAGVIGLSSAFESLVSIGLRDSKLLEPLKRLMILNN
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MLSLDIDIVATYVSPIHIDRSNMNMLEYTVICSILKYLSYSHILRQHQGTGVRIYIDEVK
HHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GYNDKIGECARGLYRGNVEIFIESRADAKYPAVSAASVVAKILRDSNIKALQVIAGETGS
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
GYPSDPVSRRWLANMYRDDGEPPVYIRKSWGIVKDLAPSWYVSKQVKHGKKEGSLLDYIR
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHH
RGVTYGNQPTSGSKG
HCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKPEIIEIGVDEAGRGPFIGDMVIAGVIGLSSAFESLVSIGLRDSKLLEPLKRLMILNN
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MLSLDIDIVATYVSPIHIDRSNMNMLEYTVICSILKYLSYSHILRQHQGTGVRIYIDEVK
HHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GYNDKIGECARGLYRGNVEIFIESRADAKYPAVSAASVVAKILRDSNIKALQVIAGETGS
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
GYPSDPVSRRWLANMYRDDGEPPVYIRKSWGIVKDLAPSWYVSKQVKHGKKEGSLLDYIR
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHH
RGVTYGNQPTSGSKG
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA