Click here to switch to the map view.

The map label for this gene is atpA [H]

Identifier: 218711025

GI number: 218711025

Start: 3290640

End: 3292211

Strand: Reverse

Name: atpA [H]

Synonym: VS_3154

Alternate gene names: 218711025

Gene position: 3292211-3290640 (Counterclockwise)

Preceding gene: 218711026

Following gene: 218711024

Centisome position: 99.79

GC content: 45.93

Gene sequence:

>1572_bases
ATGCATTGCAGTCTTAATGGGGATTGGAGCATGCAACTTAATTCCACTGAAATTAGCGATCTAATTAAACAACGTATTGA
ATCTTTCGACGTTGTTAGTGAAGCTCGCAATGAAGGTACTATCGTTTCTGTAAGCGATGGCATCCTTAGCATCCACGGCC
TAGCGGACGTGATGCAAGGTGAAATGATCGAACTACCGGGTGGCCGTTACGCGCTAGCACTAAACTTGAACCGTGATTCG
GTTGGTGCTGTTGTAATGGGCCCGTATGCTGACCTACAGGAAGGCATGAAAGTTACAGGTACTGGTCGTATTCTAGAAGT
ACCAGTAGGTCCTGAAATGCTTGGTCGTGTTGTAAACACACTAGGTGAGCCAATTGATGGTAAAGGTCCAATCGAAGCTA
AATTGACTTCGCCTGTAGAAATTATCGCACCAGGTGTAATCGACCGTAAATCGGTAGATCAACCTGTTCAAACTGGTTAC
AAGTCTGTTGACTCAATGATCCCTATCGGTCGTGGTCAACGTGAACTAGTAATCGGTGACCGTCAGACTGGTAAAACAGC
AATGGCGATCGATGCGATTATTAACCAAAAAGATTCTGGTATTTTCTCTATCTATGTAGCTATCGGCCAAAAAGCGTCGA
CTATTGCTAACGTAGTTCGCAAACTAGAAGAGCACGGCGCACTAGCCAACACTGTTGTTGTTGTTGCATCGGCTTCTGAA
TCTGCAGCGCTGCAATACCTTGCACCGTATGCTGGTTGTGCGATGGGCGAATACTTCCGTGATCGCGGTGAAGATGCACT
GATTGTTTATGATGATCTATCTAAGCAAGCTGTCGCTTACCGTCAAATCTCGCTACTACTTAAGCGTCCACCAGGTCGTG
AAGCGTTCCCAGGTGATGTTTTCTACCTTCACTCTCGTCTACTAGAGCGTGCAGCTCGTGTAAGCGAAGCATACGTAGAA
AAATTCACTAACGGTGAAGTGACAGGCAAGACTGGTTCTTTAACAGCTCTTCCTATCATCGAAACGCAAGCTGGTGACGT
ATCTGCATTCGTACCAACGAACGTAATCTCGATTACTGATGGTCAGATCTTCCTACAAACTGAGCTATTCAACGCGGGCG
TACGTCCAGCTGTTGACCCAGGTATCTCAGTTTCTCGTGTAGGTGGTTCGGCGCAGACTAAAATCATCAAGAAGCTATCT
GGCGGTATCCGTACTGCTCTAGCTCAATACCGTGAACTTGCAGCATTTGCTCAGTTTTCTTCGGATCTTGATGAAGCGAC
TAAGAAGCAGCTAGACCACGGTCAAAAAGTTACAGAACTGATGAAGCAGAAGCAATACGCTCCTATGTCTGTATTTGACC
AAGCTCTAGTAATCTTCGCTGCAGAGCGTGGATACCTTCAAGACGTTGAACTTTCTAAAGTTCTAGACTTTGAAGCTGCT
TTACTGTCGTTTGCTCGTGGTCAATACGCTGATCTAGTAACACAGATCGACGCAACGGGTGCTTTCAACAAAGAAATCGA
AGCTGAGCTGAAGAAGCTTGTTGACGATTTCAAGGCAACCCAGACCTGGTAA

Upstream 100 bases:

>100_bases
AATTGCAGTATAGATGAGACTCTACTTAGTGGAGTTATTATTCGAGCCGGAGACCTAGTCATCGATAACTCAGCGCGCAG
TCGTTTAGACCGCCTGAGCG

Downstream 100 bases:

>100_bases
TTGGTAGGTGGTCTTAGGGCCACCTCATACCATTAACGGAGAGTAACGATGGCCGGCGCAAAAGAGATACGTAATAAAAT
CGGTAGTGTTAAAAGCACAC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MHCSLNGDWSMQLNSTEISDLIKQRIESFDVVSEARNEGTIVSVSDGILSIHGLADVMQGEMIELPGGRYALALNLNRDS
VGAVVMGPYADLQEGMKVTGTGRILEVPVGPEMLGRVVNTLGEPIDGKGPIEAKLTSPVEIIAPGVIDRKSVDQPVQTGY
KSVDSMIPIGRGQRELVIGDRQTGKTAMAIDAIINQKDSGIFSIYVAIGQKASTIANVVRKLEEHGALANTVVVVASASE
SAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAFPGDVFYLHSRLLERAARVSEAYVE
KFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLQTELFNAGVRPAVDPGISVSRVGGSAQTKIIKKLS
GGIRTALAQYRELAAFAQFSSDLDEATKKQLDHGQKVTELMKQKQYAPMSVFDQALVIFAAERGYLQDVELSKVLDFEAA
LLSFARGQYADLVTQIDATGAFNKEIEAELKKLVDDFKATQTW

Sequences:

>Translated_523_residues
MHCSLNGDWSMQLNSTEISDLIKQRIESFDVVSEARNEGTIVSVSDGILSIHGLADVMQGEMIELPGGRYALALNLNRDS
VGAVVMGPYADLQEGMKVTGTGRILEVPVGPEMLGRVVNTLGEPIDGKGPIEAKLTSPVEIIAPGVIDRKSVDQPVQTGY
KSVDSMIPIGRGQRELVIGDRQTGKTAMAIDAIINQKDSGIFSIYVAIGQKASTIANVVRKLEEHGALANTVVVVASASE
SAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAFPGDVFYLHSRLLERAARVSEAYVE
KFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLQTELFNAGVRPAVDPGISVSRVGGSAQTKIIKKLS
GGIRTALAQYRELAAFAQFSSDLDEATKKQLDHGQKVTELMKQKQYAPMSVFDQALVIFAAERGYLQDVELSKVLDFEAA
LLSFARGQYADLVTQIDATGAFNKEIEAELKKLVDDFKATQTW
>Mature_523_residues
MHCSLNGDWSMQLNSTEISDLIKQRIESFDVVSEARNEGTIVSVSDGILSIHGLADVMQGEMIELPGGRYALALNLNRDS
VGAVVMGPYADLQEGMKVTGTGRILEVPVGPEMLGRVVNTLGEPIDGKGPIEAKLTSPVEIIAPGVIDRKSVDQPVQTGY
KSVDSMIPIGRGQRELVIGDRQTGKTAMAIDAIINQKDSGIFSIYVAIGQKASTIANVVRKLEEHGALANTVVVVASASE
SAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAFPGDVFYLHSRLLERAARVSEAYVE
KFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLQTELFNAGVRPAVDPGISVSRVGGSAQTKIIKKLS
GGIRTALAQYRELAAFAQFSSDLDEATKKQLDHGQKVTELMKQKQYAPMSVFDQALVIFAAERGYLQDVELSKVLDFEAA
LLSFARGQYADLVTQIDATGAFNKEIEAELKKLVDDFKATQTW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=513, Percent_Identity=55.3606237816764, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI4757810, Length=513, Percent_Identity=55.3606237816764, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI32189394, Length=427, Percent_Identity=25.7611241217799, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI19913426, Length=308, Percent_Identity=28.2467532467532, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI19913428, Length=308, Percent_Identity=27.9220779220779, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI19913424, Length=338, Percent_Identity=24.5562130177515, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=82.6510721247563, Blast_Score=871, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=394, Percent_Identity=25.1269035532995, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788251, Length=384, Percent_Identity=25.2604166666667, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=515, Percent_Identity=54.5631067961165, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71988080, Length=515, Percent_Identity=54.5631067961165, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71988074, Length=515, Percent_Identity=51.4563106796116, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25144756, Length=384, Percent_Identity=25.5208333333333, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=370, Percent_Identity=26.4864864864865, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=314, Percent_Identity=27.7070063694268, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17509265, Length=47, Percent_Identity=61.7021276595745, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=519, Percent_Identity=51.6377649325626, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322581, Length=435, Percent_Identity=26.8965517241379, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319603, Length=359, Percent_Identity=27.0194986072423, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=514, Percent_Identity=54.6692607003891, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24638766, Length=387, Percent_Identity=26.3565891472868, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.2131147540984, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.2131147540984, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.2131147540984, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574560, Length=321, Percent_Identity=25.8566978193146, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24583992, Length=334, Percent_Identity=24.8502994011976, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583988, Length=263, Percent_Identity=26.9961977186312, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583986, Length=263, Percent_Identity=26.9961977186312, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583984, Length=263, Percent_Identity=26.9961977186312, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 56441; Mature: 56441

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCSLNGDWSMQLNSTEISDLIKQRIESFDVVSEARNEGTIVSVSDGILSIHGLADVMQG
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHCC
EMIELPGGRYALALNLNRDSVGAVVMGPYADLQEGMKVTGTGRILEVPVGPEMLGRVVNT
CEEECCCCCEEEEEECCCCCCCEEEECCHHHHHCCCEEECCCEEEECCCCHHHHHHHHHH
LGEPIDGKGPIEAKLTSPVEIIAPGVIDRKSVDQPVQTGYKSVDSMIPIGRGQRELVIGD
HCCCCCCCCCCCEECCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECC
RQTGKTAMAIDAIINQKDSGIFSIYVAIGQKASTIANVVRKLEEHGALANTVVVVASASE
CCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCC
SAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAFPGDV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAARVSEAYVEKFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITD
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCCCEEEECCCCEEEEEC
GQIFLQTELFNAGVRPAVDPGISVSRVGGSAQTKIIKKLSGGIRTALAQYRELAAFAQFS
CEEEEEEEHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDLDEATKKQLDHGQKVTELMKQKQYAPMSVFDQALVIFAAERGYLQDVELSKVLDFEAA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
LLSFARGQYADLVTQIDATGAFNKEIEAELKKLVDDFKATQTW
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHCSLNGDWSMQLNSTEISDLIKQRIESFDVVSEARNEGTIVSVSDGILSIHGLADVMQG
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHCC
EMIELPGGRYALALNLNRDSVGAVVMGPYADLQEGMKVTGTGRILEVPVGPEMLGRVVNT
CEEECCCCCEEEEEECCCCCCCEEEECCHHHHHCCCEEECCCEEEECCCCHHHHHHHHHH
LGEPIDGKGPIEAKLTSPVEIIAPGVIDRKSVDQPVQTGYKSVDSMIPIGRGQRELVIGD
HCCCCCCCCCCCEECCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECC
RQTGKTAMAIDAIINQKDSGIFSIYVAIGQKASTIANVVRKLEEHGALANTVVVVASASE
CCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCC
SAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAFPGDV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAARVSEAYVEKFTNGEVTGKTGSLTALPIIETQAGDVSAFVPTNVISITD
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCCCEEEECCCCEEEEEC
GQIFLQTELFNAGVRPAVDPGISVSRVGGSAQTKIIKKLSGGIRTALAQYRELAAFAQFS
CEEEEEEEHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDLDEATKKQLDHGQKVTELMKQKQYAPMSVFDQALVIFAAERGYLQDVELSKVLDFEAA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
LLSFARGQYADLVTQIDATGAFNKEIEAELKKLVDDFKATQTW
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]