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The map label for this gene is glmU [H]

Identifier: 218711021

GI number: 218711021

Start: 3286302

End: 3287678

Strand: Reverse

Name: glmU [H]

Synonym: VS_3150

Alternate gene names: 218711021

Gene position: 3287678-3286302 (Counterclockwise)

Preceding gene: 218711022

Following gene: 218711019

Centisome position: 99.65

GC content: 48.29

Gene sequence:

>1377_bases
TTGGATAGGTTTACAATGAAGTTTAGCGCAGTGATTCTCGCGGCGGGCAAAGGCACTCGCATGTATTCAAACACACCAAA
GGTTCTGCACACGCTTGCGGGTAAGCCGATGGTTAAACATGTTATTGATACTTGTAACGGCTTAGGCGCTCAAAACATCA
ACTTGGTTTACGGTCACGGTGGTGATCAGATGAAGGCTACTTTAGCTGAAGAATCGGTAAACTGGGCACTGCAAGCTGAG
CAGTTGGGTACTGGCCACGCTGTGGATCAGGCATCTGCACATTTCGCTGATGATGAAAAAGTACTGGTGCTATACGGTGA
TGTTCCATTGATTTCACCTCAAACCATTGAAAACCTATTAGACGCTCAACCAAACGGTGGCATCGCGCTACTTACGGTCG
TGTTAGACAACCCAATGGGCTACGGTCGTATTATTCGTCGCAATGGCCCTGTTGTGGCTATCGTTGAGCAGAAAGATGCA
ACGGATGAGCAGAAGCTTATCAAAGAGATCAACACTGGCGTTATGGTGGCTACTGGTGGCGATCTGAAGCGTTGGTTGTC
TGGCTTAAGCAACGATAACGCACAAGGTGAATACTACCTGACTGACGTTATTGCAGCGGCTCACGATGAAGGTCGTGCTG
TAGAAGCTGTACACCCAGTAAGCCCGATTGAAGTGGAAGGCGTGAACGACCGCTCTCAACTGGCTCGTCTAGAGCGCGCT
TATCAAGCTGAGCAAGCCGATAAACTATTGAAGCAAGGCGTTATGTTACGTGACCCAAGCCGCTTTGATCTACGCGGTGA
ATTGCAGTGTGGTATGGATGTTGAGATTGATACTAACGTTATCATTGAAGGTAGCGTAAGCATTGGCGACAACGTGGTTA
TCGGTGCCGGTTGTGTATTGAAAGACTGTGAGATTGATGACAACACCATCGTGCGTCCATACAGTGTAATTGAAGGTGCA
ACGGTCGGTGAAGACTGTACGGTTGGTCCTTTCACTCGTCTACGTCCTGGTGCTGACATGCGTAATAACTCGCATGTAGG
TAACTTTGTTGAAGTGAAGAACACTCGTCTTGGTGAGGGTTCTAAAGCGAATCACCTTACTTACCTAGGTGATGCTGAGA
TCGGTCAACGTGTAAATGTGGGTGCGGGTGCTATCACTTGTAACTACGATGGCGCGAACAAGTTTAAGACCATCATTGGC
GATGACGTATTTGTTGGCTCAGACAGCCAATTAATCGCACCTGTTACTATTGGCAACGGCGCAACTGTCGGTGCGGGCTC
TACAGTAACGCGCGATGTTTCTGAAAATGAGCTAGTTATCAGCCGTGCGAAAGAGCGCAAGATTGCCAACTGGCAGCGTC
CGACTAAGAAAAAGTAG

Upstream 100 bases:

>100_bases
TGAAAAATGCACCTTTTAAGCCCCACTACTGGTTAAATGGTTATTGTGATTTAATTTTTTTGCCAAAAACGGTTACAATA
TCGGCTTAATAAAAATACTG

Downstream 100 bases:

>100_bases
TCTCAACTATAAATCAGATGACTGCGATAGAGCTAATAGCACTGCTATTGGTTTTTCTTAGATATCTAGATATAAAAAAA
GAGCGATTAATCTCGCTCTT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDRFTMKFSAVILAAGKGTRMYSNTPKVLHTLAGKPMVKHVIDTCNGLGAQNINLVYGHGGDQMKATLAEESVNWALQAE
QLGTGHAVDQASAHFADDEKVLVLYGDVPLISPQTIENLLDAQPNGGIALLTVVLDNPMGYGRIIRRNGPVVAIVEQKDA
TDEQKLIKEINTGVMVATGGDLKRWLSGLSNDNAQGEYYLTDVIAAAHDEGRAVEAVHPVSPIEVEGVNDRSQLARLERA
YQAEQADKLLKQGVMLRDPSRFDLRGELQCGMDVEIDTNVIIEGSVSIGDNVVIGAGCVLKDCEIDDNTIVRPYSVIEGA
TVGEDCTVGPFTRLRPGADMRNNSHVGNFVEVKNTRLGEGSKANHLTYLGDAEIGQRVNVGAGAITCNYDGANKFKTIIG
DDVFVGSDSQLIAPVTIGNGATVGAGSTVTRDVSENELVISRAKERKIANWQRPTKKK

Sequences:

>Translated_458_residues
MDRFTMKFSAVILAAGKGTRMYSNTPKVLHTLAGKPMVKHVIDTCNGLGAQNINLVYGHGGDQMKATLAEESVNWALQAE
QLGTGHAVDQASAHFADDEKVLVLYGDVPLISPQTIENLLDAQPNGGIALLTVVLDNPMGYGRIIRRNGPVVAIVEQKDA
TDEQKLIKEINTGVMVATGGDLKRWLSGLSNDNAQGEYYLTDVIAAAHDEGRAVEAVHPVSPIEVEGVNDRSQLARLERA
YQAEQADKLLKQGVMLRDPSRFDLRGELQCGMDVEIDTNVIIEGSVSIGDNVVIGAGCVLKDCEIDDNTIVRPYSVIEGA
TVGEDCTVGPFTRLRPGADMRNNSHVGNFVEVKNTRLGEGSKANHLTYLGDAEIGQRVNVGAGAITCNYDGANKFKTIIG
DDVFVGSDSQLIAPVTIGNGATVGAGSTVTRDVSENELVISRAKERKIANWQRPTKKK
>Mature_458_residues
MDRFTMKFSAVILAAGKGTRMYSNTPKVLHTLAGKPMVKHVIDTCNGLGAQNINLVYGHGGDQMKATLAEESVNWALQAE
QLGTGHAVDQASAHFADDEKVLVLYGDVPLISPQTIENLLDAQPNGGIALLTVVLDNPMGYGRIIRRNGPVVAIVEQKDA
TDEQKLIKEINTGVMVATGGDLKRWLSGLSNDNAQGEYYLTDVIAAAHDEGRAVEAVHPVSPIEVEGVNDRSQLARLERA
YQAEQADKLLKQGVMLRDPSRFDLRGELQCGMDVEIDTNVIIEGSVSIGDNVVIGAGCVLKDCEIDDNTIVRPYSVIEGA
TVGEDCTVGPFTRLRPGADMRNNSHVGNFVEVKNTRLGEGSKANHLTYLGDAEIGQRVNVGAGAITCNYDGANKFKTIIG
DDVFVGSDSQLIAPVTIGNGATVGAGSTVTRDVSENELVISRAKERKIANWQRPTKKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=66.7405764966741, Blast_Score=634, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49146; Mature: 49146

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFTMKFSAVILAAGKGTRMYSNTPKVLHTLAGKPMVKHVIDTCNGLGAQNINLVYGHG
CCCEEEEEEEEEEECCCCCEEECCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC
GDQMKATLAEESVNWALQAEQLGTGHAVDQASAHFADDEKVLVLYGDVPLISPQTIENLL
CCCEEEEHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
DAQPNGGIALLTVVLDNPMGYGRIIRRNGPVVAIVEQKDATDEQKLIKEINTGVMVATGG
CCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECC
DLKRWLSGLSNDNAQGEYYLTDVIAAAHDEGRAVEAVHPVSPIEVEGVNDRSQLARLERA
HHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHH
YQAEQADKLLKQGVMLRDPSRFDLRGELQCGMDVEIDTNVIIEGSVSIGDNVVIGAGCVL
HHHHHHHHHHHCCCEEECCCCCCEEECEECCEEEEECCCEEEEECCCCCCCEEEECCEEE
KDCEIDDNTIVRPYSVIEGATVGEDCTVGPFTRLRPGADMRNNSHVGNFVEVKNTRLGEG
EECCCCCCCEECCHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCC
SKANHLTYLGDAEIGQRVNVGAGAITCNYDGANKFKTIIGDDVFVGSDSQLIAPVTIGNG
CCCCEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHEECCEEEECCCCCEEEEEEECCC
ATVGAGSTVTRDVSENELVISRAKERKIANWQRPTKKK
CEECCCCCEECCCCCCCEEEEHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDRFTMKFSAVILAAGKGTRMYSNTPKVLHTLAGKPMVKHVIDTCNGLGAQNINLVYGHG
CCCEEEEEEEEEEECCCCCEEECCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC
GDQMKATLAEESVNWALQAEQLGTGHAVDQASAHFADDEKVLVLYGDVPLISPQTIENLL
CCCEEEEHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
DAQPNGGIALLTVVLDNPMGYGRIIRRNGPVVAIVEQKDATDEQKLIKEINTGVMVATGG
CCCCCCCEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECC
DLKRWLSGLSNDNAQGEYYLTDVIAAAHDEGRAVEAVHPVSPIEVEGVNDRSQLARLERA
HHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHH
YQAEQADKLLKQGVMLRDPSRFDLRGELQCGMDVEIDTNVIIEGSVSIGDNVVIGAGCVL
HHHHHHHHHHHCCCEEECCCCCCEEECEECCEEEEECCCEEEEECCCCCCCEEEECCEEE
KDCEIDDNTIVRPYSVIEGATVGEDCTVGPFTRLRPGADMRNNSHVGNFVEVKNTRLGEG
EECCCCCCCEECCHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEECCCCCCCC
SKANHLTYLGDAEIGQRVNVGAGAITCNYDGANKFKTIIGDDVFVGSDSQLIAPVTIGNG
CCCCEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHEECCEEEECCCCCEEEEEEECCC
ATVGAGSTVTRDVSENELVISRAKERKIANWQRPTKKK
CEECCCCCEECCCCCCCEEEEHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA