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The map label for this gene is purE [H]

Identifier: 218710992

GI number: 218710992

Start: 3256700

End: 3257185

Strand: Direct

Name: purE [H]

Synonym: VS_3120

Alternate gene names: 218710992

Gene position: 3256700-3257185 (Clockwise)

Preceding gene: 218710987

Following gene: 218710993

Centisome position: 98.71

GC content: 49.59

Gene sequence:

>486_bases
ATGACTGTCGGTATTATCATGGGTTCTAAATCTGATTGGCCAACAATGAAGCTAGCTGCAGAAATGTTGGATCAGTTTGG
CGTGGCGTACGAAACAAAAGTGGTTTCTGCTCACCGCACACCTCAGTTGCTTGCAGACTACGCAACCAGTGCGAAAGAGC
GCGGTATTAAAGTGATTATTGCTGGTGCTGGCGGTGCAGCGCACCTTCCGGGCATGGCGGCTGCTTTCACAAGCGTACCA
GTTCTGGGTGTTCCAGTTCAGTCTAAAGCACTGAAAGGCATGGACTCTCTGCTTTCTATCGTGCAGATGCCAAAAGGTAT
CGCGGTAGGTACTTTGGCTATCGGTGAAGCTGGCGCTGCCAATGCAGGCATCCTAGCGGCTCAAATCATTGGTACACACA
ATGAAGAAGTAATGGCAAAAGTAGAAGCGTTCCGCTCTGAACAAACAGAAACGGTTCTGGCTAATCCAAACCCTGCAGAG
GACTAA

Upstream 100 bases:

>100_bases
CAACTTAGACTGACGCAAACGTTTTCCTTAGGCGATTTTACCCGTATAATGCGCGCAAAATATCTAATCACTAATTAAAT
CGTACCTGAAGGAGTTTGAG

Downstream 100 bases:

>100_bases
TTTCCATGCATGTTCTTGTGTTAGGCGCGGGCCAACTTGCTCGCATGATGTCCCTAGCTGGGGCACCGCTGAATATTGAA
ATTTCTGCTTTTGATGTTGG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MTVGIIMGSKSDWPTMKLAAEMLDQFGVAYETKVVSAHRTPQLLADYATSAKERGIKVIIAGAGGAAHLPGMAAAFTSVP
VLGVPVQSKALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTHNEEVMAKVEAFRSEQTETVLANPNPAE
D

Sequences:

>Translated_161_residues
MTVGIIMGSKSDWPTMKLAAEMLDQFGVAYETKVVSAHRTPQLLADYATSAKERGIKVIIAGAGGAAHLPGMAAAFTSVP
VLGVPVQSKALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTHNEEVMAKVEAFRSEQTETVLANPNPAE
D
>Mature_160_residues
TVGIIMGSKSDWPTMKLAAEMLDQFGVAYETKVVSAHRTPQLLADYATSAKERGIKVIIAGAGGAAHLPGMAAAFTSVPV
LGVPVQSKALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTHNEEVMAKVEAFRSEQTETVLANPNPAED

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=156, Percent_Identity=64.1025641025641, Blast_Score=169, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=54.9668874172185, Blast_Score=165, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16541; Mature: 16410

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGIIMGSKSDWPTMKLAAEMLDQFGVAYETKVVSAHRTPQLLADYATSAKERGIKVII
CEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHCCEEEEE
AGAGGAAHLPGMAAAFTSVPVLGVPVQSKALKGMDSLLSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NAGILAAQIIGTHNEEVMAKVEAFRSEQTETVLANPNPAED
CCCHHEEHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TVGIIMGSKSDWPTMKLAAEMLDQFGVAYETKVVSAHRTPQLLADYATSAKERGIKVII
EEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHCCEEEEE
AGAGGAAHLPGMAAAFTSVPVLGVPVQSKALKGMDSLLSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NAGILAAQIIGTHNEEVMAKVEAFRSEQTETVLANPNPAED
CCCHHEEHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]