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The map label for this gene is trxA [H]

Identifier: 218710958

GI number: 218710958

Start: 3216137

End: 3216475

Strand: Reverse

Name: trxA [H]

Synonym: VS_3072

Alternate gene names: 218710958

Gene position: 3216475-3216137 (Counterclockwise)

Preceding gene: 218710961

Following gene: 218710957

Centisome position: 97.49

GC content: 41.89

Gene sequence:

>339_bases
TTGGAGTGGAAGATGAGTGATAAGATTTTGCAGCTAACTGATGACGGTTTTGATAACGATGTAATCAACGCTGCAGGCCC
TGTTCTTGTTGATTTTTGGGCAGAATGGTGTGGTCCATGTAAAATGATTGCGCCGATTCTTGATGAAATCGCAAACGAGT
ACGAAGGTCAGCTCACAATCGGTAAATTAAATATCGACCAAAATGCTGGTACTCCACCAAAATTCGGTATTCGCGGTATT
CCAACGCTACTTCTTTTCAAAGACGGTGGCGTAGCAGCAACTAAAGTTGGTGCATTGTCTAAAACTCAACTTAAAGAGTT
CCTAGACGCTAACCTATAA

Upstream 100 bases:

>100_bases
TTGCTATAGAATATCAGCTTAAGCTTGCAATACGAAAGTAAATACATTCCAATAGGGCATCTATTTACTGGTTATCATCC
AACCAGTTCTAAAAAACACA

Downstream 100 bases:

>100_bases
TCAGGTGAGTATTTGAAAAGAAACCGCGCAGTTAACAAATGCGCGGTTTTGTTTTTTCTAAGCTATGGACTAGTCTTAGT
TTTAGTGCTAATTTATCGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MEWKMSDKILQLTDDGFDNDVINAAGPVLVDFWAEWCGPCKMIAPILDEIANEYEGQLTIGKLNIDQNAGTPPKFGIRGI
PTLLLFKDGGVAATKVGALSKTQLKEFLDANL

Sequences:

>Translated_112_residues
MEWKMSDKILQLTDDGFDNDVINAAGPVLVDFWAEWCGPCKMIAPILDEIANEYEGQLTIGKLNIDQNAGTPPKFGIRGI
PTLLLFKDGGVAATKVGALSKTQLKEFLDANL
>Mature_112_residues
MEWKMSDKILQLTDDGFDNDVINAAGPVLVDFWAEWCGPCKMIAPILDEIANEYEGQLTIGKLNIDQNAGTPPKFGIRGI
PTLLLFKDGGVAATKVGALSKTQLKEFLDANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=35.8695652173913, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=31.7647058823529, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=81.4814814814815, Blast_Score=184, Evalue=2e-48,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=39.4495412844037, Blast_Score=89, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=37.6344086021505, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=40.6976744186046, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=37.2093023255814, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=36.046511627907, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=37.9310344827586, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=84, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=87, Percent_Identity=37.9310344827586, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=106, Percent_Identity=33.0188679245283, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=39.0804597701149, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=42.8571428571429, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=32.9896907216495, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=41.0958904109589, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=35.2272727272727, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=30.0970873786408, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12195; Mature: 12195

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWKMSDKILQLTDDGFDNDVINAAGPVLVDFWAEWCGPCKMIAPILDEIANEYEGQLTI
CCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEE
GKLNIDQNAGTPPKFGIRGIPTLLLFKDGGVAATKVGALSKTQLKEFLDANL
EEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MEWKMSDKILQLTDDGFDNDVINAAGPVLVDFWAEWCGPCKMIAPILDEIANEYEGQLTI
CCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEE
GKLNIDQNAGTPPKFGIRGIPTLLLFKDGGVAATKVGALSKTQLKEFLDANL
EEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]