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The map label for this gene is cvrA [H]

Identifier: 218710849

GI number: 218710849

Start: 3086475

End: 3088226

Strand: Reverse

Name: cvrA [H]

Synonym: VS_2932

Alternate gene names: 218710849

Gene position: 3088226-3086475 (Counterclockwise)

Preceding gene: 218710854

Following gene: 218710837

Centisome position: 93.6

GC content: 48.74

Gene sequence:

>1752_bases
TTGGACGCAATAACCATTAACCACTTATTTTTAACTGGTGCGGTGCTCATCGCCATCAGTGTGCTTTTTTCGCAAGTGTC
CTCTCGCTTGGGCGTTCCGATTCTTTTGATCTTCCTTTTCGTTGGCATGTTAGCCGGTGAAGATGGACCCGGTGGCATTA
ATTTTGATGATTACTCACTGACTTATTTGGTGAGTAACCTCGCGCTTGCCGTGATCCTGCTTGATGGCGGTATGCGAACC
AAGGTCGCAAGCTTCAAGGTTGCGTTTTGGCCATCGCTCTCGCTGGCGACGATAGGTGTCGCGTGTACTGCAACCCTAAC
GGGCTTAATGGCGGCTTGGCTGTTCGATCTGTCATTGATGCAGGGTATCTTAGTCGGTGCCATTGTAGGCTCAACCGATG
CAGCTGCGGTATTTTCTTTGTTGAAAGGGCAAAGCCTCAATGAACGTGTTGGTTCAACCCTAGAGATCGAATCCGGTACC
AATGACCCAATGGCTGTTTTCCTGACAGTGACTTTAATTGCGCTACTGGGTACCCCAGATGCCGAGATGGGAATGAACTT
CCTACTCAAAAGCTTCGCGATGCAGTTTGGTATCGGCACCCTTGTTGGTATCGGTGGCGGTTGGGTTCTATGGAGTCTAA
TTAACCGAGTACAGCTGGCCGATGGCCTTTACTCTATTTTGGTGCTCAGTGGTGGTGTGGCGCTGTTTGCGTTCTCTAAC
ATGCTGGGCGGCAGCGGTATCTTATCGATCTACCTTGTAGGCCTGTTCATTGGTAATCGTCCGACGCGCTCTCGACACTC
TATTCTTAATGTTCTTGATGGTATGACGTGGCTAAGCCAGATCGTGATGTTCTTGGTATTGGGCTTATTGGTGACGCCAT
CAACGTTGATGGACATTGCTCTGCCTGCGCTAGCGCTGGCCTTCGGTATGATTTTGTTTGCTCGTCCGCTGTCGGTTTGG
TTGGGTTTACTGCCGTTCAGAAGCTTTACCACCAAAGAACGTTGGTTTGTTTCTTGGGTAGGTTTACGTGGCGCTGTGCC
GATCATTTTGGCGGTGTTCCCGATGATGGCTGGCCTGCCCAATGCTCAGCTTTACTTCAATATTGCCTTCTTCGTGGTTA
TGGTTTCGCTGATTGTTCAGGGCGGTAGCTTGATGAAAGTTGCGAGGTTGGCTCAGGTGACCTTACCACCGACACCAACA
CCGATTTCTCGTACTGGCATGGAGATTTATCCGACCAGTGAGTGGGAGATGTTTGTCTACAAGCTGAAAGAAGAAAAGTG
GTGTGTTGGTGAACCGCTTAAGCGTTTGTCTATGCCTGAAGGGACGCGAATTACGGCACTGTTTAGAAAAGATGCTTTGC
TTCACCCATCGGGTAGCACCGTGTTAGAGGCGAACGATATTCTCTGTGTGCTTGGTCAAGATAAAGACCTAGATAGCTTA
AGTGCGCTATTCAGTGAGGCTCCTCTAGCTGAAGAGGCCGCTCGATTCTTTGGTGATTTCTTCCTGGATGTCGAACTATC
GATTGCAGCGGTCAGTGATTGTTATGGTATCGAACTGGGCTCGGAAGAAGAGCGAGAAATGACGCTAAAACAATTGGCTG
AGCGAGAGCTTGGTGCACATCCTGTATTAGGTGATAGCTTTATGTGGCATGACATTACTTGGGTGGTCGCAGAGATAGAT
GATCATAAAGTCGTCAGGTTGGGTTTATGTTTGCCAAAGACGACTTTAGAAGAGGATATAAGTGAAGTTTAG

Upstream 100 bases:

>100_bases
CTTTCACCGGTCGTGACTTGCTCAACGGCAGAAGATCAACAAGCTAGTGGCAAAAGATCAACAGGCTTAAGGCTCGAGTT
TTATTCTTTGGGGGGACGAA

Downstream 100 bases:

>100_bases
TTGTGGACTTCTTGTAGCAAGATAACCGCCTGAGTTCGGTTTTTCACATCCAGTTTACGGAAGATGGCTGTCATATGTGC
TTTGATAGTCGCTTCCGAAA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MDAITINHLFLTGAVLIAISVLFSQVSSRLGVPILLIFLFVGMLAGEDGPGGINFDDYSLTYLVSNLALAVILLDGGMRT
KVASFKVAFWPSLSLATIGVACTATLTGLMAAWLFDLSLMQGILVGAIVGSTDAAAVFSLLKGQSLNERVGSTLEIESGT
NDPMAVFLTVTLIALLGTPDAEMGMNFLLKSFAMQFGIGTLVGIGGGWVLWSLINRVQLADGLYSILVLSGGVALFAFSN
MLGGSGILSIYLVGLFIGNRPTRSRHSILNVLDGMTWLSQIVMFLVLGLLVTPSTLMDIALPALALAFGMILFARPLSVW
LGLLPFRSFTTKERWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNIAFFVVMVSLIVQGGSLMKVARLAQVTLPPTPT
PISRTGMEIYPTSEWEMFVYKLKEEKWCVGEPLKRLSMPEGTRITALFRKDALLHPSGSTVLEANDILCVLGQDKDLDSL
SALFSEAPLAEEAARFFGDFFLDVELSIAAVSDCYGIELGSEEEREMTLKQLAERELGAHPVLGDSFMWHDITWVVAEID
DHKVVRLGLCLPKTTLEEDISEV

Sequences:

>Translated_583_residues
MDAITINHLFLTGAVLIAISVLFSQVSSRLGVPILLIFLFVGMLAGEDGPGGINFDDYSLTYLVSNLALAVILLDGGMRT
KVASFKVAFWPSLSLATIGVACTATLTGLMAAWLFDLSLMQGILVGAIVGSTDAAAVFSLLKGQSLNERVGSTLEIESGT
NDPMAVFLTVTLIALLGTPDAEMGMNFLLKSFAMQFGIGTLVGIGGGWVLWSLINRVQLADGLYSILVLSGGVALFAFSN
MLGGSGILSIYLVGLFIGNRPTRSRHSILNVLDGMTWLSQIVMFLVLGLLVTPSTLMDIALPALALAFGMILFARPLSVW
LGLLPFRSFTTKERWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNIAFFVVMVSLIVQGGSLMKVARLAQVTLPPTPT
PISRTGMEIYPTSEWEMFVYKLKEEKWCVGEPLKRLSMPEGTRITALFRKDALLHPSGSTVLEANDILCVLGQDKDLDSL
SALFSEAPLAEEAARFFGDFFLDVELSIAAVSDCYGIELGSEEEREMTLKQLAERELGAHPVLGDSFMWHDITWVVAEID
DHKVVRLGLCLPKTTLEEDISEV
>Mature_583_residues
MDAITINHLFLTGAVLIAISVLFSQVSSRLGVPILLIFLFVGMLAGEDGPGGINFDDYSLTYLVSNLALAVILLDGGMRT
KVASFKVAFWPSLSLATIGVACTATLTGLMAAWLFDLSLMQGILVGAIVGSTDAAAVFSLLKGQSLNERVGSTLEIESGT
NDPMAVFLTVTLIALLGTPDAEMGMNFLLKSFAMQFGIGTLVGIGGGWVLWSLINRVQLADGLYSILVLSGGVALFAFSN
MLGGSGILSIYLVGLFIGNRPTRSRHSILNVLDGMTWLSQIVMFLVLGLLVTPSTLMDIALPALALAFGMILFARPLSVW
LGLLPFRSFTTKERWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNIAFFVVMVSLIVQGGSLMKVARLAQVTLPPTPT
PISRTGMEIYPTSEWEMFVYKLKEEKWCVGEPLKRLSMPEGTRITALFRKDALLHPSGSTVLEANDILCVLGQDKDLDSL
SALFSEAPLAEEAARFFGDFFLDVELSIAAVSDCYGIELGSEEEREMTLKQLAERELGAHPVLGDSFMWHDITWVVAEID
DHKVVRLGLCLPKTTLEEDISEV

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=578, Percent_Identity=56.9204152249135, Blast_Score=606, Evalue=1e-174,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63053; Mature: 63053

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAITINHLFLTGAVLIAISVLFSQVSSRLGVPILLIFLFVGMLAGEDGPGGINFDDYSL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
TYLVSNLALAVILLDGGMRTKVASFKVAFWPSLSLATIGVACTATLTGLMAAWLFDLSLM
HHHHHHHHHEEEEECCCCCEEHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGILVGAIVGSTDAAAVFSLLKGQSLNERVGSTLEIESGTNDPMAVFLTVTLIALLGTPD
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCC
AEMGMNFLLKSFAMQFGIGTLVGIGGGWVLWSLINRVQLADGLYSILVLSGGVALFAFSN
HHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MLGGSGILSIYLVGLFIGNRPTRSRHSILNVLDGMTWLSQIVMFLVLGLLVTPSTLMDIA
HCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPALALAFGMILFARPLSVWLGLLPFRSFTTKERWFVSWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEHHHCCHHHHHHHHHHHHHCCC
NAQLYFNIAFFVVMVSLIVQGGSLMKVARLAQVTLPPTPTPISRTGMEIYPTSEWEMFVY
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCEEEEE
KLKEEKWCVGEPLKRLSMPEGTRITALFRKDALLHPSGSTVLEANDILCVLGQDKDLDSL
EECCCCCCCCCHHHHCCCCCCCEEEEEECCCCEECCCCCCEEECCCEEEEECCCCCHHHH
SALFSEAPLAEEAARFFGDFFLDVELSIAAVSDCYGIELGSEEEREMTLKQLAERELGAH
HHHHHCCCCHHHHHHHHHHHHEEEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
PVLGDSFMWHDITWVVAEIDDHKVVRLGLCLPKTTLEEDISEV
CCCCCCEEHHCEEEEEEECCCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MDAITINHLFLTGAVLIAISVLFSQVSSRLGVPILLIFLFVGMLAGEDGPGGINFDDYSL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
TYLVSNLALAVILLDGGMRTKVASFKVAFWPSLSLATIGVACTATLTGLMAAWLFDLSLM
HHHHHHHHHEEEEECCCCCEEHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGILVGAIVGSTDAAAVFSLLKGQSLNERVGSTLEIESGTNDPMAVFLTVTLIALLGTPD
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCC
AEMGMNFLLKSFAMQFGIGTLVGIGGGWVLWSLINRVQLADGLYSILVLSGGVALFAFSN
HHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MLGGSGILSIYLVGLFIGNRPTRSRHSILNVLDGMTWLSQIVMFLVLGLLVTPSTLMDIA
HCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPALALAFGMILFARPLSVWLGLLPFRSFTTKERWFVSWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEHHHCCHHHHHHHHHHHHHCCC
NAQLYFNIAFFVVMVSLIVQGGSLMKVARLAQVTLPPTPTPISRTGMEIYPTSEWEMFVY
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCEEEEE
KLKEEKWCVGEPLKRLSMPEGTRITALFRKDALLHPSGSTVLEANDILCVLGQDKDLDSL
EECCCCCCCCCHHHHCCCCCCCEEEEEECCCCEECCCCCCEEECCCEEEEECCCCCHHHH
SALFSEAPLAEEAARFFGDFFLDVELSIAAVSDCYGIELGSEEEREMTLKQLAERELGAH
HHHHHCCCCHHHHHHHHHHHHEEEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
PVLGDSFMWHDITWVVAEIDDHKVVRLGLCLPKTTLEEDISEV
CCCCCCEEHHCEEEEEEECCCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]