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The map label for this gene is fkpA [H]

Identifier: 218710759

GI number: 218710759

Start: 2987420

End: 2988208

Strand: Reverse

Name: fkpA [H]

Synonym: VS_2842

Alternate gene names: 218710759

Gene position: 2988208-2987420 (Counterclockwise)

Preceding gene: 218710762

Following gene: 218710758

Centisome position: 90.57

GC content: 45.5

Gene sequence:

>789_bases
TTGGAGAATTCAATGAAATCAGTTTTAAAAGTATCACTGCTTGCCGCAACGGTTATGCTAGCAGTTGGTTGTCAGAAAGA
AGAACCAAAGGCAGAAGCTCCACAGGTAGAAGAAGTTAAAGTTGCAGCAGTAAACTTTAAAACAGAAGATGACAAAGCGG
CATACGCAATCGGTGTATCTTTCGCTAACTACTTAAGCACAAGCATTGATAAGCCAAGCGAGCTAGGTATTAACCTAGAC
AAAGCGATGGTTCTTCAAGGTATCGAAGACGTATTCGCAGAGAAGACGGCACTTAACGAAGAAGAGACTCGTGCAGCTCT
TGAAGCTCTAGACAAGCGTGTTGCTGAAACGATGCAAGCACAAGCGGCAGAAAAGTCTGCAGAAGTGAAGAAAGCGGGTG
ATGACTTCCGCGCTGAGTTCGCTAAAACTGAAGGCGTTAAGCAAACTGAATCTGGTCTACTTTACCAAGTAATGACGGCT
GGTGAAGGCGCTTCTCCAAAAGACACTGATACGGTTCAAGTACACTACAAAGGTACGCTAACAGACGGTACTCAGTTCGA
CAGCTCTTACGATCGTGGCGAACCAGCAACATTCCCACTAAACCGCGTAATCCCAGGCTGGACTGAAGGCGTACAACTGA
TGCAAGTGGGTTCTAAGTACAAGTTCGTTATCCCGCCAGAGCTAGCATACGGTGAACAAGATACACCGACTATCCCAGCT
AACTCAACGCTAGTATTCGAAGTAGAACTACTAAATATCGATAACGCTGAAGCAGCTCCTGCACAATAA

Upstream 100 bases:

>100_bases
TGTGTCGAAAGACATATGACTAGTATATTGTTATAACTAACGTATTCACACCAATCTAATCATTAGATTTGTGCACAATA
ACCAATGGCTTGGCCATTAA

Downstream 100 bases:

>100_bases
TATCGGTTAAAAGCCTCGTGCTAAAATACGTTGATTGAATAAAAAGCCTAACTTTAAGTTAGGCTTTTTTTATGACTTGA
ATATGAGTATTTGATTTTTA

Product: FkpA protein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MENSMKSVLKVSLLAATVMLAVGCQKEEPKAEAPQVEEVKVAAVNFKTEDDKAAYAIGVSFANYLSTSIDKPSELGINLD
KAMVLQGIEDVFAEKTALNEEETRAALEALDKRVAETMQAQAAEKSAEVKKAGDDFRAEFAKTEGVKQTESGLLYQVMTA
GEGASPKDTDTVQVHYKGTLTDGTQFDSSYDRGEPATFPLNRVIPGWTEGVQLMQVGSKYKFVIPPELAYGEQDTPTIPA
NSTLVFEVELLNIDNAEAAPAQ

Sequences:

>Translated_262_residues
MENSMKSVLKVSLLAATVMLAVGCQKEEPKAEAPQVEEVKVAAVNFKTEDDKAAYAIGVSFANYLSTSIDKPSELGINLD
KAMVLQGIEDVFAEKTALNEEETRAALEALDKRVAETMQAQAAEKSAEVKKAGDDFRAEFAKTEGVKQTESGLLYQVMTA
GEGASPKDTDTVQVHYKGTLTDGTQFDSSYDRGEPATFPLNRVIPGWTEGVQLMQVGSKYKFVIPPELAYGEQDTPTIPA
NSTLVFEVELLNIDNAEAAPAQ
>Mature_262_residues
MENSMKSVLKVSLLAATVMLAVGCQKEEPKAEAPQVEEVKVAAVNFKTEDDKAAYAIGVSFANYLSTSIDKPSELGINLD
KAMVLQGIEDVFAEKTALNEEETRAALEALDKRVAETMQAQAAEKSAEVKKAGDDFRAEFAKTEGVKQTESGLLYQVMTA
GEGASPKDTDTVQVHYKGTLTDGTQFDSSYDRGEPATFPLNRVIPGWTEGVQLMQVGSKYKFVIPPELAYGEQDTPTIPA
NSTLVFEVELLNIDNAEAAPAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=110, Percent_Identity=43.6363636363636, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI224809327, Length=110, Percent_Identity=43.6363636363636, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4758384, Length=110, Percent_Identity=43.6363636363636, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=45.7943925233645, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=45.7943925233645, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI224809331, Length=110, Percent_Identity=43.6363636363636, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=41.1214953271028, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503729, Length=118, Percent_Identity=44.0677966101695, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33469985, Length=88, Percent_Identity=40.9090909090909, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI8923659, Length=95, Percent_Identity=41.0526315789474, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=43.5294117647059, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503727, Length=110, Percent_Identity=39.0909090909091, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789745, Length=258, Percent_Identity=46.1240310077519, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082390, Length=217, Percent_Identity=46.0829493087558, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=48.9130434782609, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=45.7943925233645, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=117, Percent_Identity=41.025641025641, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=52.7472527472528, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=46.5346534653465, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323566, Length=111, Percent_Identity=40.5405405405405, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=109, Percent_Identity=39.4495412844037, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=51.063829787234, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=51.063829787234, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24655568, Length=101, Percent_Identity=47.5247524752475, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356629, Length=92, Percent_Identity=48.9130434782609, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583150, Length=117, Percent_Identity=37.6068376068376, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=43.010752688172, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28292; Mature: 28292

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSMKSVLKVSLLAATVMLAVGCQKEEPKAEAPQVEEVKVAAVNFKTEDDKAAYAIGVS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEHHH
FANYLSTSIDKPSELGINLDKAMVLQGIEDVFAEKTALNEEETRAALEALDKRVAETMQA
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QAAEKSAEVKKAGDDFRAEFAKTEGVKQTESGLLYQVMTAGEGASPKDTDTVQVHYKGTL
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEE
TDGTQFDSSYDRGEPATFPLNRVIPGWTEGVQLMQVGSKYKFVIPPELAYGEQDTPTIPA
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCCCC
NSTLVFEVELLNIDNAEAAPAQ
CCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MENSMKSVLKVSLLAATVMLAVGCQKEEPKAEAPQVEEVKVAAVNFKTEDDKAAYAIGVS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEHHH
FANYLSTSIDKPSELGINLDKAMVLQGIEDVFAEKTALNEEETRAALEALDKRVAETMQA
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QAAEKSAEVKKAGDDFRAEFAKTEGVKQTESGLLYQVMTAGEGASPKDTDTVQVHYKGTL
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEE
TDGTQFDSSYDRGEPATFPLNRVIPGWTEGVQLMQVGSKYKFVIPPELAYGEQDTPTIPA
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCCCC
NSTLVFEVELLNIDNAEAAPAQ
CCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]