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The map label for this gene is cpdB [H]

Identifier: 218710707

GI number: 218710707

Start: 2954226

End: 2956202

Strand: Direct

Name: cpdB [H]

Synonym: VS_2790

Alternate gene names: 218710707

Gene position: 2954226-2956202 (Clockwise)

Preceding gene: 218710702

Following gene: 218710708

Centisome position: 89.54

GC content: 45.68

Gene sequence:

>1977_bases
ATGAAAGTTGCAATGAAACCTTTGTCATTGGCTGTACTTGCGGGTCTTGGTTTGACTTTAGCAGGCTGCACAACAACACC
AGATACCGATGAAGTGATTAAATTACGTGTCGTAGAAACGACGGATATCCATACCAACCTAATGGATTACGACTACTACA
AAGACAAGCCGTCGAAAAAAATCGGCTTAGCACGTACTGCAACTCTAGTAAAAGAAGCTCAAAGCGAAGTAACCAACAGC
GTATTAGTTGATAATGGTGACTTGCTGCAAGGTAGCCCGATGGGTGACTACATGGCAGACAAAGGCATCGAAGCGGGCGA
AGTTCACCCTGCATACAAAGCAATGAATCAACTAAGCTACGACGCTGCAAACCTAGGTAACCACGAATTCAACTACGGTC
TTGAGTTCCTAGAAGAATCTATTAACGACGCTGATTTCCCGTACATCAGTGCTAACGTTTACGACGCAGAAACCAAAGAA
CACTACTTCACGCCTTACATCATCAAGACGCACACCTTTGAAGATACTGCTGGCGTAGAGCACGAAGTAAAAGTGGGTTA
CATCGGTTTCGTTCCACCACAAATCATGACGTGGGATAAGAAGAACCTTGAAGGCAAAGTGATCGCTCGCGATATCATTG
AGACGGCTAACGAGCTAGTGCCTAAAATGAAAGCGGAAGGCGCTGAAGTTATCGTTGCTATCCCTCACTCAGGCGTATCA
ACTGACCCATACAAAAATGGCGAAGAGAACTCAACGTTCTACCTATCTGAAGTAGACGGCATTGATGCAATCGCATTCGG
CCACTCTCACGCAGTGTTCCCAGGTAAAGGTTTTGATGACATCCAAGGCATCGACAACGAAACGGGCACAATGAACGGCG
TTGCGGCAGTAATGCCAGGTCGTTGGGGTAGCCACGTTGGTGTTATGGATCTAACACTTGCACAAAAAGACGGTAAGTGG
GAAGTCGTTAAAGGCCAATCAGAAGCACGCCCAATCTACGACAAGGTAGAAAAGAAATCTCTTGCCGCAGCTGATGAAGG
CATCGTAACAGCACTTGAAAAAGACCACGCTGGTACTCGTGAGTTTGTTAACCAACCGATTGGTAAAGCAGACGATGTGA
TGTACAGCTTCTTGTCTCTAGTACAAGACGATCCAACAGTTCAAATCGTTAACCTTGCGCAAAAAGATTACGTTGAGCAG
TTCATCCAAGGTGATCCAGATTTAGATGGCACACCTGTACTTTCTGCAGCTGCACCATTCAAAGCAGGCGGCCGTAAGAA
TGACCCAGCGAACTTCACTGAAGTTGAATCTGGTCAACTGACATTCCGTAACGCGGCTGACTTATACCTTTACCCGAACA
CGCTAGTTGCGATGAAGGTAACAGGTCACGAAGTAAAAGAGTGGCTTGAGTGTTCTGCAGGTCAGTTCAACCAAGTGGAT
GTTAACTCAACAGCACCACAACAATTGATCGAGTGGGATAACTTCCGCACTTACAACTTCGATGTTATCGATGGTGTTGA
TTACCAAATCGACGTAACTCAACCTGCGAAATACGATGCAAACTGTAAAGTCGTTAACCCTGACTCACAACGTATTGTTG
GCCTAACTTACCAAGGTAAGCCAATCGACATGAAGCAAGACTTCCTGATTGCCACCAACAACTACCGTGCATACAGCGCT
AAATTCCCAGGTACAGGCGAAGACTTCATCGCATTTGATGCACCAGATGAGAACCGTACTGTTCTTGCAAACTACATCTC
TCGCGTAAGCAAAGAGCAAGGTCAAGTGAGCCCAAGCGCGGATAACAATTGGTCATTTGCACCAATCAAAACGGATAACA
AGCTAGATATCCGCTTTGAAACATCTCCAAGCGACAAAGCAGCAGAGTTCATCAAAGAAAAGGGTCAATACCCGATGAAA
CGTGTTGCGACTGACGATGTTGGTTTTGCTGTTTACCAGATTGACCTAACTAAATAG

Upstream 100 bases:

>100_bases
TCGATCTAAGTCACGAATTAACATTCGTTGTAATCATTGTTTCATTCGGTTTTGTTACATTACGCAACGAATTTTCTACT
ATCCACTTTGGAGCTACAAA

Downstream 100 bases:

>100_bases
ATTGCTTAAGTAATCCATAGTTAACGTTCTGAAAGGCTGAGTTTAACGACTCAGCCTTTTTCTTTTCTTCTAAATGTTCA
GCCCAAAGCCCTAATTTTCG

Product: bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MKVAMKPLSLAVLAGLGLTLAGCTTTPDTDEVIKLRVVETTDIHTNLMDYDYYKDKPSKKIGLARTATLVKEAQSEVTNS
VLVDNGDLLQGSPMGDYMADKGIEAGEVHPAYKAMNQLSYDAANLGNHEFNYGLEFLEESINDADFPYISANVYDAETKE
HYFTPYIIKTHTFEDTAGVEHEVKVGYIGFVPPQIMTWDKKNLEGKVIARDIIETANELVPKMKAEGAEVIVAIPHSGVS
TDPYKNGEENSTFYLSEVDGIDAIAFGHSHAVFPGKGFDDIQGIDNETGTMNGVAAVMPGRWGSHVGVMDLTLAQKDGKW
EVVKGQSEARPIYDKVEKKSLAAADEGIVTALEKDHAGTREFVNQPIGKADDVMYSFLSLVQDDPTVQIVNLAQKDYVEQ
FIQGDPDLDGTPVLSAAAPFKAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTLVAMKVTGHEVKEWLECSAGQFNQVD
VNSTAPQQLIEWDNFRTYNFDVIDGVDYQIDVTQPAKYDANCKVVNPDSQRIVGLTYQGKPIDMKQDFLIATNNYRAYSA
KFPGTGEDFIAFDAPDENRTVLANYISRVSKEQGQVSPSADNNWSFAPIKTDNKLDIRFETSPSDKAAEFIKEKGQYPMK
RVATDDVGFAVYQIDLTK

Sequences:

>Translated_658_residues
MKVAMKPLSLAVLAGLGLTLAGCTTTPDTDEVIKLRVVETTDIHTNLMDYDYYKDKPSKKIGLARTATLVKEAQSEVTNS
VLVDNGDLLQGSPMGDYMADKGIEAGEVHPAYKAMNQLSYDAANLGNHEFNYGLEFLEESINDADFPYISANVYDAETKE
HYFTPYIIKTHTFEDTAGVEHEVKVGYIGFVPPQIMTWDKKNLEGKVIARDIIETANELVPKMKAEGAEVIVAIPHSGVS
TDPYKNGEENSTFYLSEVDGIDAIAFGHSHAVFPGKGFDDIQGIDNETGTMNGVAAVMPGRWGSHVGVMDLTLAQKDGKW
EVVKGQSEARPIYDKVEKKSLAAADEGIVTALEKDHAGTREFVNQPIGKADDVMYSFLSLVQDDPTVQIVNLAQKDYVEQ
FIQGDPDLDGTPVLSAAAPFKAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTLVAMKVTGHEVKEWLECSAGQFNQVD
VNSTAPQQLIEWDNFRTYNFDVIDGVDYQIDVTQPAKYDANCKVVNPDSQRIVGLTYQGKPIDMKQDFLIATNNYRAYSA
KFPGTGEDFIAFDAPDENRTVLANYISRVSKEQGQVSPSADNNWSFAPIKTDNKLDIRFETSPSDKAAEFIKEKGQYPMK
RVATDDVGFAVYQIDLTK
>Mature_658_residues
MKVAMKPLSLAVLAGLGLTLAGCTTTPDTDEVIKLRVVETTDIHTNLMDYDYYKDKPSKKIGLARTATLVKEAQSEVTNS
VLVDNGDLLQGSPMGDYMADKGIEAGEVHPAYKAMNQLSYDAANLGNHEFNYGLEFLEESINDADFPYISANVYDAETKE
HYFTPYIIKTHTFEDTAGVEHEVKVGYIGFVPPQIMTWDKKNLEGKVIARDIIETANELVPKMKAEGAEVIVAIPHSGVS
TDPYKNGEENSTFYLSEVDGIDAIAFGHSHAVFPGKGFDDIQGIDNETGTMNGVAAVMPGRWGSHVGVMDLTLAQKDGKW
EVVKGQSEARPIYDKVEKKSLAAADEGIVTALEKDHAGTREFVNQPIGKADDVMYSFLSLVQDDPTVQIVNLAQKDYVEQ
FIQGDPDLDGTPVLSAAAPFKAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTLVAMKVTGHEVKEWLECSAGQFNQVD
VNSTAPQQLIEWDNFRTYNFDVIDGVDYQIDVTQPAKYDANCKVVNPDSQRIVGLTYQGKPIDMKQDFLIATNNYRAYSA
KFPGTGEDFIAFDAPDENRTVLANYISRVSKEQGQVSPSADNNWSFAPIKTDNKLDIRFETSPSDKAAEFIKEKGQYPMK
RVATDDVGFAVYQIDLTK

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=626, Percent_Identity=64.2172523961661, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1786687, Length=602, Percent_Identity=23.7541528239203, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19922444, Length=213, Percent_Identity=29.1079812206573, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19922446, Length=236, Percent_Identity=27.9661016949153, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24654424, Length=236, Percent_Identity=27.9661016949153, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 72516; Mature: 72516

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAMKPLSLAVLAGLGLTLAGCTTTPDTDEVIKLRVVETTDIHTNLMDYDYYKDKPSKK
CCCCCCHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHCCCCCCC
IGLARTATLVKEAQSEVTNSVLVDNGDLLQGSPMGDYMADKGIEAGEVHPAYKAMNQLSY
CCHHHHHHHHHHHHHHHHCEEEECCCCEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHCC
DAANLGNHEFNYGLEFLEESINDADFPYISANVYDAETKEHYFTPYIIKTHTFEDTAGVE
CHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
HEVKVGYIGFVPPQIMTWDKKNLEGKVIARDIIETANELVPKMKAEGAEVIVAIPHSGVS
EEEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
TDPYKNGEENSTFYLSEVDGIDAIAFGHSHAVFPGKGFDDIQGIDNETGTMNGVAAVMPG
CCCCCCCCCCCEEEEEECCCCEEEEECCCCEECCCCCCHHHCCCCCCCCCCCCEEEECCC
RWGSHVGVMDLTLAQKDGKWEVVKGQSEARPIYDKVEKKSLAAADEGIVTALEKDHAGTR
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCH
EFVNQPIGKADDVMYSFLSLVQDDPTVQIVNLAQKDYVEQFIQGDPDLDGTPVLSAAAPF
HHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCCCC
KAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTLVAMKVTGHEVKEWLECSAGQFNQVD
CCCCCCCCCCCCEECCCCEEEEECCCEEEEECCEEEEEEECCHHHHHHHHCCCCCCCEEE
VNSTAPQQLIEWDNFRTYNFDVIDGVDYQIDVTQPAKYDANCKVVNPDSQRIVGLTYQGK
CCCCCHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCC
PIDMKQDFLIATNNYRAYSAKFPGTGEDFIAFDAPDENRTVLANYISRVSKEQGQVSPSA
CCCCCCCEEEEECCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
DNNWSFAPIKTDNKLDIRFETSPSDKAAEFIKEKGQYPMKRVATDDVGFAVYQIDLTK
CCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKVAMKPLSLAVLAGLGLTLAGCTTTPDTDEVIKLRVVETTDIHTNLMDYDYYKDKPSKK
CCCCCCHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHCCCCCCC
IGLARTATLVKEAQSEVTNSVLVDNGDLLQGSPMGDYMADKGIEAGEVHPAYKAMNQLSY
CCHHHHHHHHHHHHHHHHCEEEECCCCEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHCC
DAANLGNHEFNYGLEFLEESINDADFPYISANVYDAETKEHYFTPYIIKTHTFEDTAGVE
CHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
HEVKVGYIGFVPPQIMTWDKKNLEGKVIARDIIETANELVPKMKAEGAEVIVAIPHSGVS
EEEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
TDPYKNGEENSTFYLSEVDGIDAIAFGHSHAVFPGKGFDDIQGIDNETGTMNGVAAVMPG
CCCCCCCCCCCEEEEEECCCCEEEEECCCCEECCCCCCHHHCCCCCCCCCCCCEEEECCC
RWGSHVGVMDLTLAQKDGKWEVVKGQSEARPIYDKVEKKSLAAADEGIVTALEKDHAGTR
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHCCCCCH
EFVNQPIGKADDVMYSFLSLVQDDPTVQIVNLAQKDYVEQFIQGDPDLDGTPVLSAAAPF
HHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCCCC
KAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTLVAMKVTGHEVKEWLECSAGQFNQVD
CCCCCCCCCCCCEECCCCEEEEECCCEEEEECCEEEEEEECCHHHHHHHHCCCCCCCEEE
VNSTAPQQLIEWDNFRTYNFDVIDGVDYQIDVTQPAKYDANCKVVNPDSQRIVGLTYQGK
CCCCCHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCC
PIDMKQDFLIATNNYRAYSAKFPGTGEDFIAFDAPDENRTVLANYISRVSKEQGQVSPSA
CCCCCCCEEEEECCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
DNNWSFAPIKTDNKLDIRFETSPSDKAAEFIKEKGQYPMKRVATDDVGFAVYQIDLTK
CCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3005231; 7610040; 9278503; 2172762; 9298646 [H]