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The map label for this gene is plsC [H]

Identifier: 218710663

GI number: 218710663

Start: 2910901

End: 2911647

Strand: Reverse

Name: plsC [H]

Synonym: VS_2743

Alternate gene names: 218710663

Gene position: 2911647-2910901 (Counterclockwise)

Preceding gene: 218710664

Following gene: 218710657

Centisome position: 88.25

GC content: 45.38

Gene sequence:

>747_bases
TTGCGGTTGGTGAGGAACAAAATGATAGCAATATTACGTATTTTCGCTGTAGCGATATTTGCGATTCTTATGTTTGTATT
TGGTTGTGGTTACTGTCTATTAAGCCCACGTAACCCGAAACACGTATTTACCTTTGGCCGTTATTTCGGTCGCATGTCGA
AAATCTTTGGCATGAAGTTAGAGCTTCGTATCCCGGAAGATGCTTACTCTCGCGGCCAACATGTTTACGTTGCAAACCAC
CAAAACAGCTGGGACCTATTCACGATTTCATCAGCGGTAACACCTAAGGTTGTGACTGTTGGTAAGAAGAGCTTAGCGTG
GATGCCTCTTTTTGGTCAGCTGTATTGGCTGACGGGTAATATCCTAATCGACCGAGCTAACCGCAGCAAAGCGGTAGGTA
CGATCGATCAAGTGGTTACTAGCCTTAAAGAGAGTGATGTTTCAGTATGGATGTTCCCTGAGGGGACTCGTTCTCGTGGT
CGTGGTTTGTTGCCATTCAAAACGGGTGCTTTCCATGCTGCGATTGGCGCTGGCTTACCTATTATCCCTATCGTGTGTAG
CTCAACAGGTGGCGTGAAGCTGAACCGTTGGAACAATGGTCATGTGATTGTTGAAATGCTGCCACCAATCAGCACTGAAG
ATTACGATAAGTCTAATGTTCGTCAACTGGCTAACCTAGCTCGTGAGCAGATGGCAGCGAAGCTTGAAGAGTTAGACAAA
GAAGTGATTGAGCTTAATAAGAAGTAA

Upstream 100 bases:

>100_bases
TGAAAACATAAAAGTCGGAACCTTGGTTTCGGCTTTTTTATAGTTGTATTTACCGCAAGTGAGTCTATTGCCCATTGTTG
TGCGAATAGATGAATGAGCT

Downstream 100 bases:

>100_bases
TCATCTAAGCGAAACGATGAACAATAAAAAAGGTTGCCAATTGGGCAACCTTTTTTGTATCTGATAAACGCTCAGCATTA
TGCCAACTTGTTTACTAGAA

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRLVRNKMIAILRIFAVAIFAILMFVFGCGYCLLSPRNPKHVFTFGRYFGRMSKIFGMKLELRIPEDAYSRGQHVYVANH
QNSWDLFTISSAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANRSKAVGTIDQVVTSLKESDVSVWMFPEGTRSRG
RGLLPFKTGAFHAAIGAGLPIIPIVCSSTGGVKLNRWNNGHVIVEMLPPISTEDYDKSNVRQLANLAREQMAAKLEELDK
EVIELNKK

Sequences:

>Translated_248_residues
MRLVRNKMIAILRIFAVAIFAILMFVFGCGYCLLSPRNPKHVFTFGRYFGRMSKIFGMKLELRIPEDAYSRGQHVYVANH
QNSWDLFTISSAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANRSKAVGTIDQVVTSLKESDVSVWMFPEGTRSRG
RGLLPFKTGAFHAAIGAGLPIIPIVCSSTGGVKLNRWNNGHVIVEMLPPISTEDYDKSNVRQLANLAREQMAAKLEELDK
EVIELNKK
>Mature_248_residues
MRLVRNKMIAILRIFAVAIFAILMFVFGCGYCLLSPRNPKHVFTFGRYFGRMSKIFGMKLELRIPEDAYSRGQHVYVANH
QNSWDLFTISSAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANRSKAVGTIDQVVTSLKESDVSVWMFPEGTRSRG
RGLLPFKTGAFHAAIGAGLPIIPIVCSSTGGVKLNRWNNGHVIVEMLPPISTEDYDKSNVRQLANLAREQMAAKLEELDK
EVIELNKK

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=223, Percent_Identity=32.2869955156951, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI15100175, Length=223, Percent_Identity=32.2869955156951, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI6041665, Length=232, Percent_Identity=27.1551724137931, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789395, Length=238, Percent_Identity=61.3445378151261, Blast_Score=307, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17564032, Length=208, Percent_Identity=31.7307692307692, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17568319, Length=213, Percent_Identity=31.924882629108, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320151, Length=231, Percent_Identity=30.7359307359307, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281364648, Length=242, Percent_Identity=28.5123966942149, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582856, Length=242, Percent_Identity=28.5123966942149, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582854, Length=242, Percent_Identity=28.5123966942149, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641614, Length=220, Percent_Identity=33.6363636363636, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24641612, Length=220, Percent_Identity=33.6363636363636, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27818; Mature: 27818

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVRNKMIAILRIFAVAIFAILMFVFGCGYCLLSPRNPKHVFTFGRYFGRMSKIFGMKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCEE
ELRIPEDAYSRGQHVYVANHQNSWDLFTISSAVTPKVVTVGKKSLAWMPLFGQLYWLTGN
EEECCHHHHHCCCEEEEECCCCCCEEEEECCCCCCEEEEECCCCEEECHHHHEEEEEECE
ILIDRANRSKAVGTIDQVVTSLKESDVSVWMFPEGTRSRGRGLLPFKTGAFHAAIGAGLP
EEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCC
IIPIVCSSTGGVKLNRWNNGHVIVEMLPPISTEDYDKSNVRQLANLAREQMAAKLEELDK
EEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVIELNKK
HHHHCCCC
>Mature Secondary Structure
MRLVRNKMIAILRIFAVAIFAILMFVFGCGYCLLSPRNPKHVFTFGRYFGRMSKIFGMKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCEE
ELRIPEDAYSRGQHVYVANHQNSWDLFTISSAVTPKVVTVGKKSLAWMPLFGQLYWLTGN
EEECCHHHHHCCCEEEEECCCCCCEEEEECCCCCCEEEEECCCCEEECHHHHEEEEEECE
ILIDRANRSKAVGTIDQVVTSLKESDVSVWMFPEGTRSRGRGLLPFKTGAFHAAIGAGLP
EEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCC
IIPIVCSSTGGVKLNRWNNGHVIVEMLPPISTEDYDKSNVRQLANLAREQMAAKLEELDK
EEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EVIELNKK
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]