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The map label for this gene is mutY [H]

Identifier: 218710638

GI number: 218710638

Start: 2878308

End: 2879366

Strand: Direct

Name: mutY [H]

Synonym: VS_2692

Alternate gene names: 218710638

Gene position: 2878308-2879366 (Clockwise)

Preceding gene: 218710635

Following gene: 218710639

Centisome position: 87.24

GC content: 45.8

Gene sequence:

>1059_bases
GTGACTCCTTTCGCAACCGCCATATTAAAGTGGTATGACGCTTACGGGCGTAAAGAATTACCTTGGCAACAAAACAAAAC
CGCCTACTCCGTTTGGCTATCTGAAATCATGCTTCAGCAGACTCAGGTCGCCACAGTGATTCCATACTACCAACGCTTCT
TGGAACGTTTCCCAACGGTTGTCGACCTAGCGAACGCTGAACAAGATGAAGTGCTTCACTTATGGACAGGGCTTGGTTAC
TACGCACGAGCTCGTAACTTGCACAAAGCAGCCAAGATCGTCGCTGAGCAGTATGGTAGTGAATTTCCGCTTTCTATCGA
AGAGATGAACGCGCTACCGGGGATCGGTCGCTCGACTGCAGCTGCAGTGCTGTCTTCGGTTCACAAACTTCCTCATGCGA
TCCTTGATGGCAATGTAAAACGAACGCTTGCGAGAAGCTTTGCCGTTGAAGGTTGGCCAGGACAAAAGAAAGTCGAGAAC
CAGCTTTGGGAACACGCAGAAGCACACACTCCCAATCAAGATGTTGATAAGTACAATCAAGCCATGATGGACATGGGTGC
GATGGTTTGTACTCGTAGCAAGCCCAAATGTACGTTATGCCCGATTGAAAGCATGTGTGAAGCTAAGAAGCTCGATAGAC
AACTCGATTTCCCTGGCAAGAAACCTAAGAAAGAAAAGCCGATAAAAGAAACATGGTTTGTGATTCTGTACCACAACAAT
CAAGTATGGCTCGAACAACGCCCTCAATCTGGTATCTGGGGAGGACTATTCTGTTTCCCTCAAAATGAAAACGCAGAGAT
CGAACATCAGTTAGACCTTCGTTCGATCAAAGACAATGAAACCGATTCGATCAAGACCATGATTGCGTTTCGACATACTT
TCAGCCACTACCACATAGATATCACGCCTGTATTAGTAAAATTAGATAAACAACCAGATTTGATAATGGAAGGGACTAAA
GGTCTCTGGTATAACTTATCAAAACCGGAAGAAATTGGCCTAGCCGCTCCTGTAAAGCAGCTTATTGAGAGCCTACCCTT
TGAACTGAACGACGTTTGA

Upstream 100 bases:

>100_bases
TCTTTCCGTGGATAAATTCCCACACAATTTGTCTGTTTTACATCCAACGTTAAGTGTGGTGCAATTTCGCTTCTAATAAT
AGCAAAGCATAGAGCATGTC

Downstream 100 bases:

>100_bases
ATCAACGAACGCGATAAGAGGAACCACTATGAGCCGCACTGTATTTTGTGCTCGCCTTCAAAAAGATGCTGAAGGCCTAG
ATTTTCAACTTTACCCGGGT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTPFATAILKWYDAYGRKELPWQQNKTAYSVWLSEIMLQQTQVATVIPYYQRFLERFPTVVDLANAEQDEVLHLWTGLGY
YARARNLHKAAKIVAEQYGSEFPLSIEEMNALPGIGRSTAAAVLSSVHKLPHAILDGNVKRTLARSFAVEGWPGQKKVEN
QLWEHAEAHTPNQDVDKYNQAMMDMGAMVCTRSKPKCTLCPIESMCEAKKLDRQLDFPGKKPKKEKPIKETWFVILYHNN
QVWLEQRPQSGIWGGLFCFPQNENAEIEHQLDLRSIKDNETDSIKTMIAFRHTFSHYHIDITPVLVKLDKQPDLIMEGTK
GLWYNLSKPEEIGLAAPVKQLIESLPFELNDV

Sequences:

>Translated_352_residues
MTPFATAILKWYDAYGRKELPWQQNKTAYSVWLSEIMLQQTQVATVIPYYQRFLERFPTVVDLANAEQDEVLHLWTGLGY
YARARNLHKAAKIVAEQYGSEFPLSIEEMNALPGIGRSTAAAVLSSVHKLPHAILDGNVKRTLARSFAVEGWPGQKKVEN
QLWEHAEAHTPNQDVDKYNQAMMDMGAMVCTRSKPKCTLCPIESMCEAKKLDRQLDFPGKKPKKEKPIKETWFVILYHNN
QVWLEQRPQSGIWGGLFCFPQNENAEIEHQLDLRSIKDNETDSIKTMIAFRHTFSHYHIDITPVLVKLDKQPDLIMEGTK
GLWYNLSKPEEIGLAAPVKQLIESLPFELNDV
>Mature_351_residues
TPFATAILKWYDAYGRKELPWQQNKTAYSVWLSEIMLQQTQVATVIPYYQRFLERFPTVVDLANAEQDEVLHLWTGLGYY
ARARNLHKAAKIVAEQYGSEFPLSIEEMNALPGIGRSTAAAVLSSVHKLPHAILDGNVKRTLARSFAVEGWPGQKKVENQ
LWEHAEAHTPNQDVDKYNQAMMDMGAMVCTRSKPKCTLCPIESMCEAKKLDRQLDFPGKKPKKEKPIKETWFVILYHNNQ
VWLEQRPQSGIWGGLFCFPQNENAEIEHQLDLRSIKDNETDSIKTMIAFRHTFSHYHIDITPVLVKLDKQPDLIMEGTKG
LWYNLSKPEEIGLAAPVKQLIESLPFELNDV

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=373, Percent_Identity=31.9034852546917, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI6912520, Length=373, Percent_Identity=31.9034852546917, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI115298654, Length=373, Percent_Identity=31.9034852546917, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI115298652, Length=373, Percent_Identity=31.9034852546917, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI115298650, Length=373, Percent_Identity=31.9034852546917, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI115298648, Length=373, Percent_Identity=31.9034852546917, Blast_Score=188, Evalue=6e-48,
Organism=Escherichia coli, GI1789331, Length=343, Percent_Identity=57.1428571428571, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787920, Length=134, Percent_Identity=32.8358208955224, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40340; Mature: 40209

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFATAILKWYDAYGRKELPWQQNKTAYSVWLSEIMLQQTQVATVIPYYQRFLERFPTV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKIVAEQYGSEFPLSIEEMNALPGIGRSTA
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHH
AAVLSSVHKLPHAILDGNVKRTLARSFAVEGWPGQKKVENQLWEHAEAHTPNQDVDKYNQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
AMMDMGAMVCTRSKPKCTLCPIESMCEAKKLDRQLDFPGKKPKKEKPIKETWFVILYHNN
HHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECC
QVWLEQRPQSGIWGGLFCFPQNENAEIEHQLDLRSIKDNETDSIKTMIAFRHTFSHYHID
EEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEE
ITPVLVKLDKQPDLIMEGTKGLWYNLSKPEEIGLAAPVKQLIESLPFELNDV
EEEEEEEECCCCCEEEECCCCCEEECCCCHHCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TPFATAILKWYDAYGRKELPWQQNKTAYSVWLSEIMLQQTQVATVIPYYQRFLERFPTV
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKIVAEQYGSEFPLSIEEMNALPGIGRSTA
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHH
AAVLSSVHKLPHAILDGNVKRTLARSFAVEGWPGQKKVENQLWEHAEAHTPNQDVDKYNQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
AMMDMGAMVCTRSKPKCTLCPIESMCEAKKLDRQLDFPGKKPKKEKPIKETWFVILYHNN
HHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECC
QVWLEQRPQSGIWGGLFCFPQNENAEIEHQLDLRSIKDNETDSIKTMIAFRHTFSHYHID
EEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEE
ITPVLVKLDKQPDLIMEGTKGLWYNLSKPEEIGLAAPVKQLIESLPFELNDV
EEEEEEEECCCCCEEEECCCCCEEECCCCHHCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]