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The map label for this gene is lpxD [H]

Identifier: 218710539

GI number: 218710539

Start: 2773522

End: 2774562

Strand: Reverse

Name: lpxD [H]

Synonym: VS_2588

Alternate gene names: 218710539

Gene position: 2774562-2773522 (Counterclockwise)

Preceding gene: 218710540

Following gene: 218710538

Centisome position: 84.1

GC content: 41.5

Gene sequence:

>1041_bases
ATGATCAAAGTTTCAGATATCGCCCAAATCGTTGGTGGAAAAATTGAAGGTGATAACACGGTAGAAATATCGAAGATTCG
CCCAGTTTCCAGCGTAGAAGAGGGCGGCTTAGCCATTGTCTTTGCTAAAGCCGATTTAAAAGGGCTATCTGAAACTTTGG
CTGATGTCATTGTTGGGCCAGAAGCCATTTTACAGACTAAAGCAAAAACAAAAATCGTGATTGAGAAGCTCGAAGCTGAG
AAGCTCAATCAACTAATGCGTCATTATAAAGTTCAAAAATATCAATTATTTGATCAAGGGAATACATCAGATACTCCCGA
TGTTTATATCGGAAAGCATTGTCAAATAGGTGAAGGTTGCCATTTCATGCCCGGTGTTAAAATCATGAACGGTGTAACAA
TCGGCAATAACGTTGCAATTCATTCCAATACAGTCATCAAAGAAGGCACAGTGATTGGTAACAATGTCACCATCGACTCT
AACAACTCCATTGGTAATTACAGCTTCGAATACATGACCGGGCACAACACCCGTTATGAACGCGTGGAAAGTGTGGGTCG
AGTGATCATTGGTGATGAAGTTGAAATTGGCTGTAATAACACCATCGACAGAGGCACTTTAGGCGACACCGTTATTGGTC
GTGGAACCAAAATAGATAACCTAGTGCAAATAGGGCATGACTGCAAAATAGGCCAGCATTGTTTACTGGTATCTCAGGCT
GGTTTTGCGGGCCACACTACCTTGGAAGATCATGTCATTGTACATGGTCAAGTCGGTACCGCAGGGCATCTTACTATCGG
GAAAAACTCCGTTATTAAAGCCAAATCAGGTGTGAGCCACTCTTTCCCTGCCAATAGTGATCTGTTCGGTTATCCGGCGA
AAGATGCACGTTCTTATTATAAAAACTTAGCCGTATTGAACAAATTAACTCATCAAAAAAACAGTAACCCCCGTCCAAAC
TCTAAATCGTTAGAACTTGATACAGACAAAAGATCGGTGGTACCGAAAAAGAGCTTAATAGCGAGACTATTTCGTTTATA
G

Upstream 100 bases:

>100_bases
AAAGGCGAAGAGAAAACTGTAGAACAAGAAACAATGTACCTACAAGCGCTTTACCGCTTCTAAGTGGTATTAATCACAAC
TCAAATGACAGAGTAATATT

Downstream 100 bases:

>100_bases
GTTGCCGAACCGAGAGCTTTAAAAATTTAAAGCCCTAACTCGCGATGACTAAGACGGAATAGAACCCTACATATATAAAA
AATAATAAGGAAATGACAAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MIKVSDIAQIVGGKIEGDNTVEISKIRPVSSVEEGGLAIVFAKADLKGLSETLADVIVGPEAILQTKAKTKIVIEKLEAE
KLNQLMRHYKVQKYQLFDQGNTSDTPDVYIGKHCQIGEGCHFMPGVKIMNGVTIGNNVAIHSNTVIKEGTVIGNNVTIDS
NNSIGNYSFEYMTGHNTRYERVESVGRVIIGDEVEIGCNNTIDRGTLGDTVIGRGTKIDNLVQIGHDCKIGQHCLLVSQA
GFAGHTTLEDHVIVHGQVGTAGHLTIGKNSVIKAKSGVSHSFPANSDLFGYPAKDARSYYKNLAVLNKLTHQKNSNPRPN
SKSLELDTDKRSVVPKKSLIARLFRL

Sequences:

>Translated_346_residues
MIKVSDIAQIVGGKIEGDNTVEISKIRPVSSVEEGGLAIVFAKADLKGLSETLADVIVGPEAILQTKAKTKIVIEKLEAE
KLNQLMRHYKVQKYQLFDQGNTSDTPDVYIGKHCQIGEGCHFMPGVKIMNGVTIGNNVAIHSNTVIKEGTVIGNNVTIDS
NNSIGNYSFEYMTGHNTRYERVESVGRVIIGDEVEIGCNNTIDRGTLGDTVIGRGTKIDNLVQIGHDCKIGQHCLLVSQA
GFAGHTTLEDHVIVHGQVGTAGHLTIGKNSVIKAKSGVSHSFPANSDLFGYPAKDARSYYKNLAVLNKLTHQKNSNPRPN
SKSLELDTDKRSVVPKKSLIARLFRL
>Mature_346_residues
MIKVSDIAQIVGGKIEGDNTVEISKIRPVSSVEEGGLAIVFAKADLKGLSETLADVIVGPEAILQTKAKTKIVIEKLEAE
KLNQLMRHYKVQKYQLFDQGNTSDTPDVYIGKHCQIGEGCHFMPGVKIMNGVTIGNNVAIHSNTVIKEGTVIGNNVTIDS
NNSIGNYSFEYMTGHNTRYERVESVGRVIIGDEVEIGCNNTIDRGTLGDTVIGRGTKIDNLVQIGHDCKIGQHCLLVSQA
GFAGHTTLEDHVIVHGQVGTAGHLTIGKNSVIKAKSGVSHSFPANSDLFGYPAKDARSYYKNLAVLNKLTHQKNSNPRPN
SKSLELDTDKRSVVPKKSLIARLFRL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=279, Percent_Identity=26.5232974910394, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1786378, Length=177, Percent_Identity=30.5084745762712, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37526; Mature: 37526

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVSDIAQIVGGKIEGDNTVEISKIRPVSSVEEGGLAIVFAKADLKGLSETLADVIVGP
CCCHHHHHHHHCCEECCCCEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCC
EAILQTKAKTKIVIEKLEAEKLNQLMRHYKVQKYQLFDQGNTSDTPDVYIGKHCQIGEGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCCCCCCC
HFMPGVKIMNGVTIGNNVAIHSNTVIKEGTVIGNNVTIDSNNSIGNYSFEYMTGHNTRYE
CCCCCCEEECCEEECCEEEEECCCEEECCEEECCEEEEECCCCCCCEEEEEEECCCCHHH
RVESVGRVIIGDEVEIGCNNTIDRGTLGDTVIGRGTKIDNLVQIGHDCKIGQHCLLVSQA
HHHHHCCEEECCEEEECCCCCCCCCCCCCCEECCCCCHHHHHHCCCCCCCCCEEEEEECC
GFAGHTTLEDHVIVHGQVGTAGHLTIGKNSVIKAKSGVSHSFPANSDLFGYPAKDARSYY
CCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
KNLAVLNKLTHQKNSNPRPNSKSLELDTDKRSVVPKKSLIARLFRL
HHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MIKVSDIAQIVGGKIEGDNTVEISKIRPVSSVEEGGLAIVFAKADLKGLSETLADVIVGP
CCCHHHHHHHHCCEECCCCEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCC
EAILQTKAKTKIVIEKLEAEKLNQLMRHYKVQKYQLFDQGNTSDTPDVYIGKHCQIGEGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCCCCCCC
HFMPGVKIMNGVTIGNNVAIHSNTVIKEGTVIGNNVTIDSNNSIGNYSFEYMTGHNTRYE
CCCCCCEEECCEEECCEEEEECCCEEECCEEECCEEEEECCCCCCCEEEEEEECCCCHHH
RVESVGRVIIGDEVEIGCNNTIDRGTLGDTVIGRGTKIDNLVQIGHDCKIGQHCLLVSQA
HHHHHCCEEECCEEEECCCCCCCCCCCCCCEECCCCCHHHHHHCCCCCCCCCEEEEEECC
GFAGHTTLEDHVIVHGQVGTAGHLTIGKNSVIKAKSGVSHSFPANSDLFGYPAKDARSYY
CCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
KNLAVLNKLTHQKNSNPRPNSKSLELDTDKRSVVPKKSLIARLFRL
HHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]