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The map label for this gene is ffh [H]

Identifier: 218710520

GI number: 218710520

Start: 2748036

End: 2749448

Strand: Reverse

Name: ffh [H]

Synonym: VS_2559

Alternate gene names: 218710520

Gene position: 2749448-2748036 (Counterclockwise)

Preceding gene: 218710523

Following gene: 218710519

Centisome position: 83.33

GC content: 46.71

Gene sequence:

>1413_bases
TTGAGCGAAGAGAAAACTATGTTTGATAATTTAACGGATCGTCTATCCAAAACGCTGAAAAACATCAGCGGTAAAGGTCG
CCTGACCGAAGACAATATTAAAGAGACGCTGCGTGAAGTACGTATGGCGCTACTTGAAGCCGACGTTGCACTGCCAGTTG
TCCGCGATTTTGTTAAGCGCGTTAAAGAAGGCGCTGTAGGTGTTGAGGTTTCTAAATCTCTCACACCGGGTCAAGAATTC
ATTAAGATCGTTCAAGCTGAACTTGAAGCTGTGATGGGGGAGTCTAACGAGGCTCTTGACCTAGCAGCACAACCGCCAGC
AGTTATCTTAATGGCGGGTCTACAAGGTGCGGGTAAAACCACATCGGTAGGTAAGCTATCTAAGCTCCTGACTGAGCGTG
ATAAGAAGAAAGTTTTGGTTGTGTCTGCCGACGTTTACCGTCCAGCCGCGATCAAACAGCTTGAAACCTTAGCAAGCGAT
GTGGGTGTCGACTTCTTCCCATCTTCAGCTGACCAAAAGCCTCTTGATATTGCAAACGCTGCAATCGACCACGCGAAGAA
GAAATTCTACGACGTGCTAATTGTCGATACTGCCGGTCGTTTGGCTATCGATGAAGAGATGATGGGTGAAATCAAAGAGC
TTCATACTGCCATTAAACCAGTAGAGACGCTGTTCGTTGTTGATGCTATGACAGGTCAAGATGCTGCGAATACTGCAAAA
GCCTTTGGCGATACGCTACCACTAACCGGTGTTATCTTAACGAAAGTGGATGGTGACGCGCGTGGTGGTGCTGCACTGTC
TGTTCGTCACATCACAGGTAAGCCGATTAAATTCTTAGGTGTTGGTGAGAAAACTGACGCACTAGAACCATTCCACCCAG
ATCGTGTTGCTTCTCGCATCCTAGGTATGGGCGACGTACTGTCTCTTATTGAAGATCTACAGAAGAACGTTGATACCGAG
AAAGCAGAGAAACTGGCTAAGAAGTTCAAAGAGAAGAAAGGTTTTGACCTTGAAGACTTCCGCGAGCAGCTTGGTCAGAT
GAAAAATATGGGCGGCATGATGGGCATGATGGATAAGCTTCCAGGCATGTCTCAGCTACCAGACAACGTTAAAGATAAAG
TTGATGACAAGATGTTCAAGCAAATGGAAGCGATCATCAACTCTATGACAATGAAAGAGCGTCAGCGCCCAGACCTAATC
AAAGGCTCACGCAAAAAGCGTATTGCTGCAGGTTCTGGTACGCAAGTACAAGATGTAAACCGTATGCTTAAACAGTTCAC
TCAAATGCAGAAGATGATGAAGAAAATGCAGAAAGGTGGAATGAAAGGCATGATGCGCAACATGCAAGGCATGATGGGCG
GCGGTGGAGGTATGGGCGGAATGGGTGGTGGTTTTAACCCGTTTGGCCGATAA

Upstream 100 bases:

>100_bases
AGTGAATAATGTCTCACATCACATGCGTGGATGATTAACGCTCCACAACGGGTATGACTCTAATCCGCGCTAATGTATAC
TCACAGTAATAGTCGCAGTT

Downstream 100 bases:

>100_bases
TCTACAAATGTAAGCTTTAGCTACGTTACTTTTCATAGTGTTAGCCGTGTCACAGAAAGTGAGCGGTGGCTATGTTGGTG
AAAAAATAGCTAAAGCCCTT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSEEKTMFDNLTDRLSKTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEF
IKIVQAELEAVMGESNEALDLAAQPPAVILMAGLQGAGKTTSVGKLSKLLTERDKKKVLVVSADVYRPAAIKQLETLASD
VGVDFFPSSADQKPLDIANAAIDHAKKKFYDVLIVDTAGRLAIDEEMMGEIKELHTAIKPVETLFVVDAMTGQDAANTAK
AFGDTLPLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQKNVDTE
KAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPDNVKDKVDDKMFKQMEAIINSMTMKERQRPDLI
KGSRKKRIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGGGGMGGMGGGFNPFGR

Sequences:

>Translated_470_residues
MSEEKTMFDNLTDRLSKTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEF
IKIVQAELEAVMGESNEALDLAAQPPAVILMAGLQGAGKTTSVGKLSKLLTERDKKKVLVVSADVYRPAAIKQLETLASD
VGVDFFPSSADQKPLDIANAAIDHAKKKFYDVLIVDTAGRLAIDEEMMGEIKELHTAIKPVETLFVVDAMTGQDAANTAK
AFGDTLPLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQKNVDTE
KAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPDNVKDKVDDKMFKQMEAIINSMTMKERQRPDLI
KGSRKKRIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGGGGMGGMGGGFNPFGR
>Mature_469_residues
SEEKTMFDNLTDRLSKTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEFI
KIVQAELEAVMGESNEALDLAAQPPAVILMAGLQGAGKTTSVGKLSKLLTERDKKKVLVVSADVYRPAAIKQLETLASDV
GVDFFPSSADQKPLDIANAAIDHAKKKFYDVLIVDTAGRLAIDEEMMGEIKELHTAIKPVETLFVVDAMTGQDAANTAKA
FGDTLPLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQKNVDTEK
AEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPDNVKDKVDDKMFKQMEAIINSMTMKERQRPDLIK
GSRKKRIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGGGGMGGMGGGFNPFGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=31.6027088036117, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=33.9130434782609, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=36.5853658536585, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=26.25, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=26.25, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788963, Length=449, Percent_Identity=77.728285077951, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=34.6456692913386, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.372197309417, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI193206261, Length=216, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=443, Percent_Identity=33.8600451467269, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=25, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=30.2222222222222, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51234; Mature: 51102

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEKTMFDNLTDRLSKTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKEGAVGVEVSKSLTPGQEFIKIVQAELEAVMGESNEALDLAAQPPAVILMAGLQGAGKT
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCC
TSVGKLSKLLTERDKKKVLVVSADVYRPAAIKQLETLASDVGVDFFPSSADQKPLDIANA
CHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
AIDHAKKKFYDVLIVDTAGRLAIDEEMMGEIKELHTAIKPVETLFVVDAMTGQDAANTAK
HHHHHHHHHHHEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHH
AFGDTLPLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPDRVASRI
HHCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDVLSLIEDLQKNVDTEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKL
HCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHC
PGMSQLPDNVKDKVDDKMFKQMEAIINSMTMKERQRPDLIKGSRKKRIAAGSGTQVQDVN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEECCCCCHHHHHH
RMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGGGGMGGMGGGFNPFGR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEEKTMFDNLTDRLSKTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKR
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKEGAVGVEVSKSLTPGQEFIKIVQAELEAVMGESNEALDLAAQPPAVILMAGLQGAGKT
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCC
TSVGKLSKLLTERDKKKVLVVSADVYRPAAIKQLETLASDVGVDFFPSSADQKPLDIANA
CHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
AIDHAKKKFYDVLIVDTAGRLAIDEEMMGEIKELHTAIKPVETLFVVDAMTGQDAANTAK
HHHHHHHHHHHEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHH
AFGDTLPLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPDRVASRI
HHCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDVLSLIEDLQKNVDTEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKL
HCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHC
PGMSQLPDNVKDKVDDKMFKQMEAIINSMTMKERQRPDLIKGSRKKRIAAGSGTQVQDVN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEECCCCCHHHHHH
RMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGGGGMGGMGGGFNPFGR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]