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The map label for this gene is nadC [H]

Identifier: 218710507

GI number: 218710507

Start: 2738409

End: 2739299

Strand: Direct

Name: nadC [H]

Synonym: VS_2546

Alternate gene names: 218710507

Gene position: 2738409-2739299 (Clockwise)

Preceding gene: 218710505

Following gene: 218710508

Centisome position: 83.0

GC content: 46.91

Gene sequence:

>891_bases
ATGAAAAACACACATAACAGCCACCAACGCCTTGATTACTTAAAAGAGCAACTGCCGCTAGAGATCACTCGCGCAGTCGC
TGAGACCATCAAAGAAGATCTAGGTGGAACGTTAGATCCAGCGGCTGATATTACGGCAAGTCTAATCCCTGCAGACGCAA
TCAACAGCGCAACCATCATTACCCGTGAGCACGGTGTGTTCTGTGGTAAAGCTTGGGCAGATGAAGTGTTTAAACAATTG
GGCGGTGAAGTCACTATCGAGTGGAACGTAGAAGACGGTGACAAAGTTGAACCAAACCAAACACTTTGTACCCTAACAGG
CCCTGCTCGCGCACTTTTAACCGGTGAGCGTAACGCAATGAACTTTATTCAAACACTATCTGGTTGTGCGACGGCGACAG
CAATCTACGCTGACAAAATCAAACACACAGAATGCCGCCTATTAGACACGCGTAAAACAATTCCAGGCCTTCGCAGCGCA
CTAAAATACGCTGTGGCTTGTGGTGGTGGCTTCAACCACCGTATTGGTGTTTTCGATGCCTACCTAATCAAAGAAAACCA
CATCATCGCTTGTGGTGGGATTAAGAAGGCTATCTCTACTGCAAAAGAGCTGAACCCAGGTAAGCCTGTAGAAGTTGAAA
CAGAAAGCCTAGCAGAGTTAGAGCAAGCAATCAGCGCGGGTGCAGACATCATCATGCTAGACAACTTCACCACAGACATG
ATGCGGGAAGCGGTTAAAATCAACGCAGGTCGTGCAGCACTAGAAAATTCAGGTAACGTGACTTTAGATACGATTGCAGA
GTTCGCAGAAACGGGTGTCGATTACATCTCTGTCGGTGCACTGACTAAGCATCTAAAAGCAATGGACCTTTCAATGCGAT
TCAAAGCTTAA

Upstream 100 bases:

>100_bases
ATTGTGACTTTGCCCATAGAGCAGTCGCGCTAGCCTCTTTAATTTGAAGTTAAGCAAGAGTATCATTCCATTCCCACTCC
CTTTCAAGATTAGATTTGCG

Downstream 100 bases:

>100_bases
TCTCATAGTTCTATCAATTACTTAACTTCTAGGCATGGCAATCAGCCATGCCTTTTTATTGCTTTTATTATCAGTATATC
AACCAGTTAACTAAGCTGAT

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKNTHNSHQRLDYLKEQLPLEITRAVAETIKEDLGGTLDPAADITASLIPADAINSATIITREHGVFCGKAWADEVFKQL
GGEVTIEWNVEDGDKVEPNQTLCTLTGPARALLTGERNAMNFIQTLSGCATATAIYADKIKHTECRLLDTRKTIPGLRSA
LKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIKKAISTAKELNPGKPVEVETESLAELEQAISAGADIIMLDNFTTDM
MREAVKINAGRAALENSGNVTLDTIAEFAETGVDYISVGALTKHLKAMDLSMRFKA

Sequences:

>Translated_296_residues
MKNTHNSHQRLDYLKEQLPLEITRAVAETIKEDLGGTLDPAADITASLIPADAINSATIITREHGVFCGKAWADEVFKQL
GGEVTIEWNVEDGDKVEPNQTLCTLTGPARALLTGERNAMNFIQTLSGCATATAIYADKIKHTECRLLDTRKTIPGLRSA
LKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIKKAISTAKELNPGKPVEVETESLAELEQAISAGADIIMLDNFTTDM
MREAVKINAGRAALENSGNVTLDTIAEFAETGVDYISVGALTKHLKAMDLSMRFKA
>Mature_296_residues
MKNTHNSHQRLDYLKEQLPLEITRAVAETIKEDLGGTLDPAADITASLIPADAINSATIITREHGVFCGKAWADEVFKQL
GGEVTIEWNVEDGDKVEPNQTLCTLTGPARALLTGERNAMNFIQTLSGCATATAIYADKIKHTECRLLDTRKTIPGLRSA
LKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIKKAISTAKELNPGKPVEVETESLAELEQAISAGADIIMLDNFTTDM
MREAVKINAGRAALENSGNVTLDTIAEFAETGVDYISVGALTKHLKAMDLSMRFKA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=284, Percent_Identity=32.7464788732394, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=292, Percent_Identity=60.958904109589, Blast_Score=346, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321162, Length=271, Percent_Identity=32.8413284132841, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31948; Mature: 31948

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTHNSHQRLDYLKEQLPLEITRAVAETIKEDLGGTLDPAADITASLIPADAINSATII
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEE
TREHGVFCGKAWADEVFKQLGGEVTIEWNVEDGDKVEPNQTLCTLTGPARALLTGERNAM
EECCCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCCEEEECCHHHH
NFIQTLSGCATATAIYADKIKHTECRLLDTRKTIPGLRSALKYAVACGGGFNHRIGVFDA
HHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEE
YLIKENHIIACGGIKKAISTAKELNPGKPVEVETESLAELEQAISAGADIIMLDNFTTDM
EEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCCCHHH
MREAVKINAGRAALENSGNVTLDTIAEFAETGVDYISVGALTKHLKAMDLSMRFKA
HHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKNTHNSHQRLDYLKEQLPLEITRAVAETIKEDLGGTLDPAADITASLIPADAINSATII
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEE
TREHGVFCGKAWADEVFKQLGGEVTIEWNVEDGDKVEPNQTLCTLTGPARALLTGERNAM
EECCCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCCEEEECCHHHH
NFIQTLSGCATATAIYADKIKHTECRLLDTRKTIPGLRSALKYAVACGGGFNHRIGVFDA
HHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEE
YLIKENHIIACGGIKKAISTAKELNPGKPVEVETESLAELEQAISAGADIIMLDNFTTDM
EEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCCCHHH
MREAVKINAGRAALENSGNVTLDTIAEFAETGVDYISVGALTKHLKAMDLSMRFKA
HHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]