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The map label for this gene is vmrA [H]

Identifier: 218710438

GI number: 218710438

Start: 2646019

End: 2647356

Strand: Reverse

Name: vmrA [H]

Synonym: VS_2475

Alternate gene names: 218710438

Gene position: 2647356-2646019 (Counterclockwise)

Preceding gene: 218710439

Following gene: 218710434

Centisome position: 80.24

GC content: 47.53

Gene sequence:

>1338_bases
ATGAGTAACTCAATTAGTCGTCAGTTTTGGCGATACACAATCCCTACCGTGGCAGCCATGTTGGTTAATGGCCTGTACCA
AGTGGTGGATGGCATTTTCATTGGCCGCTATGTGGGGGCTGATGGACTTGCAGGTATCAATGTTGCGTGGCCTGTGATTG
GTTCGATTCTCGGTATTGGTATGTTGGTGGGCGTGGGTACCGGTGCACTGGTCTCGATTCGCCAAGGTGAAAAAGATACT
CAAGGCGCTAAGCAGATCTTAGCAACGGGCTTAACCCTGTTGTTAGCGATAACGCCTATTGTCTCCGCATTGCTGTTTTT
GTTTGCTGATAACTTCTTGCTTTGGCAGGGCGCTGAAGGGCGAGTGTATGAACTTGGCTTGCAGTACTTACACATTCTGA
TTGGTGCTAGTGTCTTCACGCTAGGTTCGATCGCGATGCCGTTTCTACTGCGTAACGATGACAGCCCTAATTTAGCGACG
ATATTGATGATCGTTGGTGCTGTGATTAATATCGTACTCGATTACCTGTTTATCGCTCTGTATGGTTGGGAGTTGATGGG
CGCGGCACTAGCAACAGCTATCGCACAATTTGTGGTAACGGGCTTAGGTCTGGTTTACTTCTTTTCACGTCGAGCAAATT
TACGCTTACGTTGGAATGAGTTACGACTGAAGCTATCGGTTATCCCACAGATCTTCGCCATTGGTACATCAAGCTTCTTT
ATGTACGCTTATGGTTCGATGATGGTGGCGCTGCACAATGCGTTGTTCTCCCAATATGGCGACCAGTTGATGATTGGTGC
TTACGCGATTTTGGGCTACATAGTGACGGTTTATTATCTCACGGCTGAAGGTATCGCCAATGGCATGCAACCTTTGGTGA
GCTACAACCATGGTGCGCGTAACCAAGCGAACATTCGTAAGTTACTTAAGATTGCGATGCTGAGTTCGGTATTGATTGGT
GTGGCGTTCGTGCTGCTTCTGAACGCATTCCCACGTGAGTTTGTATCAGTCTTTAACTCGGACGAACCTCAGTTAGTTGA
GTACACAGTATTAGGTATTCGACTACACATGTTTGCATTGGCGCTTGATGGTTTCTTAGTGGTAGCGGGCGCTTATTACC
AAGCGGTAAACAAGGGCAGCAAGGCGATGTTTGTAACGATAGGCAATATGCTGATCCAGTTACCTTTCTTGTACATTATG
CCTAAGTTGTACGGTGTGCCGGGGATCTGGGTTGCGTACCCACTGTCTAATATTGCGCTAAGCGTGGTGGTGATGGTGAT
GCTCTACAAAGATGTAAAGAAGCTCGATGTCTCACCGATGAATACAGCGGCGGCATAG

Upstream 100 bases:

>100_bases
CTTTGAAGTAAATAATTTAGATATTTAGTTAGCCTTGTTAACTAATTTTTCGAGTCATATCTTGTTGATATGCGACTCAC
AGATGAAAGTAGAGTAAGAA

Downstream 100 bases:

>100_bases
GTCGTATTTCTTAAGTAGAATTAAAAAGGTCTAGCGAATGCTAGACCTTTTTGTCTCTGTGGCTGATGGGTTTAACTCTA
GAAACTAGATGTTTTTAACG

Product: multidrug efflux pump VmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSNSISRQFWRYTIPTVAAMLVNGLYQVVDGIFIGRYVGADGLAGINVAWPVIGSILGIGMLVGVGTGALVSIRQGEKDT
QGAKQILATGLTLLLAITPIVSALLFLFADNFLLWQGAEGRVYELGLQYLHILIGASVFTLGSIAMPFLLRNDDSPNLAT
ILMIVGAVINIVLDYLFIALYGWELMGAALATAIAQFVVTGLGLVYFFSRRANLRLRWNELRLKLSVIPQIFAIGTSSFF
MYAYGSMMVALHNALFSQYGDQLMIGAYAILGYIVTVYYLTAEGIANGMQPLVSYNHGARNQANIRKLLKIAMLSSVLIG
VAFVLLLNAFPREFVSVFNSDEPQLVEYTVLGIRLHMFALALDGFLVVAGAYYQAVNKGSKAMFVTIGNMLIQLPFLYIM
PKLYGVPGIWVAYPLSNIALSVVVMVMLYKDVKKLDVSPMNTAAA

Sequences:

>Translated_445_residues
MSNSISRQFWRYTIPTVAAMLVNGLYQVVDGIFIGRYVGADGLAGINVAWPVIGSILGIGMLVGVGTGALVSIRQGEKDT
QGAKQILATGLTLLLAITPIVSALLFLFADNFLLWQGAEGRVYELGLQYLHILIGASVFTLGSIAMPFLLRNDDSPNLAT
ILMIVGAVINIVLDYLFIALYGWELMGAALATAIAQFVVTGLGLVYFFSRRANLRLRWNELRLKLSVIPQIFAIGTSSFF
MYAYGSMMVALHNALFSQYGDQLMIGAYAILGYIVTVYYLTAEGIANGMQPLVSYNHGARNQANIRKLLKIAMLSSVLIG
VAFVLLLNAFPREFVSVFNSDEPQLVEYTVLGIRLHMFALALDGFLVVAGAYYQAVNKGSKAMFVTIGNMLIQLPFLYIM
PKLYGVPGIWVAYPLSNIALSVVVMVMLYKDVKKLDVSPMNTAAA
>Mature_444_residues
SNSISRQFWRYTIPTVAAMLVNGLYQVVDGIFIGRYVGADGLAGINVAWPVIGSILGIGMLVGVGTGALVSIRQGEKDTQ
GAKQILATGLTLLLAITPIVSALLFLFADNFLLWQGAEGRVYELGLQYLHILIGASVFTLGSIAMPFLLRNDDSPNLATI
LMIVGAVINIVLDYLFIALYGWELMGAALATAIAQFVVTGLGLVYFFSRRANLRLRWNELRLKLSVIPQIFAIGTSSFFM
YAYGSMMVALHNALFSQYGDQLMIGAYAILGYIVTVYYLTAEGIANGMQPLVSYNHGARNQANIRKLLKIAMLSSVLIGV
AFVLLLNAFPREFVSVFNSDEPQLVEYTVLGIRLHMFALALDGFLVVAGAYYQAVNKGSKAMFVTIGNMLIQLPFLYIMP
KLYGVPGIWVAYPLSNIALSVVVMVMLYKDVKKLDVSPMNTAAA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48483; Mature: 48352

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSISRQFWRYTIPTVAAMLVNGLYQVVDGIFIGRYVGADGLAGINVAWPVIGSILGIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MLVGVGTGALVSIRQGEKDTQGAKQILATGLTLLLAITPIVSALLFLFADNFLLWQGAEG
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RVYELGLQYLHILIGASVFTLGSIAMPFLLRNDDSPNLATILMIVGAVINIVLDYLFIAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGWELMGAALATAIAQFVVTGLGLVYFFSRRANLRLRWNELRLKLSVIPQIFAIGTSSFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHH
MYAYGSMMVALHNALFSQYGDQLMIGAYAILGYIVTVYYLTAEGIANGMQPLVSYNHGAR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NQANIRKLLKIAMLSSVLIGVAFVLLLNAFPREFVSVFNSDEPQLVEYTVLGIRLHMFAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
ALDGFLVVAGAYYQAVNKGSKAMFVTIGNMLIQLPFLYIMPKLYGVPGIWVAYPLSNIAL
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SVVVMVMLYKDVKKLDVSPMNTAAA
HHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SNSISRQFWRYTIPTVAAMLVNGLYQVVDGIFIGRYVGADGLAGINVAWPVIGSILGIG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MLVGVGTGALVSIRQGEKDTQGAKQILATGLTLLLAITPIVSALLFLFADNFLLWQGAEG
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RVYELGLQYLHILIGASVFTLGSIAMPFLLRNDDSPNLATILMIVGAVINIVLDYLFIAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGWELMGAALATAIAQFVVTGLGLVYFFSRRANLRLRWNELRLKLSVIPQIFAIGTSSFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHH
MYAYGSMMVALHNALFSQYGDQLMIGAYAILGYIVTVYYLTAEGIANGMQPLVSYNHGAR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NQANIRKLLKIAMLSSVLIGVAFVLLLNAFPREFVSVFNSDEPQLVEYTVLGIRLHMFAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
ALDGFLVVAGAYYQAVNKGSKAMFVTIGNMLIQLPFLYIMPKLYGVPGIWVAYPLSNIAL
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SVVVMVMLYKDVKKLDVSPMNTAAA
HHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA