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The map label for this gene is gcvR [H]

Identifier: 218710273

GI number: 218710273

Start: 2475524

End: 2476066

Strand: Direct

Name: gcvR [H]

Synonym: VS_2306

Alternate gene names: 218710273

Gene position: 2475524-2476066 (Clockwise)

Preceding gene: 218710270

Following gene: 218710274

Centisome position: 75.03

GC content: 44.94

Gene sequence:

>543_bases
ATGACTCAACATCTAGTAATCACAGCTGTGGGCACAGATCGCCCAGGTGTATGCAACCAAGTGGTTCATTTAGTCACCCA
ATCAGGCTGTAACATTATTGATAGCCGTATCGCTCAATTTGGCGAAGAATTTACGCTTATCATGCTACTGTCTGGAAAGG
CAAACAACATCACCCGCGTTGAAACCACCCTGCCCTTGCTTGGACAAGAGCACGACTTGATTACGATTATGAAGCGAACC
TCAACTCATGATGTGATTGAGAACTCTTACACAGTAGAGGTGTTCGTTGAGTCAGACGATAAAATCGGCCTTACCGAGCA
GTTTACCCAGTTCTTCGCAGACCGAAACATCGGCCTCGATTCGTTAAGTGCGCGAACCATCAATAAGTCTAAGGTTCAGC
TCGACAACGACCAATTCCATATCTCTATTACCGCTTCTGTGCAATCAGAATGTAATTTGATGCAGCTACAAGAAGAATTC
GACGCGCTGTGTCAGAGCCTATCCGTACAAGGCTCGCTCAACTTTATCAAAAACAGTTTTTAA

Upstream 100 bases:

>100_bases
TTGAAGCAAAGTGCCTCATAAAAGCCCCAAGCACACACTTATTCCTCTAGCTAACTGTGCTAACATGCATTAATCAATGG
AATATAAGAGACGTGATTTT

Downstream 100 bases:

>100_bases
AAAGGAAATATCATGAATACGCTAACGGCTGGTGTTCCAGCACCTGCATTTTCTCTTCCAGATCAAGATGGCAATATCGT
ATCTCTTGGTGACTTCAAAG

Product: glycine cleavage system transcriptional

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTQHLVITAVGTDRPGVCNQVVHLVTQSGCNIIDSRIAQFGEEFTLIMLLSGKANNITRVETTLPLLGQEHDLITIMKRT
STHDVIENSYTVEVFVESDDKIGLTEQFTQFFADRNIGLDSLSARTINKSKVQLDNDQFHISITASVQSECNLMQLQEEF
DALCQSLSVQGSLNFIKNSF

Sequences:

>Translated_180_residues
MTQHLVITAVGTDRPGVCNQVVHLVTQSGCNIIDSRIAQFGEEFTLIMLLSGKANNITRVETTLPLLGQEHDLITIMKRT
STHDVIENSYTVEVFVESDDKIGLTEQFTQFFADRNIGLDSLSARTINKSKVQLDNDQFHISITASVQSECNLMQLQEEF
DALCQSLSVQGSLNFIKNSF
>Mature_179_residues
TQHLVITAVGTDRPGVCNQVVHLVTQSGCNIIDSRIAQFGEEFTLIMLLSGKANNITRVETTLPLLGQEHDLITIMKRTS
THDVIENSYTVEVFVESDDKIGLTEQFTQFFADRNIGLDSLSARTINKSKVQLDNDQFHISITASVQSECNLMQLQEEFD
ALCQSLSVQGSLNFIKNSF

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=177, Percent_Identity=42.3728813559322, Blast_Score=140, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20056; Mature: 19925

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHLVITAVGTDRPGVCNQVVHLVTQSGCNIIDSRIAQFGEEFTLIMLLSGKANNITRV
CCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEE
ETTLPLLGQEHDLITIMKRTSTHDVIENSYTVEVFVESDDKIGLTEQFTQFFADRNIGLD
EEECCCCCCCCCEEEEEECCCCHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCC
SLSARTINKSKVQLDNDQFHISITASVQSECNLMQLQEEFDALCQSLSVQGSLNFIKNSF
CCCCCCCCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
TQHLVITAVGTDRPGVCNQVVHLVTQSGCNIIDSRIAQFGEEFTLIMLLSGKANNITRV
CCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEE
ETTLPLLGQEHDLITIMKRTSTHDVIENSYTVEVFVESDDKIGLTEQFTQFFADRNIGLD
EEECCCCCCCCCEEEEEECCCCHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCC
SLSARTINKSKVQLDNDQFHISITASVQSECNLMQLQEEFDALCQSLSVQGSLNFIKNSF
CCCCCCCCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]