Click here to switch to the map view.

The map label for this gene is rnd [H]

Identifier: 218710187

GI number: 218710187

Start: 2384092

End: 2385285

Strand: Reverse

Name: rnd [H]

Synonym: VS_2219

Alternate gene names: 218710187

Gene position: 2385285-2384092 (Counterclockwise)

Preceding gene: 218710188

Following gene: 218710182

Centisome position: 72.3

GC content: 44.72

Gene sequence:

>1194_bases
ATGGTGTTAGAATGCCGACAGTTAATGTCGGCATTTTTGTATCCGGCGATCAAAGTAAAATCAGTGAGAGTTTTTGTGGA
TTATCAAATCATTACCCAAGTGAAAGACCTTGAGCGAGTTTGCCAACAAGCACGTGAAGCCGATGTTGTTATGCTTGATA
CAGAGTTCGTTCGTACAAGAACCTATTACCCTCAATTAGGCTTAATTCAGTTATTTGATGGTGAAACGCTGTCACTGATT
GATCCTATTGCTCTTGATGAAATGACCCCGTTTGTTGGGTTATTGAAAGACACTTCAGTACTGAAAGTTTTGCACGCGTG
TGGCGAAGATCTAGAAGTGTTCCAGAACGCATTTGGCTGTACGCCAACGCCAATGGTTGATACGCAGATCATGGCAGCCT
TCTTAGGTCATGGTCTTTCAACTGGCTTTGCAGCTCTCGTTTCAGAGTTTGTAGGCGTTGACCTAGATAAGAGTGAATCT
CGCACCGACTGGCTAGCGCGTCCGCTTTCTCAAAAGCAACTCGACTACGCAGCAGCAGACGTTCACTACTTGATGCCAAT
GTACAACAAGCTTCTAGAAAAAGTGATGGAAGCGGGCTGGTGGGAAGCGGCGCAGCAAGAGTCTGATTTACAAGTGGCTA
AGCGCATCCGTAAAGCAAACCCAGATAACGCTTACCTTGATATTAAAGGCGCGTGGCAGCTAAAGCCTCAACAGTTAGCG
ATCTTACGACCTTTAGCAACTTGGCGTCTAAAAGAAGCAATCAAGCGCGATTTAGCGCTGAACTTTGTCTTTAAAGAGCA
AGACTTATGGGCAGTAGCGCGTTTCGCGATGAAAGATCCTAAACATATGGAGCAAGAAGGTTTTGATTACCGCTCTGTAC
GTCGCCATGGCGCTAAAATCAGTTCAATCGTTAAGTTAGCTGAGCATACGCCAGAAGAAGAATACCCAGCGCCAGTAGAA
CGTCTAATGGACTACCCAGGTTACAAACAACTCTTCAAAGTGTTGAAAGATGAAGTGAAAACAGCTTCGCAACACAGTGG
TTTAGCGACTGAATTTTTGGCGTCGAAGAAGCAACTTAACCAAGTGTTAAGCTGGATATGGAAGCACGATCGTAATCCTG
AAAAGCTGCCAGATGTTATGCAAGGTTGGCGTTTAGATGTGGTTGGCGAGAAGCTAAATAAAGCGATCAAATAA

Upstream 100 bases:

>100_bases
TGCTGAGCTTGCTAAACGCGCAAGCGAGTAACGAGCTCATTTACGAGAAGATGATGCACCATAAGCCATAGCAGCGCTTA
ATCTAAGCGAGCGCTGAAAA

Downstream 100 bases:

>100_bases
CCAACGACTGCAATGACATTTCGATGATTCAAAGAAAAGCGACCTAATTAAGGTCGCTTTTTTATTTGGTAAAATTTAGC
TAGCTACTCGGCACTTAAGC

Product: Ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MVLECRQLMSAFLYPAIKVKSVRVFVDYQIITQVKDLERVCQQAREADVVMLDTEFVRTRTYYPQLGLIQLFDGETLSLI
DPIALDEMTPFVGLLKDTSVLKVLHACGEDLEVFQNAFGCTPTPMVDTQIMAAFLGHGLSTGFAALVSEFVGVDLDKSES
RTDWLARPLSQKQLDYAAADVHYLMPMYNKLLEKVMEAGWWEAAQQESDLQVAKRIRKANPDNAYLDIKGAWQLKPQQLA
ILRPLATWRLKEAIKRDLALNFVFKEQDLWAVARFAMKDPKHMEQEGFDYRSVRRHGAKISSIVKLAEHTPEEEYPAPVE
RLMDYPGYKQLFKVLKDEVKTASQHSGLATEFLASKKQLNQVLSWIWKHDRNPEKLPDVMQGWRLDVVGEKLNKAIK

Sequences:

>Translated_397_residues
MVLECRQLMSAFLYPAIKVKSVRVFVDYQIITQVKDLERVCQQAREADVVMLDTEFVRTRTYYPQLGLIQLFDGETLSLI
DPIALDEMTPFVGLLKDTSVLKVLHACGEDLEVFQNAFGCTPTPMVDTQIMAAFLGHGLSTGFAALVSEFVGVDLDKSES
RTDWLARPLSQKQLDYAAADVHYLMPMYNKLLEKVMEAGWWEAAQQESDLQVAKRIRKANPDNAYLDIKGAWQLKPQQLA
ILRPLATWRLKEAIKRDLALNFVFKEQDLWAVARFAMKDPKHMEQEGFDYRSVRRHGAKISSIVKLAEHTPEEEYPAPVE
RLMDYPGYKQLFKVLKDEVKTASQHSGLATEFLASKKQLNQVLSWIWKHDRNPEKLPDVMQGWRLDVVGEKLNKAIK
>Mature_397_residues
MVLECRQLMSAFLYPAIKVKSVRVFVDYQIITQVKDLERVCQQAREADVVMLDTEFVRTRTYYPQLGLIQLFDGETLSLI
DPIALDEMTPFVGLLKDTSVLKVLHACGEDLEVFQNAFGCTPTPMVDTQIMAAFLGHGLSTGFAALVSEFVGVDLDKSES
RTDWLARPLSQKQLDYAAADVHYLMPMYNKLLEKVMEAGWWEAAQQESDLQVAKRIRKANPDNAYLDIKGAWQLKPQQLA
ILRPLATWRLKEAIKRDLALNFVFKEQDLWAVARFAMKDPKHMEQEGFDYRSVRRHGAKISSIVKLAEHTPEEEYPAPVE
RLMDYPGYKQLFKVLKDEVKTASQHSGLATEFLASKKQLNQVLSWIWKHDRNPEKLPDVMQGWRLDVVGEKLNKAIK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=233, Percent_Identity=29.1845493562232, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI50301240, Length=233, Percent_Identity=29.1845493562232, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788105, Length=372, Percent_Identity=46.7741935483871, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531757, Length=256, Percent_Identity=26.171875, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=279, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161078302, Length=253, Percent_Identity=28.0632411067194, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 45464; Mature: 45464

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLECRQLMSAFLYPAIKVKSVRVFVDYQIITQVKDLERVCQQAREADVVMLDTEFVRTR
CCCHHHHHHHHHHCCHHEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
TYYPQLGLIQLFDGETLSLIDPIALDEMTPFVGLLKDTSVLKVLHACGEDLEVFQNAFGC
CCCCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
TPTPMVDTQIMAAFLGHGLSTGFAALVSEFVGVDLDKSESRTDWLARPLSQKQLDYAAAD
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
VHYLMPMYNKLLEKVMEAGWWEAAQQESDLQVAKRIRKANPDNAYLDIKGAWQLKPQQLA
HHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
ILRPLATWRLKEAIKRDLALNFVFKEQDLWAVARFAMKDPKHMEQEGFDYRSVRRHGAKI
HHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCHHH
SSIVKLAEHTPEEEYPAPVERLMDYPGYKQLFKVLKDEVKTASQHSGLATEFLASKKQLN
HHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QVLSWIWKHDRNPEKLPDVMQGWRLDVVGEKLNKAIK
HHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVLECRQLMSAFLYPAIKVKSVRVFVDYQIITQVKDLERVCQQAREADVVMLDTEFVRTR
CCCHHHHHHHHHHCCHHEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
TYYPQLGLIQLFDGETLSLIDPIALDEMTPFVGLLKDTSVLKVLHACGEDLEVFQNAFGC
CCCCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
TPTPMVDTQIMAAFLGHGLSTGFAALVSEFVGVDLDKSESRTDWLARPLSQKQLDYAAAD
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
VHYLMPMYNKLLEKVMEAGWWEAAQQESDLQVAKRIRKANPDNAYLDIKGAWQLKPQQLA
HHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
ILRPLATWRLKEAIKRDLALNFVFKEQDLWAVARFAMKDPKHMEQEGFDYRSVRRHGAKI
HHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCHHH
SSIVKLAEHTPEEEYPAPVERLMDYPGYKQLFKVLKDEVKTASQHSGLATEFLASKKQLN
HHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QVLSWIWKHDRNPEKLPDVMQGWRLDVVGEKLNKAIK
HHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]