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The map label for this gene is clpP [H]

Identifier: 218710174

GI number: 218710174

Start: 2354859

End: 2355485

Strand: Reverse

Name: clpP [H]

Synonym: VS_2205

Alternate gene names: 218710174

Gene position: 2355485-2354859 (Counterclockwise)

Preceding gene: 218710175

Following gene: 218710173

Centisome position: 71.39

GC content: 44.66

Gene sequence:

>627_bases
ATGAGCTACCAAGAAAAAAATACAATGCCATCGATTATGGACGCACTAGTTCCTATGGTGGTTGAACAGACTTCCCGTGG
TGAACGTTCTTACGATATTTATTCTCGTCTATTAAAAGAACGTATCATTTTCTTAACAGGTCAAGTGGAAGACCACATGG
CAAATCTTGTCGTGGCTCAACTGCTTTTCTTGGAATCAGAAAACCCAGACAAAGATATCTATCTTTACATCAACTCACCT
GGCGGTAGCGTAACAGCGGGCATGTCTATCTATGACACAATGCAGTTCATCAAGCCAAACGTGAGCACAGTATGTATGGG
TCAAGCTTGCTCTATGGGTGCATTCTTACTAGCGGGTGGTACTCCGGGTAAGCGTCACGTGCTTCCAAACTCACGTGTAA
TGATTCACCAGCCACTTGGCGGCTTCCAAGGCCAAGCGTCTGATATTCAAATTCACGCGCAAGAGATCCTAACGATCAAG
CAAAAGCTAAACAAACTATTGGCAGAGCACACAGGTCAGCCTCTAGAGGTTGTTGAGCGTGATACAGATCGTGACAATTT
CATGTCTGCTGATCAGGCTGTAGAATACGGTTTGGTGGATTCAGTTCTTAATCACCGCGGTCAATAA

Upstream 100 bases:

>100_bases
TAATATCTGACGTAGAAGGTTGACGTACGGTCAACAATTCTGCTAACAATGGTCCGTATGATTTAATCATTCGGGCCATT
TATTTTAGGGACATAAGAAT

Downstream 100 bases:

>100_bases
TTGCAGGGCAATTGTTTAACGCAAAGTGATTCAAATTGATATACACTCAAACATAGAGAGTAAAGGCTAAGAGGTTAGCG
AATGACAGATAAAAGCAAAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSYQEKNTMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERIIFLTGQVEDHMANLVVAQLLFLESENPDKDIYLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGTPGKRHVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
QKLNKLLAEHTGQPLEVVERDTDRDNFMSADQAVEYGLVDSVLNHRGQ

Sequences:

>Translated_208_residues
MSYQEKNTMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERIIFLTGQVEDHMANLVVAQLLFLESENPDKDIYLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGTPGKRHVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
QKLNKLLAEHTGQPLEVVERDTDRDNFMSADQAVEYGLVDSVLNHRGQ
>Mature_207_residues
SYQEKNTMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERIIFLTGQVEDHMANLVVAQLLFLESENPDKDIYLYINSPG
GSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGTPGKRHVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKQ
KLNKLLAEHTGQPLEVVERDTDRDNFMSADQAVEYGLVDSVLNHRGQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=193, Percent_Identity=59.0673575129534, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1786641, Length=208, Percent_Identity=75.4807692307692, Blast_Score=333, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=53.4031413612565, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=59.4736842105263, Blast_Score=247, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23104; Mature: 22973

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQEKNTMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERIIFLTGQVEDHMANLVVAQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHH
LLFLESENPDKDIYLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCHHCCCEEEEECC
TPGKRHVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKQKLNKLLAEHTGQPLEVVER
CCCCCEECCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
DTDRDNFMSADQAVEYGLVDSVLNHRGQ
CCCCHHHHCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYQEKNTMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERIIFLTGQVEDHMANLVVAQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHH
LLFLESENPDKDIYLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCHHCCCEEEEECC
TPGKRHVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKQKLNKLLAEHTGQPLEVVER
CCCCCEECCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
DTDRDNFMSADQAVEYGLVDSVLNHRGQ
CCCCHHHHCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA