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The map label for this gene is ald2 [H]

Identifier: 218710028

GI number: 218710028

Start: 2197962

End: 2199086

Strand: Direct

Name: ald2 [H]

Synonym: VS_2048

Alternate gene names: 218710028

Gene position: 2197962-2199086 (Clockwise)

Preceding gene: 218710022

Following gene: 218710031

Centisome position: 66.62

GC content: 46.13

Gene sequence:

>1125_bases
ATGATCATTGGCGTACCTAAGGAAATCAAGAACCACGAATACCGCGTTGGTATGACCCCAGCTAGCGTGAGAGAACTAAT
CTCACACGGCCACCAAGTTTTTGTAGAAACCAATGCCGGTAATGGTATCGGTTTTTCAGACGATGATTACATCGCTGTAG
GCGCATCCATTCTTCCTACTGCTGCTGACGTTTTCGCGAAAGCAGAAATGATTGTAAAGGTTAAAGAACCTCAAGCTGTC
GAGCGAGCTATGCTTCGCGAAGGGCAAATATTATTTACCTATTTACACCTTGCACCAGATTTTCCACAAACTGAAGAGCT
GATCAAGAGCAAAGCTGTCTGCGTAGCCTATGAGACTGTAACAGATAATATGGGTCGCTTGCCACTATTAGCACCAATGT
CTGAAGTCGCTGGTCGCATGTCTATTCAAGCAGGTGCACAAACACTAGAGAAATCTAACGGTGGTTGTGGTCTTCTTCTT
GGCGGCGTTCCTGGTGTTGAGCCAGCAAAAGTTGTTGTTGTTGGCGGCGGTGTTGTGGGTGCTAACGCAGCACGTATGGC
TGTTGGCCTTCGCGCAGACGTAACCATTCTTGATCGCAACGTAGATACGCTTCGTCGTCTTGATGAAGAATTCCAAGGTC
GCGCAAAAGTGGTTTATTCTACTGAAGACGCTATTGAGAAGCATGTTCTAGAAGCAGACCTAGTGATTGGTGCCGTACTA
ATCCCAGGCGCAGCCGCTCCTAAACTTGTTACAAAAGATCACATCGCTAAGATGAAGCCAGGTTCAGCGGTTGTTGATGT
TGCAATCGACCAAGGTGGTTGTTTTGAAACTTCACATGCAACGACTCACGCTGATCCAACTTACATCGTTGATGACGTAG
TTCACTACTGTGTTGCTAACATGCCAGGTGCCGTTGCTCGTACTTCTACTTACGCACTAAACAATGCAACACTTCCTTAC
ATTGTTAAGCTAGCGAACAAAGGCTACCGCGAAGCACTTCTATCTGATGAAGGTTTCCTAGAAGGTCTAAACGTAATCCA
CGGTAAAGTGACTTGTAAAGAAGTTGCAGAGAGCTTTGACCTAGAATACGTAGCGCCTGCAGAAGCAATCGCCATGTTTA
ACTAA

Upstream 100 bases:

>100_bases
TCAGTATCAAATTTTACTTAAACATATCTATACTAGATATTAATTCGACAGAATTACCCTACACATAGATAAAACAACCA
AAATAAAATGAGGAGTCAGG

Downstream 100 bases:

>100_bases
TGATGTAATGACTAACTGAACGCAATAACCTTCTCGTTGAAGCGTTCAGTTAACTCAGACACATTAAACAAAAAGCCAGT
ACGACATAATGTCGCGCTGG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MIIGVPKEIKNHEYRVGMTPASVRELISHGHQVFVETNAGNGIGFSDDDYIAVGASILPTAADVFAKAEMIVKVKEPQAV
ERAMLREGQILFTYLHLAPDFPQTEELIKSKAVCVAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGCGLLL
GGVPGVEPAKVVVVGGGVVGANAARMAVGLRADVTILDRNVDTLRRLDEEFQGRAKVVYSTEDAIEKHVLEADLVIGAVL
IPGAAAPKLVTKDHIAKMKPGSAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTYALNNATLPY
IVKLANKGYREALLSDEGFLEGLNVIHGKVTCKEVAESFDLEYVAPAEAIAMFN

Sequences:

>Translated_374_residues
MIIGVPKEIKNHEYRVGMTPASVRELISHGHQVFVETNAGNGIGFSDDDYIAVGASILPTAADVFAKAEMIVKVKEPQAV
ERAMLREGQILFTYLHLAPDFPQTEELIKSKAVCVAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGCGLLL
GGVPGVEPAKVVVVGGGVVGANAARMAVGLRADVTILDRNVDTLRRLDEEFQGRAKVVYSTEDAIEKHVLEADLVIGAVL
IPGAAAPKLVTKDHIAKMKPGSAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTYALNNATLPY
IVKLANKGYREALLSDEGFLEGLNVIHGKVTCKEVAESFDLEYVAPAEAIAMFN
>Mature_374_residues
MIIGVPKEIKNHEYRVGMTPASVRELISHGHQVFVETNAGNGIGFSDDDYIAVGASILPTAADVFAKAEMIVKVKEPQAV
ERAMLREGQILFTYLHLAPDFPQTEELIKSKAVCVAYETVTDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGCGLLL
GGVPGVEPAKVVVVGGGVVGANAARMAVGLRADVTILDRNVDTLRRLDEEFQGRAKVVYSTEDAIEKHVLEADLVIGAVL
IPGAAAPKLVTKDHIAKMKPGSAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVANMPGAVARTSTYALNNATLPY
IVKLANKGYREALLSDEGFLEGLNVIHGKVTCKEVAESFDLEYVAPAEAIAMFN

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=350, Percent_Identity=30.8571428571429, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI122939153, Length=350, Percent_Identity=30.8571428571429, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787887, Length=302, Percent_Identity=30.794701986755, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550456, Length=344, Percent_Identity=28.4883720930233, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39782; Mature: 39782

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGVPKEIKNHEYRVGMTPASVRELISHGHQVFVETNAGNGIGFSDDDYIAVGASILPT
CEECCCHHHCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCHHHHH
AADVFAKAEMIVKVKEPQAVERAMLREGQILFTYLHLAPDFPQTEELIKSKAVCVAYETV
HHHHHHHEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEH
TDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGCGLLLGGVPGVEPAKVVVVGGGVVG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ANAARMAVGLRADVTILDRNVDTLRRLDEEFQGRAKVVYSTEDAIEKHVLEADLVIGAVL
CCHHHHEEECCCCEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHC
IPGAAAPKLVTKDHIAKMKPGSAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVAN
CCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTYALNNATLPYIVKLANKGYREALLSDEGFLEGLNVIHGKVTCKEVAESFD
CCCCHHCCEEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCEEHHHHHHHCC
LEYVAPAEAIAMFN
CEEECCHHHHCCCC
>Mature Secondary Structure
MIIGVPKEIKNHEYRVGMTPASVRELISHGHQVFVETNAGNGIGFSDDDYIAVGASILPT
CEECCCHHHCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCHHHHH
AADVFAKAEMIVKVKEPQAVERAMLREGQILFTYLHLAPDFPQTEELIKSKAVCVAYETV
HHHHHHHEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEEEH
TDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSNGGCGLLLGGVPGVEPAKVVVVGGGVVG
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
ANAARMAVGLRADVTILDRNVDTLRRLDEEFQGRAKVVYSTEDAIEKHVLEADLVIGAVL
CCHHHHEEECCCCEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHC
IPGAAAPKLVTKDHIAKMKPGSAVVDVAIDQGGCFETSHATTHADPTYIVDDVVHYCVAN
CCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTYALNNATLPYIVKLANKGYREALLSDEGFLEGLNVIHGKVTCKEVAESFD
CCCCHHCCEEEEECCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCEEHHHHHHHCC
LEYVAPAEAIAMFN
CEEECCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA