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The map label for this gene is lrp [H]

Identifier: 218710027

GI number: 218710027

Start: 2197311

End: 2197805

Strand: Reverse

Name: lrp [H]

Synonym: VS_2047

Alternate gene names: 218710027

Gene position: 2197805-2197311 (Counterclockwise)

Preceding gene: 218710029

Following gene: 218710026

Centisome position: 66.61

GC content: 42.42

Gene sequence:

>495_bases
ATGGCAGACAATTATAAGAAGCCGTCCAAGGAACTAGATCGTATTGACCGCAACATTCTTAATGAGTTGCAAAAAGACGG
TCGTATCTCAAACGTTGAACTCTCAAAACGAGTAGGACTTTCTCCAACTCCATGTCTTGAGCGTGTTCGTCGTTTAGAGC
GTCAAGGTTACATTACTGGGTACACAGCATTGCTGAACCCACAGTACCTTGATGCTTCACTTTTAGTGTTTGTTGAAATT
ACGTTGAACCGTGGTGCGCCAGATGTGTTCGAACAATTCAACACCGCTGTGCAGAAACTGGATGACATCCAAGAGTGTCA
TTTAGTGTCGGGTGATTTTGACTATCTTCTAAAAACACGTGTATCTGATATGGGTGCTTACCGTAAGCTACTGGGTGATA
CGTTACTTCGTCTACCAGGCGTAAACGACACTCGAACTTACGTTGTAATGGAAGAAGTGAAACAAACCAATCAACTTGTG
ATTAAAACTCGTTAA

Upstream 100 bases:

>100_bases
ATTAATATCTAGTATAGATATGTTTAAGTAAAATTTGATACTGAATATTAAAAAGTTGTAGTATATTTTTTTGCAAGGAA
GTAATAAGGTGGAATAAAAA

Downstream 100 bases:

>100_bases
TCACAATTGGTGAAATGAAAGAAAGCGGACATTTGTTCCGCTTTCTTGCTTTCTGGAATTGGGTTTTTCTGTTTGATATG
GTTAAATCAACAGTAGTTTC

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MADNYKKPSKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGYITGYTALLNPQYLDASLLVFVEI
TLNRGAPDVFEQFNTAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRKLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLV
IKTR

Sequences:

>Translated_164_residues
MADNYKKPSKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGYITGYTALLNPQYLDASLLVFVEI
TLNRGAPDVFEQFNTAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRKLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLV
IKTR
>Mature_163_residues
ADNYKKPSKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGYITGYTALLNPQYLDASLLVFVEIT
LNRGAPDVFEQFNTAVQKLDDIQECHLVSGDFDYLLKTRVSDMGAYRKLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLVI
KTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=90.2439024390244, Blast_Score=305, Evalue=1e-84,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=33.112582781457, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790182, Length=140, Percent_Identity=25.7142857142857, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18821; Mature: 18690

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNYKKPSKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGYITG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEE
YTALLNPQYLDASLLVFVEITLNRGAPDVFEQFNTAVQKLDDIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VSDMGAYRKLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLVIKTR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
ADNYKKPSKELDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGYITG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCEE
YTALLNPQYLDASLLVFVEITLNRGAPDVFEQFNTAVQKLDDIQECHLVSGDFDYLLKTR
HHHHCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VSDMGAYRKLLGDTLLRLPGVNDTRTYVVMEEVKQTNQLVIKTR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]