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The map label for this gene is sapD [H]

Identifier: 218709977

GI number: 218709977

Start: 2143629

End: 2144630

Strand: Direct

Name: sapD [H]

Synonym: VS_1996

Alternate gene names: 218709977

Gene position: 2143629-2144630 (Clockwise)

Preceding gene: 218709976

Following gene: 218709978

Centisome position: 64.97

GC content: 46.11

Gene sequence:

>1002_bases
ATGCCGTTACTTGATATTCGACATCTCACCATCAAGATTGAGACCCCTCAAGGGATGGTTAAAGCAGTAGATCGAATGAG
TATTACCCTCAATGAGGGAGAAATTCGTGGCTTAGTAGGTGAATCAGGTTCTGGTAAGAGCTTGGTTGCAAAAGCGATCG
TTGGTGTTTGCAAAGAAAACTGGAAAGTGTCTGCCGACCGAATGCGCCTTGGCAATATCGACCTGCTACAACTAACGCCC
AAAGAACGACGCCGTGTGATCGCTCGCGATATCGCGATGATCTTCCAAGAACCATCGACATGTCTTGACCCTTCCGAAAA
AGTGGGACGCCAGCTAATAGAGGCGATTCCTTCGCGTTCATTTGAAGGTCGATGGTGGCAACGGTTTAAGTGGCGAAAAA
AGCAAGCAATAGCATTACTGCATAAAGTGGGGATCAAAAATCACTCTCACCTAATGGACAGTTATTCTTATGAGTTGACC
GATGGTGAGTGTCAAAAAGTCATGATCGCCATGGCGATCGCTGCCAAGCCAAAAGTGCTAATCGCCGATGAGCCAACCAA
CGATTTAGACCCGATTACGCAGTCTCAAATATTGCGCTTATTGAGCCGAATGAATCAACTTCATAACACGACAATTCTCC
TCATTGGGCACGATTTAACGACCATCACTCAATGGGCGACACGAATAACCGTGATGTACTGCGGTCAGTCCGTTGAGTCT
GCAGATACGACAAAACTGTTGGATGTACCAAAGCATCCTTACACCGTTGCACTGCTAAAAGCGATGCCCGATTTTAACGA
CTGGATTCCCCATAAAGAAAAACTGCAATCTTTACCAGGGTCAATTCCGCCGCTGCAGCACCTTCCGATTGGTTGTCGAC
TTGGACCACGTTGTCCATACGCGCAAAGACAGTGTGTCGAGATCCCGCATACTAAACGTATAAAGACCCACAAATTTAAC
TGTCATTTCCCTCTGAATATGGAGAAGAAAAAGAAATCATGA

Upstream 100 bases:

>100_bases
GGACAGTAACTCTACCCGGCTTAGCCATTATGTTTACAGTGATCGTGATTAACCTTGTCGGTGAAGGTGTTCGCCAAGCG
CTAAATGCAGGAATCGAATA

Downstream 100 bases:

>100_bases
GTGCATTATTAGAGGTCAGTGATTTATCTAAAGACTTTACGACTCGCTCTGGTCTTTTCCGTAAAAAGATTCATCAGGCA
GTGAAGCCAGTCAGCTTTTC

Product: peptide transport system ATP-binding protein SapD

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MPLLDIRHLTIKIETPQGMVKAVDRMSITLNEGEIRGLVGESGSGKSLVAKAIVGVCKENWKVSADRMRLGNIDLLQLTP
KERRRVIARDIAMIFQEPSTCLDPSEKVGRQLIEAIPSRSFEGRWWQRFKWRKKQAIALLHKVGIKNHSHLMDSYSYELT
DGECQKVMIAMAIAAKPKVLIADEPTNDLDPITQSQILRLLSRMNQLHNTTILLIGHDLTTITQWATRITVMYCGQSVES
ADTTKLLDVPKHPYTVALLKAMPDFNDWIPHKEKLQSLPGSIPPLQHLPIGCRLGPRCPYAQRQCVEIPHTKRIKTHKFN
CHFPLNMEKKKKS

Sequences:

>Translated_333_residues
MPLLDIRHLTIKIETPQGMVKAVDRMSITLNEGEIRGLVGESGSGKSLVAKAIVGVCKENWKVSADRMRLGNIDLLQLTP
KERRRVIARDIAMIFQEPSTCLDPSEKVGRQLIEAIPSRSFEGRWWQRFKWRKKQAIALLHKVGIKNHSHLMDSYSYELT
DGECQKVMIAMAIAAKPKVLIADEPTNDLDPITQSQILRLLSRMNQLHNTTILLIGHDLTTITQWATRITVMYCGQSVES
ADTTKLLDVPKHPYTVALLKAMPDFNDWIPHKEKLQSLPGSIPPLQHLPIGCRLGPRCPYAQRQCVEIPHTKRIKTHKFN
CHFPLNMEKKKKS
>Mature_332_residues
PLLDIRHLTIKIETPQGMVKAVDRMSITLNEGEIRGLVGESGSGKSLVAKAIVGVCKENWKVSADRMRLGNIDLLQLTPK
ERRRVIARDIAMIFQEPSTCLDPSEKVGRQLIEAIPSRSFEGRWWQRFKWRKKQAIALLHKVGIKNHSHLMDSYSYELTD
GECQKVMIAMAIAAKPKVLIADEPTNDLDPITQSQILRLLSRMNQLHNTTILLIGHDLTTITQWATRITVMYCGQSVESA
DTTKLLDVPKHPYTVALLKAMPDFNDWIPHKEKLQSLPGSIPPLQHLPIGCRLGPRCPYAQRQCVEIPHTKRIKTHKFNC
HFPLNMEKKKKS

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4170

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787548, Length=330, Percent_Identity=63.3333333333333, Blast_Score=466, Evalue=1e-133,
Organism=Escherichia coli, GI1789963, Length=328, Percent_Identity=41.7682926829268, Blast_Score=260, Evalue=7e-71,
Organism=Escherichia coli, GI1787759, Length=309, Percent_Identity=37.8640776699029, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI48994883, Length=328, Percent_Identity=34.4512195121951, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1787500, Length=330, Percent_Identity=33.9393939393939, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI145693107, Length=270, Percent_Identity=35.5555555555556, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788506, Length=278, Percent_Identity=35.9712230215827, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1787758, Length=288, Percent_Identity=32.2916666666667, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789962, Length=294, Percent_Identity=30.2721088435374, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789890, Length=251, Percent_Identity=30.6772908366534, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789891, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789032, Length=246, Percent_Identity=28.0487804878049, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI48994997, Length=265, Percent_Identity=28.6792452830189, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787547, Length=270, Percent_Identity=27.037037037037, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786398, Length=268, Percent_Identity=27.9850746268657, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788450, Length=239, Percent_Identity=29.2887029288703, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081791, Length=292, Percent_Identity=25.6849315068493, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789873, Length=221, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786703, Length=228, Percent_Identity=28.5087719298246, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787029, Length=234, Percent_Identity=27.3504273504274, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787089, Length=231, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790544, Length=228, Percent_Identity=29.3859649122807, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788761, Length=258, Percent_Identity=25.1937984496124, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48995001, Length=240, Percent_Identity=32.5, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790162, Length=241, Percent_Identity=24.0663900414938, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786345, Length=228, Percent_Identity=28.5087719298246, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787792, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788225, Length=266, Percent_Identity=25.187969924812, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081834, Length=213, Percent_Identity=28.169014084507, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789672, Length=245, Percent_Identity=26.1224489795918, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790467, Length=255, Percent_Identity=23.921568627451, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787712, Length=266, Percent_Identity=25.5639097744361, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081709, Length=257, Percent_Identity=22.9571984435798, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786253, Length=226, Percent_Identity=26.9911504424779, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788644, Length=129, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082267, Length=249, Percent_Identity=24.4979919678715, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790525, Length=233, Percent_Identity=30.4721030042918, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789593, Length=227, Percent_Identity=27.3127753303965, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786872, Length=216, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789991, Length=218, Percent_Identity=24.3119266055046, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786803, Length=224, Percent_Identity=23.2142857142857, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 37827; Mature: 37696

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLDIRHLTIKIETPQGMVKAVDRMSITLNEGEIRGLVGESGSGKSLVAKAIVGVCKEN
CCCEEEEEEEEEEECCCHHHHHHHHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCC
WKVSADRMRLGNIDLLQLTPKERRRVIARDIAMIFQEPSTCLDPSEKVGRQLIEAIPSRS
CEECHHHEEECCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
FEGRWWQRFKWRKKQAIALLHKVGIKNHSHLMDSYSYELTDGECQKVMIAMAIAAKPKVL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEECCCCHHHHHHHHHHHHCCCEEE
IADEPTNDLDPITQSQILRLLSRMNQLHNTTILLIGHDLTTITQWATRITVMYCGQSVES
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEECCCCCC
ADTTKLLDVPKHPYTVALLKAMPDFNDWIPHKEKLQSLPGSIPPLQHLPIGCRLGPRCPY
CCCCEEEECCCCCHHHHHHHHCCCCHHCCCCHHHHHHCCCCCCCHHCCCCCCCCCCCCCC
AQRQCVEIPHTKRIKTHKFNCHFPLNMEKKKKS
HHHHHHCCCCCCCEEEEEEEEECCCCCHHCCCC
>Mature Secondary Structure 
PLLDIRHLTIKIETPQGMVKAVDRMSITLNEGEIRGLVGESGSGKSLVAKAIVGVCKEN
CCEEEEEEEEEEECCCHHHHHHHHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCC
WKVSADRMRLGNIDLLQLTPKERRRVIARDIAMIFQEPSTCLDPSEKVGRQLIEAIPSRS
CEECHHHEEECCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
FEGRWWQRFKWRKKQAIALLHKVGIKNHSHLMDSYSYELTDGECQKVMIAMAIAAKPKVL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEECCCCHHHHHHHHHHHHCCCEEE
IADEPTNDLDPITQSQILRLLSRMNQLHNTTILLIGHDLTTITQWATRITVMYCGQSVES
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEECCCCCC
ADTTKLLDVPKHPYTVALLKAMPDFNDWIPHKEKLQSLPGSIPPLQHLPIGCRLGPRCPY
CCCCEEEECCCCCHHHHHHHHCCCCHHCCCCHHHHHHCCCCCCCHHCCCCCCCCCCCCCC
AQRQCVEIPHTKRIKTHKFNCHFPLNMEKKKKS
HHHHHHCCCCCCCEEEEEEEEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]