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The map label for this gene is gltT [H]

Identifier: 218709955

GI number: 218709955

Start: 2118744

End: 2120063

Strand: Direct

Name: gltT [H]

Synonym: VS_1974

Alternate gene names: 218709955

Gene position: 2118744-2120063 (Clockwise)

Preceding gene: 218709952

Following gene: 218709956

Centisome position: 64.22

GC content: 45.15

Gene sequence:

>1320_bases
ATGGCACATCGCTCATTGGTGAGTAATTCTGGGATTTTTATATTTAGTAGCACAGAGGTTATGGAAGTGTTAAAAGAAAA
GAGTTTACTAAGCAATATTGGCATTCAAGTCGTTATTGCAATGATCATCGGTACAGCAGTCGGCGCGATGATGGGTGACA
GCGCAACAATGTTCGCTCCACTGGGTGCTATCTTCATCAATTTGATCAAGATGCTGGTGATTCCTCTAGTCGCAGTTGCC
CTAATTTCAGGTGCTGCAGGTCTAGGTAATAGCTCATCGGCTGGTAAAGTCGGTGTAACAACACTGGGTTACTTTGCACT
AACGTCTGCACTTGCTGTGGCACTAGCGCTTGTAATGGGTGAAGTGTTCGAACCCGGTCGTGGTATCGATGTTTCTGGCG
TTGAAGGTATGTTCTCTTCAGAATACGCTGCGAAAGGCGAACTTCCAACGTTCTGGGCAACCATCACTGGCATGATCCCT
ACCAACGTTTTCCAATCACTGAATGAAGCAAACATTCTGCAAATTCTCGTTTTCTGCTTATTCTTTGGTATTGCGATTTC
TAAACAAGCAAAAGAGAAACGTGACCCTATCATCAACGGTGTAAATGCTATCGTTGACGCTATGGTATGGATGATCAACA
AAGTTATGATCATTGCACCACTTGGCGTATTCGGCCTAATGGCTGAAGCAGTAGGTACGTTTGGTTTTGGCGCGCTTATG
GTCGTGTTCAAGCTGTTCATTGTTTACATCGCTGCGATTCTTATCTTCGGCTTTGTTGCTTACCCACTGATGATTCAAAT
CTTCACTAAGACTTCAGCTAAGAAGTTCCTAGTGGCAATGAAGAAGCCTCAAGCGGTTGCACTATCAACAGCATCTTCAA
TGGCGACACTACCAGTAACAATGGAAACGGTAGAGAAAGAACTTGGCGTTCGCAACTCTACGGCTTCATTCGTTCTGCCA
CTTGGTGCGACGATCAACATGTCTGGTAATGCAATTTACTACGGCCTAGTTGCTATCTTCTTCGCACAGCTGTTCAACAT
CGACCTTTCTATGGGCGCTTACGTTGCTATCATCGTAACGTCTACGCTAGGCGCAGTTGGTCAAGCAGGAGTTCCAGGTC
CTTCTTTCCTAGTGGTTGCGGTTCTTCTAGCAGCTGGTATCCCTATCGAAGGTCTACCTCTGTTGTTCGCTCTAGACCGT
ATCTTCGACATGATTCGTACTGCTCTTAACATCACTGGTGATGCAGCATGTGCGGTAATCGTTGATTCTCTAATCAAAGA
CGAAGTGAAAGAAGCTGAGCTAGAGAAACAACAAGCTTAA

Upstream 100 bases:

>100_bases
CTAATAGCGATTCACCTGCTGTTTTTAAGAGACTTTCACCTCTGCTCATATTGATAAATGTAAAGGATACGTGTAAAACT
CTTCGCGAAATATTTATCCA

Downstream 100 bases:

>100_bases
ACTTCTTCGAAACCTAAAGACCAAAAAGCCACTCATTGAGTGGCTTTTTTACTTTCAATGTACCGTCCTAAATATGGTTG
ACACATTTCCAACATGAAAT

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAHRSLVSNSGIFIFSSTEVMEVLKEKSLLSNIGIQVVIAMIIGTAVGAMMGDSATMFAPLGAIFINLIKMLVIPLVAVA
LISGAAGLGNSSSAGKVGVTTLGYFALTSALAVALALVMGEVFEPGRGIDVSGVEGMFSSEYAAKGELPTFWATITGMIP
TNVFQSLNEANILQILVFCLFFGIAISKQAKEKRDPIINGVNAIVDAMVWMINKVMIIAPLGVFGLMAEAVGTFGFGALM
VVFKLFIVYIAAILIFGFVAYPLMIQIFTKTSAKKFLVAMKKPQAVALSTASSMATLPVTMETVEKELGVRNSTASFVLP
LGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYVAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDR
IFDMIRTALNITGDAACAVIVDSLIKDEVKEAELEKQQA

Sequences:

>Translated_439_residues
MAHRSLVSNSGIFIFSSTEVMEVLKEKSLLSNIGIQVVIAMIIGTAVGAMMGDSATMFAPLGAIFINLIKMLVIPLVAVA
LISGAAGLGNSSSAGKVGVTTLGYFALTSALAVALALVMGEVFEPGRGIDVSGVEGMFSSEYAAKGELPTFWATITGMIP
TNVFQSLNEANILQILVFCLFFGIAISKQAKEKRDPIINGVNAIVDAMVWMINKVMIIAPLGVFGLMAEAVGTFGFGALM
VVFKLFIVYIAAILIFGFVAYPLMIQIFTKTSAKKFLVAMKKPQAVALSTASSMATLPVTMETVEKELGVRNSTASFVLP
LGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYVAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDR
IFDMIRTALNITGDAACAVIVDSLIKDEVKEAELEKQQA
>Mature_438_residues
AHRSLVSNSGIFIFSSTEVMEVLKEKSLLSNIGIQVVIAMIIGTAVGAMMGDSATMFAPLGAIFINLIKMLVIPLVAVAL
ISGAAGLGNSSSAGKVGVTTLGYFALTSALAVALALVMGEVFEPGRGIDVSGVEGMFSSEYAAKGELPTFWATITGMIPT
NVFQSLNEANILQILVFCLFFGIAISKQAKEKRDPIINGVNAIVDAMVWMINKVMIIAPLGVFGLMAEAVGTFGFGALMV
VFKLFIVYIAAILIFGFVAYPLMIQIFTKTSAKKFLVAMKKPQAVALSTASSMATLPVTMETVEKELGVRNSTASFVLPL
GATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYVAIIVTSTLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRI
FDMIRTALNITGDAACAVIVDSLIKDEVKEAELEKQQA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=30.5164319248826, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI66773030, Length=472, Percent_Identity=29.2372881355932, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI169790839, Length=460, Percent_Identity=28.0434782608696, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4827012, Length=452, Percent_Identity=27.8761061946903, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI40254478, Length=469, Percent_Identity=28.3582089552239, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI5032093, Length=404, Percent_Identity=31.4356435643564, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI223468566, Length=315, Percent_Identity=32.3809523809524, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI223468564, Length=280, Percent_Identity=33.5714285714286, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI262359914, Length=459, Percent_Identity=25.0544662309368, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI301601644, Length=162, Percent_Identity=39.5061728395062, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI194239697, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=33.4894613583138, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789947, Length=420, Percent_Identity=30, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1788024, Length=411, Percent_Identity=26.5206812652068, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789473, Length=384, Percent_Identity=26.3020833333333, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206505, Length=413, Percent_Identity=30.5084745762712, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI193206654, Length=453, Percent_Identity=29.5805739514349, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17541374, Length=429, Percent_Identity=29.6037296037296, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=27.8396436525612, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17537407, Length=411, Percent_Identity=29.683698296837, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71983106, Length=423, Percent_Identity=29.3144208037825, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=423, Percent_Identity=29.3144208037825, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24583025, Length=407, Percent_Identity=26.5356265356265, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI17137668, Length=407, Percent_Identity=26.5356265356265, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24583023, Length=407, Percent_Identity=26.5356265356265, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI281360483, Length=450, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17137666, Length=450, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281360481, Length=450, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46083; Mature: 45951

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRSLVSNSGIFIFSSTEVMEVLKEKSLLSNIGIQVVIAMIIGTAVGAMMGDSATMFAP
CCCCHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LGAIFINLIKMLVIPLVAVALISGAAGLGNSSSAGKVGVTTLGYFALTSALAVALALVMG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVFEPGRGIDVSGVEGMFSSEYAAKGELPTFWATITGMIPTNVFQSLNEANILQILVFCL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FFGIAISKQAKEKRDPIINGVNAIVDAMVWMINKVMIIAPLGVFGLMAEAVGTFGFGALM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFKLFIVYIAAILIFGFVAYPLMIQIFTKTSAKKFLVAMKKPQAVALSTASSMATLPVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCHH
METVEKELGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYVAIIVT
HHHHHHHHCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
STLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVI
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VDSLIKDEVKEAELEKQQA
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AHRSLVSNSGIFIFSSTEVMEVLKEKSLLSNIGIQVVIAMIIGTAVGAMMGDSATMFAP
CCCHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LGAIFINLIKMLVIPLVAVALISGAAGLGNSSSAGKVGVTTLGYFALTSALAVALALVMG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVFEPGRGIDVSGVEGMFSSEYAAKGELPTFWATITGMIPTNVFQSLNEANILQILVFCL
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FFGIAISKQAKEKRDPIINGVNAIVDAMVWMINKVMIIAPLGVFGLMAEAVGTFGFGALM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFKLFIVYIAAILIFGFVAYPLMIQIFTKTSAKKFLVAMKKPQAVALSTASSMATLPVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCHH
METVEKELGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYVAIIVT
HHHHHHHHCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
STLGAVGQAGVPGPSFLVVAVLLAAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVI
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VDSLIKDEVKEAELEKQQA
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]